Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters

Bibliographic Details
Main Author: Silva, Diana Rodrigues da
Publication Date: 2012
Other Authors: Castro, Solange Lisboa de, Alves, Monique Castro da Silva, Batista, Wanderson da Silva, Oliveira, Gabriel Melo de
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/15699
Summary: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
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spelling Silva, Diana Rodrigues daCastro, Solange Lisboa deAlves, Monique Castro da SilvaBatista, Wanderson da SilvaOliveira, Gabriel Melo de2016-09-06T15:08:20Z2016-09-06T15:08:20Z2012SILVA, Diana Rodrigues da; et al. Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters. Mem Inst Oswaldo Cruz, v.107, n.2, p.211-216, Mar. 2012.0074-0276https://www.arca.fiocruz.br/handle/icict/1569910.1590/S0074-027620120002000101678-8060engFundação Oswaldo CruzTrypanosoma cruziDoença de ChagasSinais clínicosParâmetros não-invasivosTrypanosoma cruziChagas DiseaseClinical signsnon-invasive parametersMurine modelAcute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parametersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Trypanosoma cruzi infection has a large public health impact in Latin American countries. Although the transmission rates via blood transfusions and insect vectors have declined sharply in the past 20 years due to policies of the Southern Cone countries, a large number of people are still at risk for infection. Currently, no accepted experimental model or descriptions of the clinical signs that occur during the course of acute murine infection are available. The aim of this work was to use non-invasive methods to evaluate the clinical signs of Balb/c mice infected with the Y strain of T. cruzi. The infected mice displayed evident clinical changes beginning in the third week of infection. The mice were evaluated based on physical characteristics, spontaneous activity, exploratory behaviour and physiological alterations. We hope that the results presented in this report provide parameters that complement the effective monitoring of trypanocidal treatment and other interventions used to treat experimental Chagas disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15699/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALdiana_silva_etal_IOC_2012.pdfdiana_silva_etal_IOC_2012.pdfapplication/pdf652986https://www.arca.fiocruz.br/bitstream/icict/15699/2/diana_silva_etal_IOC_2012.pdf466e8b86353d091c6dc8e998c990faf5MD52TEXTdiana_silva_etal_IOC_2012.pdf.txtdiana_silva_etal_IOC_2012.pdf.txtExtracted texttext/plain31671https://www.arca.fiocruz.br/bitstream/icict/15699/3/diana_silva_etal_IOC_2012.pdf.txt642093ad18caf95505b57354e63fc24aMD53icict/156992018-04-02 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dc.title.pt_BR.fl_str_mv Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters
title Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters
spellingShingle Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters
Silva, Diana Rodrigues da
Trypanosoma cruzi
Doença de Chagas
Sinais clínicos
Parâmetros não-invasivos
Trypanosoma cruzi
Chagas Disease
Clinical signs
non-invasive parameters
Murine model
title_short Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters
title_full Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters
title_fullStr Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters
title_full_unstemmed Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters
title_sort Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters
author Silva, Diana Rodrigues da
author_facet Silva, Diana Rodrigues da
Castro, Solange Lisboa de
Alves, Monique Castro da Silva
Batista, Wanderson da Silva
Oliveira, Gabriel Melo de
author_role author
author2 Castro, Solange Lisboa de
Alves, Monique Castro da Silva
Batista, Wanderson da Silva
Oliveira, Gabriel Melo de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva, Diana Rodrigues da
Castro, Solange Lisboa de
Alves, Monique Castro da Silva
Batista, Wanderson da Silva
Oliveira, Gabriel Melo de
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Doença de Chagas
Sinais clínicos
Parâmetros não-invasivos
topic Trypanosoma cruzi
Doença de Chagas
Sinais clínicos
Parâmetros não-invasivos
Trypanosoma cruzi
Chagas Disease
Clinical signs
non-invasive parameters
Murine model
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Chagas Disease
Clinical signs
non-invasive parameters
Murine model
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2016-09-06T15:08:20Z
dc.date.available.fl_str_mv 2016-09-06T15:08:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Diana Rodrigues da; et al. Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters. Mem Inst Oswaldo Cruz, v.107, n.2, p.211-216, Mar. 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15699
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762012000200010
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv SILVA, Diana Rodrigues da; et al. Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters. Mem Inst Oswaldo Cruz, v.107, n.2, p.211-216, Mar. 2012.
0074-0276
10.1590/S0074-02762012000200010
1678-8060
url https://www.arca.fiocruz.br/handle/icict/15699
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/15699/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/15699/2/diana_silva_etal_IOC_2012.pdf
https://www.arca.fiocruz.br/bitstream/icict/15699/3/diana_silva_etal_IOC_2012.pdf.txt
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bitstream.checksumAlgorithm.fl_str_mv MD5
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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