Diagnosis of histoplasmosis

Detalhes bibliográficos
Autor(a) principal: Guimarães, Allan Jefferson
Data de Publicação: 2006
Outros Autores: Nosanchuk, Joshua D., Zancopé-Oliveira, Rosely Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/S1517-83822006000100001
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57115
Resumo: Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Departamento de Micro-Imuno-Parasitologia. Serviço de Micologia. Rio de Janeiro, RJ, Brasil / Yeshiva University. Albert Einstein College of Medicine. Department of Medicine (Division of Infectious Diseases) & Microbiology and Imunology. Bronx, New York, USA.
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spelling Guimarães, Allan JeffersonNosanchuk, Joshua D.Zancopé-Oliveira, Rosely Maria2023-02-25T00:19:00Z2023-02-25T00:19:00Z2006GUIMARÃES, Allan Jefferson; NOSANCHUK, Joshua D.; ZANCOPÉ-OLIVEIRA, Rosely Maria. Diagnosis of histoplasmosis. Brazilian Journal of Microbiology, v. 37, n. 1, p. 1-13, 2006.1517-8382https://www.arca.fiocruz.br/handle/icict/5711510.1590/S1517-838220060001000011678-4405engSociedade Brasileira de MicrobiologiaDiagnosis of histoplasmosisDiagnóstico laboratorial da histoplasmoseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Departamento de Micro-Imuno-Parasitologia. Serviço de Micologia. Rio de Janeiro, RJ, Brasil / Yeshiva University. Albert Einstein College of Medicine. Department of Medicine (Division of Infectious Diseases) & Microbiology and Imunology. Bronx, New York, USA.Yeshiva University. Albert Einstein College of Medicine. Department of Medicine (Division of Infectious Diseases) & Microbiology and Imunology. Bronx, New York, USA.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Departamento de Micro-Imuno-Parasitologia. Serviço de Micologia. Rio de Janeiro, RJ, Brasil.Endemic mycoses can be challenging to diagnose and accurate interpretation of laboratory data is important to ensure the most appropriate treatment for the patients. Although the definitive diagnosis of histoplasmosis (HP), one of the most frequent endemic mycoses in the world, is achieved by direct diagnosis performed by micro and/or macroscopic observation of Histoplasma capsulatum (H. capsulatum), serologic evidence of this fungal infection is important since the isolation of the etiologic agents is time-consuming and insensitive. A variety of immunoassays have been used to detect specific antibodies to H. capsulatum. The most applied technique for antibody detection is immunodiffusion with sensitivity between 70 to 100 % and specificity of 100%, depending on the clinical form. The complement fixation (CF) test, a methodology extensively used on the past, is less specific (60 to 90%). Detecting fungal antigens by immunoassays is valuable in immunocompromised individuals where such assays achieve positive predictive values of 96-98%. Most current tests in diagnostic laboratories still utilize unpurified antigenic complexes from either whole fungal cells or their culture filtrates. Emphasis has shifted, however, to clinical immunoassays using highly purified and well-characterized antigens including recombinant antigens. In this paper, we review the current conventional diagnostic tools, such as complement fixation and immunodiffusion, outline the development of novel diagnostic reagents and methods, and discuss their relative merits and disadvantages to the immunodiagnostic of this mycosis.Diagnostic testsCulture based methodsMolecular methodsSerologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Guimarães_Allan_etal_INI_2006.pdfve_Guimarães_Allan_etal_INI_2006.pdfapplication/pdf3218137https://www.arca.fiocruz.br/bitstream/icict/57115/2/ve_Guimar%c3%a3es_Allan_etal_INI_2006.pdf241c3d5e1126a7eb8b8861f6839be65bMD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/57115/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/571152023-02-24 21:20:47.365oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-02-25T00:20:47Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Diagnosis of histoplasmosis
dc.title.alternative.en_US.fl_str_mv Diagnóstico laboratorial da histoplasmose
title Diagnosis of histoplasmosis
spellingShingle Diagnosis of histoplasmosis
Guimarães, Allan Jefferson
Diagnostic tests
Culture based methods
Molecular methods
Serology
title_short Diagnosis of histoplasmosis
title_full Diagnosis of histoplasmosis
title_fullStr Diagnosis of histoplasmosis
title_full_unstemmed Diagnosis of histoplasmosis
title_sort Diagnosis of histoplasmosis
author Guimarães, Allan Jefferson
author_facet Guimarães, Allan Jefferson
Nosanchuk, Joshua D.
Zancopé-Oliveira, Rosely Maria
author_role author
author2 Nosanchuk, Joshua D.
Zancopé-Oliveira, Rosely Maria
author2_role author
author
dc.contributor.author.fl_str_mv Guimarães, Allan Jefferson
Nosanchuk, Joshua D.
Zancopé-Oliveira, Rosely Maria
dc.subject.en.en_US.fl_str_mv Diagnostic tests
Culture based methods
Molecular methods
Serology
topic Diagnostic tests
Culture based methods
Molecular methods
Serology
description Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Departamento de Micro-Imuno-Parasitologia. Serviço de Micologia. Rio de Janeiro, RJ, Brasil / Yeshiva University. Albert Einstein College of Medicine. Department of Medicine (Division of Infectious Diseases) & Microbiology and Imunology. Bronx, New York, USA.
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2023-02-25T00:19:00Z
dc.date.available.fl_str_mv 2023-02-25T00:19:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GUIMARÃES, Allan Jefferson; NOSANCHUK, Joshua D.; ZANCOPÉ-OLIVEIRA, Rosely Maria. Diagnosis of histoplasmosis. Brazilian Journal of Microbiology, v. 37, n. 1, p. 1-13, 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57115
dc.identifier.issn.en_US.fl_str_mv 1517-8382
dc.identifier.doi.none.fl_str_mv 10.1590/S1517-83822006000100001
dc.identifier.eissn.none.fl_str_mv 1678-4405
identifier_str_mv GUIMARÃES, Allan Jefferson; NOSANCHUK, Joshua D.; ZANCOPÉ-OLIVEIRA, Rosely Maria. Diagnosis of histoplasmosis. Brazilian Journal of Microbiology, v. 37, n. 1, p. 1-13, 2006.
1517-8382
10.1590/S1517-83822006000100001
1678-4405
url https://www.arca.fiocruz.br/handle/icict/57115
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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