Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke

Detalhes bibliográficos
Autor(a) principal: Bourhy, Lena
Data de Publicação: 2022
Outros Autores: Mazeraud, Aurélien, Bozza, Fernando A., Turc, Guillaume, Lledo, Pierre-Marie, Sharshar, Tarek
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/53553
Resumo: Institut Pasteur. Université de Paris. Centre National de Recherche Scientifique. Unité Mixte de Recherche (CNRS UMR) 3571. Perception and Memory Unit. Paris, France.
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spelling Bourhy, LenaMazeraud, AurélienBozza, Fernando A.Turc, GuillaumeLledo, Pierre-MarieSharshar, Tarek2022-06-27T23:34:05Z2022-06-27T23:34:05Z2022BOURHY, Lena et al. Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke. Frontiers in Immunology, v. 13, p. 1-10, 2022.1664-3224https://www.arca.fiocruz.br/handle/icict/5355310.3389/fimmu.2022.834649engFrontiers MediaNeuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Strokeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstitut Pasteur. Université de Paris. Centre National de Recherche Scientifique. Unité Mixte de Recherche (CNRS UMR) 3571. Perception and Memory Unit. Paris, France.Institut Pasteur. Université de Paris. Centre National de Recherche Scientifique. Unité Mixte de Recherche (CNRS UMR) 3571. Perception and Memory Unit. Paris, France / Université de Paris. Groupe Hospitalier Universitaire (GHU) Paris Psychiatrie et Neurosciences. Neuro-Anesthesiology and Intensive Care Medicine. Paris, France.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.Université de Paris. GHU Paris Psychiatrie et Neurosciences. Department of Neurology. Paris, France.Institut Pasteur. Université de Paris. Centre National de Recherche Scientifique. Unité Mixte de Recherche (CNRS UMR) 3571. Perception and Memory Unit. Paris, France.Université de Paris. Groupe Hospitalier Universitaire (GHU) Paris Psychiatrie et Neurosciences. Neuro-Anesthesiology and Intensive Care Medicine. Paris, France.Despite recent therapeutic advances, ischemic stroke is still a leading cause of death and disability. There is renewed attention on peripheral inflammatory signaling as a way of modulating the post-ischemic neuro-inflammatory process. The immune-brain crosstalk has long been the focus for understanding the mechanisms of sickness behavior, which is an adaptive autonomic, neuroendocrine, and behavioral response to a peripheral inflammation. It is mediated by humoral and neural pathways that mainly involve the circumventricular organs and vagal nerve, respectively. In this review we address the question of how sepsis and stroke can dysregulate this adaptive response, notably by impairing the central integration of peripheral signaling, but also by efferent control of the immune response. We highlight the potential role of gut-brain and brain-spleen signaling in stroke.Immune responseIschemic strokeNeuromodulationSepsisSickness behaviorinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/53553/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALNeuro_Fernando_Bozza_etal_INI_2022.pdfNeuro_Fernando_Bozza_etal_INI_2022.pdfapplication/pdf1367484https://www.arca.fiocruz.br/bitstream/icict/53553/2/Neuro_Fernando_Bozza_etal_INI_2022.pdf05426bf2c1c4e54c6d0ec40fb884e48aMD52icict/535532023-02-26 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dc.title.pt_BR.fl_str_mv Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke
title Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke
spellingShingle Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke
Bourhy, Lena
Immune response
Ischemic stroke
Neuromodulation
Sepsis
Sickness behavior
title_short Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke
title_full Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke
title_fullStr Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke
title_full_unstemmed Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke
title_sort Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke
author Bourhy, Lena
author_facet Bourhy, Lena
Mazeraud, Aurélien
Bozza, Fernando A.
Turc, Guillaume
Lledo, Pierre-Marie
Sharshar, Tarek
author_role author
author2 Mazeraud, Aurélien
Bozza, Fernando A.
Turc, Guillaume
Lledo, Pierre-Marie
Sharshar, Tarek
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Bourhy, Lena
Mazeraud, Aurélien
Bozza, Fernando A.
Turc, Guillaume
Lledo, Pierre-Marie
Sharshar, Tarek
dc.subject.en.pt_BR.fl_str_mv Immune response
Ischemic stroke
Neuromodulation
Sepsis
Sickness behavior
topic Immune response
Ischemic stroke
Neuromodulation
Sepsis
Sickness behavior
description Institut Pasteur. Université de Paris. Centre National de Recherche Scientifique. Unité Mixte de Recherche (CNRS UMR) 3571. Perception and Memory Unit. Paris, France.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-06-27T23:34:05Z
dc.date.available.fl_str_mv 2022-06-27T23:34:05Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BOURHY, Lena et al. Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke. Frontiers in Immunology, v. 13, p. 1-10, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/53553
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2022.834649
identifier_str_mv BOURHY, Lena et al. Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke. Frontiers in Immunology, v. 13, p. 1-10, 2022.
1664-3224
10.3389/fimmu.2022.834649
url https://www.arca.fiocruz.br/handle/icict/53553
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/53553/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/53553/2/Neuro_Fernando_Bozza_etal_INI_2022.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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