Daily oral emtricitabine/tenofovir preexposure prophylaxis and herpes simplex virus type 2 among men who have sex with men
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10377 |
Resumo: | Bill and Melinda Gates Foundation, Gladstone Institutes |
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Marcus, Julia L.Glidden, David V.McMahan, VanessaLama, Javier R.Mayer, Kenneth H.Liu, Albert Y.Herrera, Orlando MontoyaCasapia, MartinHoagland, Brenda Regina de SiqueiraGrant, Robert M.2015-05-15T19:22:06Z2015-05-15T19:22:06Z2014MARCUS, Julia L. et al. Daily oral emtricitabine/tenofovir preexposure prophylaxis and herpes simplex virus type 2 among men who have sex with men. Plos One, v.9, n.3, p.e91513, 2014.1932-6203https://www.arca.fiocruz.br/handle/icict/1037710.1371/journal.pone.00915131932-6203Bill and Melinda Gates Foundation, Gladstone InstitutesGladstone Institute of Virology and Immunology. San Francisco, CA, United States of America / University of California. Berkeley, CA, United States of AmericaUniversity of California San Francisco. San Francisco, CA, United States of AmericaGladstone Institute of Virology and Immunology. San Francisco, CA, United States of AmericaAsociación Civil Impacta Salud y Educación. Lima, PeruFenway Institute. Fenway Health. Boston, MA, United States of America / Beth Israel Deaconess Medical Center. Boston, MA, United States of AmericaBridge HIV. San Francisco Department of Public Health. San Francisco, CA, United States of AmericaFundación Ecuatoriana Equidad. Guayaquil, EcuadorAsociación Civil Selva Amazónica. Iquitos, PeruFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasiGladstone Institute of Virology and Immunology. San Francisco, CA, United States of America / University of California San Francisco. San Francisco, CA, United States of AmericaIn addition to protecting against HIV acquisition, antiretroviral preexposure prophylaxis (PrEP) using topical 1% tenofovir gel reduced Herpes simplex virus type 2 (HSV-2) acquisition by 51% among women in the CAPRISA 004 study. We examined the effect of daily oral emtricitabine/tenofovir (FTC/TDF) PrEP on HSV-2 seroincidence and ulcer occurrence among men who have sex with men (MSM) in the iPrEx trial. Methods HSV-2 serum testing was performed at screening and every six months. Among HSV-2-seronegative individuals, we used Cox regression models to estimate hazard ratios (HRs) of HSV-2 seroincidence associated with randomization to FTC/TDF. We used multiple imputation and Cox regression to estimate HRs for HSV-2 seroincidence accounting for drug exposure. We assessed ulcer occurrence among participants with prevalent or incident HSV-2 infection. Results Of the 2,499 participants, 1383 (55.3%) tested HSV-2-seronegative at baseline, 892 (35.7%) tested positive, 223 (8.9%) had indeterminate tests, and one test was not done. Of the 1,347 HSV-2-seronegative participants with follow-up, 125 (9.3%) had incident HSV-2 infection (5.9 per 100 person-years). Compared with participants receiving placebo, there was no difference in HSV-2 seroincidence among participants receiving FTC/TDF (HR 1.1, 95% CI: 0.8–1.5; P = 0.64) or among participants receiving FTC/TDF with a concentration of tenofovir diphosphate >16 per million viable cells (HR 1.0, 95% CI: 0.3–3.5; P = 0.95). Among participants with HSV-2 infection, the proportion with ≥1 moderate or severe ulcer adverse event was twice as high in the placebo vs. active arm (5.9% vs. 2.9%, P = 0.02), but there were no differences in the proportions with ≥1 clinical examination during which perianal or groin ulcers were identified. Conclusions Tenofovir in daily oral FTC/TDF PrEP may reduce the occurrence of ulcers in individuals with HSV-2 infection but does not protect against HSV-2 incidence among MSM.engPublic Library of ScienceDaily oral emtricitabine/tenofovir preexposure prophylaxis and herpes simplex virus type 2 among men who have sex with meninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHerpesvirus 2, HumanStatistical AnalysisAnti-Retroviral AgentsPre-Exposure ProphylaxisHerpesvirus Humano 2Análise EstatísticaAntirretroviraisProfilaxia Pré-Exposiçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10377/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALDaily oral emtricitabine tenofovir preexposure prophylaxis and herpes simplex virus type 2 among men who have sex with men.pdfDaily 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| dc.title.pt_BR.fl_str_mv |
Daily oral emtricitabine/tenofovir preexposure prophylaxis and herpes simplex virus type 2 among men who have sex with men |
| title |
Daily oral emtricitabine/tenofovir preexposure prophylaxis and herpes simplex virus type 2 among men who have sex with men |
| spellingShingle |
Daily oral emtricitabine/tenofovir preexposure prophylaxis and herpes simplex virus type 2 among men who have sex with men Marcus, Julia L. Herpesvirus 2, Human Statistical Analysis Anti-Retroviral Agents Pre-Exposure Prophylaxis Herpesvirus Humano 2 Análise Estatística Antirretrovirais Profilaxia Pré-Exposição |
| title_short |
Daily oral emtricitabine/tenofovir preexposure prophylaxis and herpes simplex virus type 2 among men who have sex with men |
| title_full |
Daily oral emtricitabine/tenofovir preexposure prophylaxis and herpes simplex virus type 2 among men who have sex with men |
| title_fullStr |
Daily oral emtricitabine/tenofovir preexposure prophylaxis and herpes simplex virus type 2 among men who have sex with men |
| title_full_unstemmed |
Daily oral emtricitabine/tenofovir preexposure prophylaxis and herpes simplex virus type 2 among men who have sex with men |
| title_sort |
Daily oral emtricitabine/tenofovir preexposure prophylaxis and herpes simplex virus type 2 among men who have sex with men |
| author |
Marcus, Julia L. |
| author_facet |
Marcus, Julia L. Glidden, David V. McMahan, Vanessa Lama, Javier R. Mayer, Kenneth H. Liu, Albert Y. Herrera, Orlando Montoya Casapia, Martin Hoagland, Brenda Regina de Siqueira Grant, Robert M. |
| author_role |
author |
| author2 |
Glidden, David V. McMahan, Vanessa Lama, Javier R. Mayer, Kenneth H. Liu, Albert Y. Herrera, Orlando Montoya Casapia, Martin Hoagland, Brenda Regina de Siqueira Grant, Robert M. |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Marcus, Julia L. Glidden, David V. McMahan, Vanessa Lama, Javier R. Mayer, Kenneth H. Liu, Albert Y. Herrera, Orlando Montoya Casapia, Martin Hoagland, Brenda Regina de Siqueira Grant, Robert M. |
| dc.subject.en.pt_BR.fl_str_mv |
Herpesvirus 2, Human Statistical Analysis Anti-Retroviral Agents Pre-Exposure Prophylaxis |
| topic |
Herpesvirus 2, Human Statistical Analysis Anti-Retroviral Agents Pre-Exposure Prophylaxis Herpesvirus Humano 2 Análise Estatística Antirretrovirais Profilaxia Pré-Exposição |
| dc.subject.decs.pt_BR.fl_str_mv |
Herpesvirus Humano 2 Análise Estatística Antirretrovirais Profilaxia Pré-Exposição |
| description |
Bill and Melinda Gates Foundation, Gladstone Institutes |
| publishDate |
2014 |
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2014 |
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2015-05-15T19:22:06Z |
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2015-05-15T19:22:06Z |
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MARCUS, Julia L. et al. Daily oral emtricitabine/tenofovir preexposure prophylaxis and herpes simplex virus type 2 among men who have sex with men. Plos One, v.9, n.3, p.e91513, 2014. |
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https://www.arca.fiocruz.br/handle/icict/10377 |
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1932-6203 |
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10.1371/journal.pone.0091513 |
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1932-6203 |
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MARCUS, Julia L. et al. Daily oral emtricitabine/tenofovir preexposure prophylaxis and herpes simplex virus type 2 among men who have sex with men. Plos One, v.9, n.3, p.e91513, 2014. 1932-6203 10.1371/journal.pone.0091513 |
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