Kinetics of antigen specific and non-specific polyclonal B-cell responses during lethal Plasmodium yoelii malaria
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1992 |
| Outros Autores: | , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/43478 |
Resumo: | Groupe Hospitalier Pitié-Salpétriere. INSERM U 313. Paris, France. |
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Rolland, LaurenceBallet, Jean JacquesDaniel-Ribeiro, Claudio Tadeu2020-09-19T17:34:53Z2020-09-19T17:34:53Z1992ROLLAND, Laurence; BALLET, Jean Jacques; DANIEL-RIBEIRO, Claudio Tadeu. Kinetics of antigen specific and non-specific polyclonal B-cell responses during lethal Plasmodium yoelii malaria. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, n. 2, p. 197-204, Apr./June 1992.0074-0276https://www.arca.fiocruz.br/handle/icict/4347810.1590/S0074-027619920002000051678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.MaláriaPlasmodium yoeliiAntígenosAtivação de células B policlonaisCélulas formadoras de placasMalariaPlasmodium yoeliiPolyclonal B-cell activationPlaque forming cellsAntigenKinetics of antigen specific and non-specific polyclonal B-cell responses during lethal Plasmodium yoelii malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGroupe Hospitalier Pitié-Salpétriere. INSERM U 313. Paris, France.Hôpital St-louis. Paris, France,Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.In order to study the kinetics and composition of the polyclonal B-cell activation associated to malaria infection, antigen-specific and non-specific B-cell responses were evaluated in the spleens of mice infected with Plasmodium yoelii 17 XL or injected with lysed erythrocytes or plasma from P. yoelii infected mice or with P. falciparum culture supernatants. Spleen/body weigth ratio, numbers of nucleated spleen cells and Immunoglobulin-containing and Immunoglobulin-secreting cells increased progressively during the course of infection,in parallel to the parasitemia. A different pattern of kinetics was observed when anti-sheep red blood cell and anti-trinitrophenylated-sheep red blood cell plaque forming cells response were studied: maximum values were observed at early stages of infection, whereas the number of total Immunoglobulin-containing and Immunoglobulin-secreting cells were not yet altered. Conversely, at the end of infection, when these latter values reached their maximum, the anti-sheep red blood cell and anti-trinitrophenylated-sheep red blood cell specific responses were normal or even infranormal. In mice injected with Plasmodium-derived material, a higher increase in antigen-specific PFC was observed, as compared to the increase of Immunoglobulin-containing and Immunoglobulin-secreting cell numbers. This suggested a "preferential" (antigen-plus mitogen-induced) stimulation of antigen-specific cells rather than a generalized non-specific (mitogen-induced) triggering of B-lymphocytes. On the basis of these and previous results, it is suggested that polyclonal B-cell activation that takes place during the course of infection appears as a result of successive waves of antigen-specific B-cell activation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43478/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALClaudioTadeu_DRibeiro_etal_IOC_1992.pdfClaudioTadeu_DRibeiro_etal_IOC_1992.pdfapplication/pdf409704https://www.arca.fiocruz.br/bitstream/icict/43478/2/ClaudioTadeu_DRibeiro_etal_IOC_1992.pdf247fdb7ede120b75482291d3c9dc1be0MD52TEXTClaudioTadeu_DRibeiro_etal_IOC_1992.pdf.txtClaudioTadeu_DRibeiro_etal_IOC_1992.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Kinetics of antigen specific and non-specific polyclonal B-cell responses during lethal Plasmodium yoelii malaria |
| title |
Kinetics of antigen specific and non-specific polyclonal B-cell responses during lethal Plasmodium yoelii malaria |
| spellingShingle |
Kinetics of antigen specific and non-specific polyclonal B-cell responses during lethal Plasmodium yoelii malaria Rolland, Laurence Malária Plasmodium yoelii Antígenos Ativação de células B policlonais Células formadoras de placas Malaria Plasmodium yoelii Polyclonal B-cell activation Plaque forming cells Antigen |
| title_short |
Kinetics of antigen specific and non-specific polyclonal B-cell responses during lethal Plasmodium yoelii malaria |
| title_full |
Kinetics of antigen specific and non-specific polyclonal B-cell responses during lethal Plasmodium yoelii malaria |
| title_fullStr |
Kinetics of antigen specific and non-specific polyclonal B-cell responses during lethal Plasmodium yoelii malaria |
| title_full_unstemmed |
Kinetics of antigen specific and non-specific polyclonal B-cell responses during lethal Plasmodium yoelii malaria |
| title_sort |
Kinetics of antigen specific and non-specific polyclonal B-cell responses during lethal Plasmodium yoelii malaria |
| author |
Rolland, Laurence |
| author_facet |
Rolland, Laurence Ballet, Jean Jacques Daniel-Ribeiro, Claudio Tadeu |
| author_role |
author |
| author2 |
Ballet, Jean Jacques Daniel-Ribeiro, Claudio Tadeu |
| author2_role |
author author |
| dc.contributor.author.fl_str_mv |
Rolland, Laurence Ballet, Jean Jacques Daniel-Ribeiro, Claudio Tadeu |
| dc.subject.other.pt_BR.fl_str_mv |
Malária Plasmodium yoelii Antígenos Ativação de células B policlonais Células formadoras de placas |
| topic |
Malária Plasmodium yoelii Antígenos Ativação de células B policlonais Células formadoras de placas Malaria Plasmodium yoelii Polyclonal B-cell activation Plaque forming cells Antigen |
| dc.subject.en.pt_BR.fl_str_mv |
Malaria Plasmodium yoelii Polyclonal B-cell activation Plaque forming cells Antigen |
| description |
Groupe Hospitalier Pitié-Salpétriere. INSERM U 313. Paris, France. |
| publishDate |
1992 |
| dc.date.issued.fl_str_mv |
1992 |
| dc.date.accessioned.fl_str_mv |
2020-09-19T17:34:53Z |
| dc.date.available.fl_str_mv |
2020-09-19T17:34:53Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
ROLLAND, Laurence; BALLET, Jean Jacques; DANIEL-RIBEIRO, Claudio Tadeu. Kinetics of antigen specific and non-specific polyclonal B-cell responses during lethal Plasmodium yoelii malaria. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, n. 2, p. 197-204, Apr./June 1992. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/43478 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S0074-02761992000200005 |
| dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
| identifier_str_mv |
ROLLAND, Laurence; BALLET, Jean Jacques; DANIEL-RIBEIRO, Claudio Tadeu. Kinetics of antigen specific and non-specific polyclonal B-cell responses during lethal Plasmodium yoelii malaria. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, n. 2, p. 197-204, Apr./June 1992. 0074-0276 10.1590/S0074-02761992000200005 1678-8060 |
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https://www.arca.fiocruz.br/handle/icict/43478 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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