Contributions of bioinformatics to study natural antifungals: review in a pharmacological context

Detalhes bibliográficos
Autor(a) principal: Miozza, Valeria
Data de Publicação: 2020
Outros Autores: Barceló, Sebastián, Passero, Pablo, Farah, Ezequiel, Pérez, Cristina
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48160
Resumo: Universidade de Buenos Aires. Faculdade de Odontologia. Farmacologia. Buenos Aires, Argentina.
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spelling Miozza, ValeriaBarceló, SebastiánPassero, PabloFarah, EzequielPérez, Cristina2021-07-12T18:18:11Z2021-07-12T18:18:11Z2020MIOZZA, Valeria et al. Contributions of bioinformatics to study natural antifungals: review in a pharmacological context. Revista Fitos, Rio de Janeiro, v. 14, n. 4, p. 547-562, 2020.1808-9569https://www.arca.fiocruz.br/handle/icict/4816010.17648/2446-4775.2020.944porFundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e SaúdeContributions of bioinformatics to study natural antifungals: review in a pharmacological contextinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de Buenos Aires. Faculdade de Odontologia. Farmacologia. Buenos Aires, Argentina.Universidade de Buenos Aires. Faculdade de Odontologia. Farmacologia. Buenos Aires, Argentina.Universidade de Buenos Aires. Faculdade de Odontologia. Farmacologia. Buenos Aires, Argentina.Universidade de Buenos Aires. Faculdade de Medicina. Farmacologia. Buenos Aires, Argentina.Universidade de Buenos Aires. Faculdade de Odontologia. Farmacologia. Buenos Aires, Argentina.In the last decades, computational techniques have become valuable tools for research of biological systems. They are applied to biochemistry, immunology, pharmacology, etc. Regarding antimicrobial agents, the search for new medicaments or pharmacological strategies is fully justified because of different reasons such as emergence of resistance and drug interactions, particularly in immunocompromised patients. In this work we proposed to update knowledge about application of computational methods to research on natural antifungal compounds. We searched scientific findings through electronic databases according to pertinence and relevance of the information. Then, we analyzed and selected articles in order to organize the information in different items according to set schedules. We updated information about in silico studies regarding new and already known natural antifungal agents. Data were then placed in a pharmacological context regarding molecular targets, mechanisms of therapeutic and toxic effects, as well as resistance mechanisms and their reversion, with special focus on human mycoses. Thus, in this review we summarized important contributions of bioinformatics studies to the design and discovery of new potential agents.  We also integrated data related to pharmacology and other disciplines in order to provide a framework for the bioinformatics findings.BioinformaticsComputational StudiesTheoretical StudiesAntifungal AgentsNatural Productsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/48160/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALvaleria_et_all.pdfapplication/pdf533323https://www.arca.fiocruz.br/bitstream/icict/48160/2/valeria_et_all.pdf29d709f8a99ff1101193d72552cdf3e7MD52TEXTvaleria_et_all.pdf.txtvaleria_et_all.pdf.txtExtracted texttext/plain53152https://www.arca.fiocruz.br/bitstream/icict/48160/3/valeria_et_all.pdf.txt5a6221b02e962eaa54fe12f9fe149c14MD53icict/481602021-07-28 09:36:56.431oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-07-28T12:36:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Contributions of bioinformatics to study natural antifungals: review in a pharmacological context
title Contributions of bioinformatics to study natural antifungals: review in a pharmacological context
spellingShingle Contributions of bioinformatics to study natural antifungals: review in a pharmacological context
Miozza, Valeria
Bioinformatics
Computational Studies
Theoretical Studies
Antifungal Agents
Natural Products
title_short Contributions of bioinformatics to study natural antifungals: review in a pharmacological context
title_full Contributions of bioinformatics to study natural antifungals: review in a pharmacological context
title_fullStr Contributions of bioinformatics to study natural antifungals: review in a pharmacological context
title_full_unstemmed Contributions of bioinformatics to study natural antifungals: review in a pharmacological context
title_sort Contributions of bioinformatics to study natural antifungals: review in a pharmacological context
author Miozza, Valeria
author_facet Miozza, Valeria
Barceló, Sebastián
Passero, Pablo
Farah, Ezequiel
Pérez, Cristina
author_role author
author2 Barceló, Sebastián
Passero, Pablo
Farah, Ezequiel
Pérez, Cristina
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Miozza, Valeria
Barceló, Sebastián
Passero, Pablo
Farah, Ezequiel
Pérez, Cristina
dc.subject.en.pt_BR.fl_str_mv Bioinformatics
Computational Studies
Theoretical Studies
Antifungal Agents
Natural Products
topic Bioinformatics
Computational Studies
Theoretical Studies
Antifungal Agents
Natural Products
description Universidade de Buenos Aires. Faculdade de Odontologia. Farmacologia. Buenos Aires, Argentina.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-07-12T18:18:11Z
dc.date.available.fl_str_mv 2021-07-12T18:18:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv MIOZZA, Valeria et al. Contributions of bioinformatics to study natural antifungals: review in a pharmacological context. Revista Fitos, Rio de Janeiro, v. 14, n. 4, p. 547-562, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48160
dc.identifier.issn.pt_BR.fl_str_mv 1808-9569
dc.identifier.doi.pt_BR.fl_str_mv 10.17648/2446-4775.2020.944
identifier_str_mv MIOZZA, Valeria et al. Contributions of bioinformatics to study natural antifungals: review in a pharmacological context. Revista Fitos, Rio de Janeiro, v. 14, n. 4, p. 547-562, 2020.
1808-9569
10.17648/2446-4775.2020.944
url https://www.arca.fiocruz.br/handle/icict/48160
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e Saúde
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e Saúde
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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