C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings

Tenforde, Mark W.; Gupte, Nikhil; Dowdy, David W.; Asmuth, David M.; Balagopal, Ashwin; Pollard, Richard B.; Sugandhavesa, Patcharaphan; Lama, Javier R.; Pillay, Sandy; Cardoso, Sandra W.; Pawar, Jyoti; Santos, Breno; Riviere, Cynthia; Mwelase, Noluthando; Kanyama, Cecilia; Kumwenda, Johnstone; Hakim, James G.; Kumarasamy, Nagalingeswaran; Bollinger, Robert; Semba, Richard D.; Campbell, Thomas B.; Gupta, Amita; ACTG PEARLS; NWCS 319 Study Group

C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings

Detalhes bibliográficos
Autor(a) principal:	Tenforde, Mark W.
Data de Publicação:	2015
Outros Autores:	Gupte, Nikhil, Dowdy, David W., Asmuth, David M., Balagopal, Ashwin, Pollard, Richard B., Sugandhavesa, Patcharaphan, Lama, Javier R., Pillay, Sandy, Cardoso, Sandra W., Pawar, Jyoti, Santos, Breno, Riviere, Cynthia, Mwelase, Noluthando, Kanyama, Cecilia, Kumwenda, Johnstone, Hakim, James G., Kumarasamy, Nagalingeswaran, Bollinger, Robert, Semba, Richard D., Campbell, Thomas B., Gupta, Amita, ACTG PEARLS, NWCS 319 Study Group
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/29551
Resumo:	Johns Hopkins University School of Medicine. Baltimore, Maryland, United States of America.

Metadados do item

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spelling	Tenforde, Mark W.Gupte, NikhilDowdy, David W.Asmuth, David M.Balagopal, AshwinPollard, Richard B.Sugandhavesa, PatcharaphanLama, Javier R.Pillay, SandyCardoso, Sandra W.Pawar, JyotiSantos, BrenoRiviere, CynthiaMwelase, NoluthandoKanyama, CeciliaKumwenda, JohnstoneHakim, James G.Kumarasamy, NagalingeswaranBollinger, RobertSemba, Richard D.Campbell, Thomas B.Gupta, AmitaACTG PEARLSNWCS 319 Study Group2018-10-11T18:58:30Z2018-10-11T18:58:30Z2015TENFORDE, Mark W. et al. C-Reactive Protein (CRP), Interferon Gamma-Inducible Protein 10 (IP-10), and Lipopolysaccharide (LPS) Are Associated with Risk of Tuberculosis after Initiation of Antiretroviral Therapy in Resource-Limited Settings. PLoS ONE, v. 10, n. 2, p. 1-16, 2015.1932-6203https://www.arca.fiocruz.br/handle/icict/2955110.1371/journal.pone.0117424engC-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settingsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJohns Hopkins University School of Medicine. Baltimore, Maryland, United States of America.Johns Hopkins University School of Medicine. Baltimore, Maryland, United States of America.Johns Hopkins University Bloomberg School of Public Health. Baltimore, Maryland, United States of America.University of California Davis Medical Center. Sacramento, California, United States of America.Johns Hopkins University School of Medicine. Baltimore, Maryland, United States of America.University of California Davis Medical Center. Sacramento, California, United States of America.Chiang Mai University. Research Institute for Health Sciences. Chiang Mai, Thailand.Asociación Civil Impacta Salud y Educación (IMPACTA) Peru Clinical Trials Unit. Lima, Peru.University of KwaZulu-Natal. Nelson Mandela School of Medicine. Durban, South Africa.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.National AIDS Research Institute. Pune, India.Hospital Nossa Senhora da Conceição. Porto Alegre, RS, Brasil.Les Centres Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunites (GHESKIO). Port-Au-Prince, Haiti.University of Witwatersrand. Johannesburg, South Africa.University of North Carolina Project. Kamuzu Central Hospital. Lilongwe, Malawi.Malawi College of Medicine-Johns Hopkins University Research Project. Blantyre, Malawi.University of Zimbabwe. Harare, Zimbabwe.Y.R. Gaitonde Centre for AIDS Research and Education (YRG CARE). Chennai, India.Johns Hopkins University School of Medicine. Baltimore, Maryland, United States of America.Johns Hopkins University School of Medicine. Baltimore, Maryland, United States of America.University of Colorado Denver School of Medicine. Aurora, Colorado, United States of America.Johns Hopkins University School of Medicine. Baltimore, Maryland, United States of America./ Johns Hopkins University Bloomberg School of Public Health. Baltimore, Maryland, United States of America.Objective: The association between pre-antiretroviral (ART) inflammation and immune activation and risk for incident tuberculosis (TB) after ART initiation among adults is uncertain. Design: Nested case-control study (n = 332) within ACTG PEARLS trial of three ART regimens among 1571 HIV-infected, treatment-naïve adults in 9 countries. We compared cases (participants with incident TB diagnosed by 96 weeks) to a random sample of controls (participants who did not develop TB, stratified by country and treatment arm). Methods We measured pre-ART C-reactive protein (CRP), EndoCab IgM, ferritin, interferon gamma (IFN-γ), interleukin 6 (IL-6), interferon gamma-inducible protein 10 (IP-10), lipopolysaccharide (LPS), soluble CD14 (sCD14), tumor necrosis factor alpha (TNF-α), and CD4/DR+/38+ and CD8/DR+/38+ T cells. Markers were defined according to established cutoff definitions when available, 75th percentile of measured values when not, and detectable versus undetectable for LPS. Using logistic regression, we measured associations between biomarkers and incident TB, adjusting for age, sex, study site, treatment arm, baseline CD4 and log10 viral load. We assessed the discriminatory value of biomarkers using receiver operating characteristic (ROC) analysis. Results: Seventy-seven persons (4.9%) developed incident TB during follow-up. Elevated baseline CRP (aOR 3.25, 95% CI: 1.55–6.81) and IP-10 (aOR 1.89, 95% CI: 1.05–3.39), detectable plasma LPS (aOR 2.39, 95% CI: 1.13–5.06), and the established TB risk factors anemia and hypoalbuminemia were independently associated with incident TB. In ROC analysis, CRP, albumin, and LPS improved discrimination only modestly for TB risk when added to baseline routine patient characteristics including CD4 count, body mass index, and prior TB. Conclusion: Incident TB occurs commonly after ART initiation. Although associated with higher postART TB risk, baseline CRP, IP-10, and LPS add limited value to routine patient characteristics in discriminating who develops active TB. Besides determining ideal cutoffs for these biomarkers, additional biomarkers should be sought that predict TB disease in ART initiators.C-Reactive Protein (CRP)TuberculosisInterferon GammaInducible Protein 10 (IP-10)Lipopolysaccharide (LPS)Antiretroviral Therapyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/29551/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALC-reactive protein (CRP), interferon gamma-inducible protein_Sandra_Cardoso_etal_INI_Lapclin-AIDS_2015.pdfC-reactive protein (CRP), interferon gamma-inducible 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dc.title.pt_BR.fl_str_mv	C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings
title	C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings
spellingShingle	C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings Tenforde, Mark W. C-Reactive Protein (CRP) Tuberculosis Interferon GammaInducible Protein 10 (IP-10) Lipopolysaccharide (LPS) Antiretroviral Therapy
title_short	C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings
title_full	C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings
title_fullStr	C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings
title_full_unstemmed	C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings
title_sort	C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings
author	Tenforde, Mark W.
author_facet	Tenforde, Mark W. Gupte, Nikhil Dowdy, David W. Asmuth, David M. Balagopal, Ashwin Pollard, Richard B. Sugandhavesa, Patcharaphan Lama, Javier R. Pillay, Sandy Cardoso, Sandra W. Pawar, Jyoti Santos, Breno Riviere, Cynthia Mwelase, Noluthando Kanyama, Cecilia Kumwenda, Johnstone Hakim, James G. Kumarasamy, Nagalingeswaran Bollinger, Robert Semba, Richard D. Campbell, Thomas B. Gupta, Amita ACTG PEARLS NWCS 319 Study Group
author_role	author
author2	Gupte, Nikhil Dowdy, David W. Asmuth, David M. Balagopal, Ashwin Pollard, Richard B. Sugandhavesa, Patcharaphan Lama, Javier R. Pillay, Sandy Cardoso, Sandra W. Pawar, Jyoti Santos, Breno Riviere, Cynthia Mwelase, Noluthando Kanyama, Cecilia Kumwenda, Johnstone Hakim, James G. Kumarasamy, Nagalingeswaran Bollinger, Robert Semba, Richard D. Campbell, Thomas B. Gupta, Amita ACTG PEARLS NWCS 319 Study Group
author2_role	author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Tenforde, Mark W. Gupte, Nikhil Dowdy, David W. Asmuth, David M. Balagopal, Ashwin Pollard, Richard B. Sugandhavesa, Patcharaphan Lama, Javier R. Pillay, Sandy Cardoso, Sandra W. Pawar, Jyoti Santos, Breno Riviere, Cynthia Mwelase, Noluthando Kanyama, Cecilia Kumwenda, Johnstone Hakim, James G. Kumarasamy, Nagalingeswaran Bollinger, Robert Semba, Richard D. Campbell, Thomas B. Gupta, Amita ACTG PEARLS NWCS 319 Study Group
dc.subject.en.pt_BR.fl_str_mv	C-Reactive Protein (CRP) Tuberculosis Interferon GammaInducible Protein 10 (IP-10) Lipopolysaccharide (LPS) Antiretroviral Therapy
topic	C-Reactive Protein (CRP) Tuberculosis Interferon GammaInducible Protein 10 (IP-10) Lipopolysaccharide (LPS) Antiretroviral Therapy
description	Johns Hopkins University School of Medicine. Baltimore, Maryland, United States of America.
publishDate	2015
dc.date.issued.fl_str_mv	2015
dc.date.accessioned.fl_str_mv	2018-10-11T18:58:30Z
dc.date.available.fl_str_mv	2018-10-11T18:58:30Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	TENFORDE, Mark W. et al. C-Reactive Protein (CRP), Interferon Gamma-Inducible Protein 10 (IP-10), and Lipopolysaccharide (LPS) Are Associated with Risk of Tuberculosis after Initiation of Antiretroviral Therapy in Resource-Limited Settings. PLoS ONE, v. 10, n. 2, p. 1-16, 2015.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/29551
dc.identifier.issn.pt_BR.fl_str_mv	1932-6203
dc.identifier.doi.none.fl_str_mv	10.1371/journal.pone.0117424
identifier_str_mv	TENFORDE, Mark W. et al. C-Reactive Protein (CRP), Interferon Gamma-Inducible Protein 10 (IP-10), and Lipopolysaccharide (LPS) Are Associated with Risk of Tuberculosis after Initiation of Antiretroviral Therapy in Resource-Limited Settings. PLoS ONE, v. 10, n. 2, p. 1-16, 2015. 1932-6203 10.1371/journal.pone.0117424
url	https://www.arca.fiocruz.br/handle/icict/29551
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings

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