Enhancement of Leishmania amazonensis infection in BCG non-responder mice by BCG-antigen specific vaccine

Detalhes bibliográficos
Autor(a) principal: Calabrese, Kátia da Silva
Data de Publicação: 1992
Outros Autores: Costa, Sylvio Celso Gonçalves da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/s0074-02761992000500010
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36746
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Imunomodulação. Rio de Janeiro, RJ, Brasil.
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spelling Calabrese, Kátia da SilvaCosta, Sylvio Celso Gonçalves da2019-10-29T14:45:55Z2019-10-29T14:45:55Z1992CALABRESE, Kátia da Silva; COSTA, Sylvio Celso Gonçalves da. Enhancement of Leishmania amazonensis infection in BCG non-responder mice by BCG-antigen specific vaccine. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. 1, p. 49-56, 1992.0074-0276https://www.arca.fiocruz.br/handle/icict/3674610.1590/s0074-027619920005000101678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzLeishmania amazonensisFração microssômicaRatos consanguíneosVacinaçãoBCGLeishmania amazonensisInbred miceVaccinationBCGMicrosomal fractionEnhancement of Leishmania amazonensis infection in BCG non-responder mice by BCG-antigen specific vaccineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Imunomodulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Imunomodulação. Rio de Janeiro, RJ, Brasil.Different patterns of cutaneous leishmaniasis can be induced when a challenge of alike dose of Leishmania amazonensis amastigotes in various inbred strains was applied. Two strains of mice, the Balb/c and C57BL/10J, showed exceptional susceptibility, and 10(6) amastigotes infective dose lead, to ulcerative progressive lesions with cutaneous metastasis and loss by necrosis of leg on which the footpad primary lesion occurred. Lesions were also progressive but in a lower degree when C3H/HeN and C57BL/6 were infected. Lesions progress slowly in DBA/2 mice presenting lesions which reach a discreet peak after 12 weeks, do not heal but do not ulcerate. DBA/2 mice is, therefore, a good model for immunomodulation. In attempt to determine the influence of BCG in vaccination schedule using microsomal fraction, DBA/2 became an excellent model, since it is also a non-responder to BCG. Vaccination of DBA/2 mice, receiving the same 10(6) BCG viable dose and 10 micrograms or 50 micrograms of protein content of microsomal fraction, lead to a progressive disease with time course similar to those observed in susceptible non-vaccinated C57BL/10J mice after 6 months of observation. An enhancement of infection in BCG non-responder mice suggests that use of BCG as immunostimulant in humans could be critical for both vaccination and immunoprophylactic strategies.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36746/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALKatiaCalanrese_SylcioCGCosta_IOC_1992.pdfKatiaCalanrese_SylcioCGCosta_IOC_1992.pdfapplication/pdf402053https://www.arca.fiocruz.br/bitstream/icict/36746/2/KatiaCalanrese_SylcioCGCosta_IOC_1992.pdfdc09c319a499ec227350c743fc67f645MD52TEXTKatiaCalanrese_SylcioCGCosta_IOC_1992.pdf.txtKatiaCalanrese_SylcioCGCosta_IOC_1992.pdf.txtExtracted texttext/plain8https://www.arca.fiocruz.br/bitstream/icict/36746/3/KatiaCalanrese_SylcioCGCosta_IOC_1992.pdf.txt8d1b69dd9bdc9df4a8073c7a8193c7afMD53icict/367462022-06-24 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dc.title.pt_BR.fl_str_mv Enhancement of Leishmania amazonensis infection in BCG non-responder mice by BCG-antigen specific vaccine
title Enhancement of Leishmania amazonensis infection in BCG non-responder mice by BCG-antigen specific vaccine
spellingShingle Enhancement of Leishmania amazonensis infection in BCG non-responder mice by BCG-antigen specific vaccine
Calabrese, Kátia da Silva
Leishmania amazonensis
Fração microssômica
Ratos consanguíneos
Vacinação
BCG
Leishmania amazonensis
Inbred mice
Vaccination
BCG
Microsomal fraction
title_short Enhancement of Leishmania amazonensis infection in BCG non-responder mice by BCG-antigen specific vaccine
title_full Enhancement of Leishmania amazonensis infection in BCG non-responder mice by BCG-antigen specific vaccine
title_fullStr Enhancement of Leishmania amazonensis infection in BCG non-responder mice by BCG-antigen specific vaccine
title_full_unstemmed Enhancement of Leishmania amazonensis infection in BCG non-responder mice by BCG-antigen specific vaccine
title_sort Enhancement of Leishmania amazonensis infection in BCG non-responder mice by BCG-antigen specific vaccine
author Calabrese, Kátia da Silva
author_facet Calabrese, Kátia da Silva
Costa, Sylvio Celso Gonçalves da
author_role author
author2 Costa, Sylvio Celso Gonçalves da
author2_role author
dc.contributor.author.fl_str_mv Calabrese, Kátia da Silva
Costa, Sylvio Celso Gonçalves da
dc.subject.other.pt_BR.fl_str_mv Leishmania amazonensis
Fração microssômica
Ratos consanguíneos
Vacinação
BCG
topic Leishmania amazonensis
Fração microssômica
Ratos consanguíneos
Vacinação
BCG
Leishmania amazonensis
Inbred mice
Vaccination
BCG
Microsomal fraction
dc.subject.en.pt_BR.fl_str_mv Leishmania amazonensis
Inbred mice
Vaccination
BCG
Microsomal fraction
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Imunomodulação. Rio de Janeiro, RJ, Brasil.
publishDate 1992
dc.date.issued.fl_str_mv 1992
dc.date.accessioned.fl_str_mv 2019-10-29T14:45:55Z
dc.date.available.fl_str_mv 2019-10-29T14:45:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CALABRESE, Kátia da Silva; COSTA, Sylvio Celso Gonçalves da. Enhancement of Leishmania amazonensis infection in BCG non-responder mice by BCG-antigen specific vaccine. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. 1, p. 49-56, 1992.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36746
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/s0074-02761992000500010
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv CALABRESE, Kátia da Silva; COSTA, Sylvio Celso Gonçalves da. Enhancement of Leishmania amazonensis infection in BCG non-responder mice by BCG-antigen specific vaccine. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. 1, p. 49-56, 1992.
0074-0276
10.1590/s0074-02761992000500010
1678-8060
url https://www.arca.fiocruz.br/handle/icict/36746
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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