Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol

Detalhes bibliográficos
Autor(a) principal: Rocha, Marcele Neves
Data de Publicação: 2013
Outros Autores: Nogueira, Paula Monalisa, Demicheli, Cynthia, Oliveira, Ludmila Gonçalvez de, Silva, Meiriane Mariano da, Frézard, Frédéric, Melo, Maria Norma, Soares, Rodrigo Pedro Pinto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30401
Resumo: 2020-01-01
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spelling Rocha, Marcele NevesNogueira, Paula MonalisaDemicheli, CynthiaOliveira, Ludmila Gonçalvez deSilva, Meiriane Mariano daFrézard, FrédéricMelo, Maria NormaSoares, Rodrigo Pedro Pinto2018-12-05T16:07:20Z2018-12-05T16:07:20Z2013ROCHA, Marcele Neves et al. Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol. Bioinorganic Chemistry and Applications, v. 2013, p. 1-7, 2013.1565-3633https://www.arca.fiocruz.br/handle/icict/3040110.1155/2013/961783engHindawi Publishing Corporationleishmaniose cutâneaLeishmania amazonensisCutaneous leishmaniasisLeishmania amazonensisCytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapacholinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-01Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Biofísica. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.Leishmania amazonensis is the etiologic agent of the cutaneous and diffuse leishmaniasis often associated with drug resistance. Lapachol [2-hydroxy-3-(3′-methyl-2-butenyl)-1,4-naphthoquinone] displays a wide range of antimicrobial properties against many pathogens. In this study, using the classic microscopic in vitro model, we have analyzed the effects of a series of lapachol and chlorides complexes with antimony (V), bismuth (V), and tin (IV) against L. amazonensis. All seven compounds exhibited antileishmanial activity, but most of the antimony (V) and bismuth (V) complexes were toxic against human HepG2 cells and murine macrophages. The best IC50 values (0.17 0.03 and 0.10 0.11 g/mL) were observed for Tin (IV) complexes (3) [(Lp)(Ph3Sn)] and (6) (Ph3SnCl2), respectively. Their selective indexes (SIs) were 70.65 and 120.35 for HepG2 cells, respectively. However, while analyzing murine macrophages, the SI decreased. Those compounds were moderately toxic for HepG2 cells and toxic for murine macrophages, still underlying the need of chemical modification in this class of compounds.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/30401/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALCytotoxicity and In Vitro Antileishmanial Activity of Antimony.pdfCytotoxicity and In Vitro Antileishmanial Activity of Antimony.pdfapplication/pdf800319https://www.arca.fiocruz.br/bitstream/icict/30401/2/Cytotoxicity%20and%20In%20Vitro%20Antileishmanial%20Activity%20of%20Antimony.pdf963f00dbb2b33bc6c354fb135c6f1b09MD52TEXTCytotoxicity and In Vitro Antileishmanial Activity of Antimony.pdf.txtCytotoxicity and In Vitro Antileishmanial Activity of Antimony.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol
title Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol
spellingShingle Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol
Rocha, Marcele Neves
leishmaniose cutânea
Leishmania amazonensis
Cutaneous leishmaniasis
Leishmania amazonensis
title_short Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol
title_full Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol
title_fullStr Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol
title_full_unstemmed Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol
title_sort Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol
author Rocha, Marcele Neves
author_facet Rocha, Marcele Neves
Nogueira, Paula Monalisa
Demicheli, Cynthia
Oliveira, Ludmila Gonçalvez de
Silva, Meiriane Mariano da
Frézard, Frédéric
Melo, Maria Norma
Soares, Rodrigo Pedro Pinto
author_role author
author2 Nogueira, Paula Monalisa
Demicheli, Cynthia
Oliveira, Ludmila Gonçalvez de
Silva, Meiriane Mariano da
Frézard, Frédéric
Melo, Maria Norma
Soares, Rodrigo Pedro Pinto
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rocha, Marcele Neves
Nogueira, Paula Monalisa
Demicheli, Cynthia
Oliveira, Ludmila Gonçalvez de
Silva, Meiriane Mariano da
Frézard, Frédéric
Melo, Maria Norma
Soares, Rodrigo Pedro Pinto
dc.subject.other.pt_BR.fl_str_mv leishmaniose cutânea
Leishmania amazonensis
topic leishmaniose cutânea
Leishmania amazonensis
Cutaneous leishmaniasis
Leishmania amazonensis
dc.subject.en.pt_BR.fl_str_mv Cutaneous leishmaniasis
Leishmania amazonensis
description 2020-01-01
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2018-12-05T16:07:20Z
dc.date.available.fl_str_mv 2018-12-05T16:07:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ROCHA, Marcele Neves et al. Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol. Bioinorganic Chemistry and Applications, v. 2013, p. 1-7, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30401
dc.identifier.issn.pt_BR.fl_str_mv 1565-3633
dc.identifier.doi.none.fl_str_mv 10.1155/2013/961783
identifier_str_mv ROCHA, Marcele Neves et al. Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol. Bioinorganic Chemistry and Applications, v. 2013, p. 1-7, 2013.
1565-3633
10.1155/2013/961783
url https://www.arca.fiocruz.br/handle/icict/30401
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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