Leishmaniasis treatment: update of possibilities for drug repurposing

Detalhes bibliográficos
Autor(a) principal: Andrade Neto, Valter Viana
Data de Publicação: 2018
Outros Autores: Cunha Junior, Edezio Ferreira, Faioes, Viviane dos Santos, Martins, Thais Pereira, Silva, Raphaela Lopes, Leon, Leonor Laura, Santos, Eduardo Caio Torres
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28846
Resumo: Inclui tabela - Species pathogenic to human, occurrence and clinical manifestation.
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spelling Andrade Neto, Valter VianaCunha Junior, Edezio FerreiraFaioes, Viviane dos SantosMartins, Thais PereiraSilva, Raphaela LopesLeon, Leonor LauraSantos, Eduardo Caio Torres2018-09-18T12:23:40Z2018-09-18T12:23:40Z2018ANDRADE NETO, Valter Viana et al. Leishmaniasis treatment: update of possibilities for drug repurposing. Frontiers in Bioscience, v. 23, p. 967-996, Jan. 2018.1093-9946https://www.arca.fiocruz.br/handle/icict/28846Inclui tabela - Species pathogenic to human, occurrence and clinical manifestation.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.The leishmaniases represent a public health problem in under-developed countries and are considered a neglected disease by the World Health Organization (WHO). They are cuased by Leishmania parasites with different clinical manifestations. Currently, there is no vaccine, and treatment is in-efficient and is associated with both serious side effects often leading to resistance to the parasites. Thus, it is essential to search for new treatment strategies, such as drug repurposing, i.e., the use of drugs that are already used for other diseases. The discovery of new clinical applications for approved drugs is strategic for lowering the cost of drug discovery since human toxicity assays are already conducted. Here, we review a broad analysis of the different aspects of this approach for anti-leishmanial treatment.engFrontiers in BioScienceLeishmanioseReposicionamento de MedicamentosTratamentoRevisãoLeishmaniasisTreatmentDrug RepurposingReviewLeishmaniasis treatment: update of possibilities for drug repurposinginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Leishmaniasis treatment: update of possibilities for drug repurposing
title Leishmaniasis treatment: update of possibilities for drug repurposing
spellingShingle Leishmaniasis treatment: update of possibilities for drug repurposing
Andrade Neto, Valter Viana
Leishmaniose
Reposicionamento de Medicamentos
Tratamento
Revisão
Leishmaniasis
Treatment
Drug Repurposing
Review
title_short Leishmaniasis treatment: update of possibilities for drug repurposing
title_full Leishmaniasis treatment: update of possibilities for drug repurposing
title_fullStr Leishmaniasis treatment: update of possibilities for drug repurposing
title_full_unstemmed Leishmaniasis treatment: update of possibilities for drug repurposing
title_sort Leishmaniasis treatment: update of possibilities for drug repurposing
author Andrade Neto, Valter Viana
author_facet Andrade Neto, Valter Viana
Cunha Junior, Edezio Ferreira
Faioes, Viviane dos Santos
Martins, Thais Pereira
Silva, Raphaela Lopes
Leon, Leonor Laura
Santos, Eduardo Caio Torres
author_role author
author2 Cunha Junior, Edezio Ferreira
Faioes, Viviane dos Santos
Martins, Thais Pereira
Silva, Raphaela Lopes
Leon, Leonor Laura
Santos, Eduardo Caio Torres
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade Neto, Valter Viana
Cunha Junior, Edezio Ferreira
Faioes, Viviane dos Santos
Martins, Thais Pereira
Silva, Raphaela Lopes
Leon, Leonor Laura
Santos, Eduardo Caio Torres
dc.subject.other.pt_BR.fl_str_mv Leishmaniose
Reposicionamento de Medicamentos
Tratamento
Revisão
topic Leishmaniose
Reposicionamento de Medicamentos
Tratamento
Revisão
Leishmaniasis
Treatment
Drug Repurposing
Review
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis
Treatment
Drug Repurposing
Review
description Inclui tabela - Species pathogenic to human, occurrence and clinical manifestation.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-09-18T12:23:40Z
dc.date.available.fl_str_mv 2018-09-18T12:23:40Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE NETO, Valter Viana et al. Leishmaniasis treatment: update of possibilities for drug repurposing. Frontiers in Bioscience, v. 23, p. 967-996, Jan. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28846
dc.identifier.issn.pt_BR.fl_str_mv 1093-9946
identifier_str_mv ANDRADE NETO, Valter Viana et al. Leishmaniasis treatment: update of possibilities for drug repurposing. Frontiers in Bioscience, v. 23, p. 967-996, Jan. 2018.
1093-9946
url https://www.arca.fiocruz.br/handle/icict/28846
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Frontiers in BioScience
publisher.none.fl_str_mv Frontiers in BioScience
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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