Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1590/0074-0276140266 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7587 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Recife, PE, Brasil. |
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Barros, Andréia Ferreira deOliveira, Sheilla Andrade deCarvalho, Camila LimaSilva, Fabiana LeticiaSouza, Veruska Cintia Alexandrino deSilva, Anekecia Lauro daAraújo, Roni Evencio deSouza, Bruno Solano de FreitasSoares, Milena Botelho PereiraCosta, Vlaudia M. AssisCoutinho, Eridan de Medeiros2014-05-06T19:12:07Z2014-05-06T19:12:07Z2014BARROS, Andréia Ferreira de et al. Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, n. 1, p. 1-10, 2014.0074-0276https://www.arca.fiocruz.br/handle/icict/758710.1590/0074-0276140266engFiocruzLow transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Recife, PE, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Recife, PE, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Recife, PE, Brasil.Universidade Federal de Pernambuco. Departamento de Medicina Tropical. Centro de Ciências da Saúde. Recife, PE, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Recife, PE, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Recife, PE, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Recife, PE, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil / Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil / Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, Brasil.Universidade Federal de Pernambuco. Departamento de Medicina Tropical. Centro de Ciências da Saúde. Recife, PE, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Recife, PE, Brasil.Undernourished mice infected (UI) submitted to low and long-lasting infections by Schistosoma mansoni are unable to develop the hepatic periportal fibrosis that is equivalent to Symmers’ fibrosis in humans. In this report, the effects of the host’s nutritional status on parasite (worm load, egg viability and maturation) and host (growth curves, biology, collagen synthesis and characteristics of the immunological response) were studied and these are considered as interdependent factors influencing the amount and distribution of fibrous tissue in hepatic periovular granulomas and portal spaces. The nutritional status of the host influenced the low body weight and low parasite burden detected in UI mice as well as the number, viability and maturation of released eggs. The reduced oviposition and increased number of degenerated or dead eggs were associated with low protein synthesis detected in deficient hosts, which likely induced the observed decrease in transformation growth factor (TGF)-β1 and liver collagen. Despite the reduced number of mature eggs in UI mice, the activation of TGF-β1 and hepatic stellate cells occurred regardless of the unviability of most miracidia, due to stimulation by fibrogenic proteins and eggshell glycoproteins. However, changes in the repair mechanisms influenced by the nutritional status in deficient animals may account for the decreased liver collagen detected in the present study.Schistosomiasis mansoniCytokinesUndernutritionLiver fibrosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBarros AF Low tranformation....pdfBarros AF Low tranformation....pdfapplication/pdf1467776https://www.arca.fiocruz.br/bitstream/icict/7587/1/Barros%20AF%20Low%20tranformation....pdf0d1f3ebc02c562613386285d81b68bb9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7587/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTBarros AF Low tranformation....pdf.txtBarros AF Low tranformation....pdf.txtExtracted texttext/plain44861https://www.arca.fiocruz.br/bitstream/icict/7587/5/Barros%20AF%20Low%20tranformation....pdf.txte496bbe6963fa418563872a791f5d1ffMD55THUMBNAILBarros AF Low tranformation....pdf.jpgBarros AF Low tranformation....pdf.jpgGenerated Thumbnailimage/jpeg2250https://www.arca.fiocruz.br/bitstream/icict/7587/4/Barros%20AF%20Low%20tranformation....pdf.jpg70dd52b8bb9a9b3590ba96cca021e5d4MD54icict/75872023-03-15 14:34:15.367oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:15Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni |
| title |
Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni |
| spellingShingle |
Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni Barros, Andréia Ferreira de Schistosomiasis mansoni Cytokines Undernutrition Liver fibrosis |
| title_short |
Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni |
| title_full |
Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni |
| title_fullStr |
Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni |
| title_full_unstemmed |
Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni |
| title_sort |
Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni |
| author |
Barros, Andréia Ferreira de |
| author_facet |
Barros, Andréia Ferreira de Oliveira, Sheilla Andrade de Carvalho, Camila Lima Silva, Fabiana Leticia Souza, Veruska Cintia Alexandrino de Silva, Anekecia Lauro da Araújo, Roni Evencio de Souza, Bruno Solano de Freitas Soares, Milena Botelho Pereira Costa, Vlaudia M. Assis Coutinho, Eridan de Medeiros |
| author_role |
author |
| author2 |
Oliveira, Sheilla Andrade de Carvalho, Camila Lima Silva, Fabiana Leticia Souza, Veruska Cintia Alexandrino de Silva, Anekecia Lauro da Araújo, Roni Evencio de Souza, Bruno Solano de Freitas Soares, Milena Botelho Pereira Costa, Vlaudia M. Assis Coutinho, Eridan de Medeiros |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barros, Andréia Ferreira de Oliveira, Sheilla Andrade de Carvalho, Camila Lima Silva, Fabiana Leticia Souza, Veruska Cintia Alexandrino de Silva, Anekecia Lauro da Araújo, Roni Evencio de Souza, Bruno Solano de Freitas Soares, Milena Botelho Pereira Costa, Vlaudia M. Assis Coutinho, Eridan de Medeiros |
| dc.subject.en.pt_BR.fl_str_mv |
Schistosomiasis mansoni Cytokines Undernutrition Liver fibrosis |
| topic |
Schistosomiasis mansoni Cytokines Undernutrition Liver fibrosis |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Recife, PE, Brasil. |
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2014 |
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2014-05-06T19:12:07Z |
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2014-05-06T19:12:07Z |
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2014 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
BARROS, Andréia Ferreira de et al. Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, n. 1, p. 1-10, 2014. |
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https://www.arca.fiocruz.br/handle/icict/7587 |
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0074-0276 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/0074-0276140266 |
| identifier_str_mv |
BARROS, Andréia Ferreira de et al. Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, n. 1, p. 1-10, 2014. 0074-0276 10.1590/0074-0276140266 |
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Fiocruz |
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