Sepsis-associated outcomes in critically ill patients with malignancies

Detalhes bibliográficos
Autor(a) principal: Torres, Viviane B. L.
Data de Publicação: 2015
Outros Autores: Azevedo, Luciano C. P., Silva, Ulysses V. A., Caruso, Pedro, Torelly, André P., Silva, Eliezer, Carvalho, Frederico B., Vianna, Arthur, Souza, Paulo C. P., Godoy, Michele M. G., Azevedo, José R. A., Spector, Nelson, Bozza, Fernando A., Salluh, Jorge I. F., Soares, Marcio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34733
Resumo: 2020-08-12
id CRUZ_a09d3c06eb225932a50ba2cf701225fb
oai_identifier_str oai:www.arca.fiocruz.br:icict/34733
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Torres, Viviane B. L.Azevedo, Luciano C. P.Silva, Ulysses V. A.Caruso, PedroTorelly, André P.Silva, EliezerCarvalho, Frederico B.Vianna, ArthurSouza, Paulo C. P.Godoy, Michele M. G.Azevedo, José R. A.Spector, NelsonBozza, Fernando A.Salluh, Jorge I. F.Soares, Marcio2019-08-12T14:34:05Z2019-08-12T14:34:05Z2015TORRES, Viviane B. L. et al. Sepsis-associated outcomes in critically ill patients with malignancies. Annals of the American Thoracic Society, v. 12, n. 8, p. 1185-1192, Aug. 2015.2329-6933https://www.arca.fiocruz.br/handle/icict/3473310.1513/AnnalsATS.201501-046OC2325-6621engAmerican Thoracic SocietySepsis-associated outcomes in critically ill patients with malignanciesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-08-12Universidade Federal do Rio de Janeiro. School of Medicine. Postgraduate Program in Internal Medicine. Rio de Janeiro, RJ, Brazil.National Cancer Institute. Postgraduate Program. Rio de Janeiro, RJ, Brazil / Hospital Sírio-Libanês. Research and Education Institute. São Paulo, SP, Brazil.Pio XII Foundation. Hospital do Câncer de Barretos. ICU. Barretos, SP, Brazil.A.C. Camargo Cancer Center. ICU. São Paulo, SP, Brazil.Irmandade da Santa Casa de Misericórdia de Porto Alegre. Rede Institucional de Pesquisa e Inovação em Medicina Intensiva. Porto Alegre, RS, Brasil.Hospital Israelita Albert Einstein. ICU. São Paulo, SP, Brazil.Hospital Mater Dei. ICU. Belo Horizonte, MG, Brazil.Clinica São Vicente. ICU. Rio de Janeiro, RJ, Brazil.Hospital de Clinicas de Niteroi. ICU. Niteroi, RJ, Brazil.Universidade Federal de Pernambuco. Hospital de Clinicas. Recife, PE, Brazil.Hospital São Domingos-São Luís. ICU. São Luís, MA, Brazil.Universidade Federal do Rio de Janeiro. School of Medicine. Postgraduate Program in Internal Medicine. Rio de Janeiro, RJ, Brazil.D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. School of Medicine. Postgraduate Program in Internal Medicine. Rio de Janeiro, RJ, Brazil / National Cancer Institute. Postgraduate Program. Rio de Janeiro, RJ, Brazil / D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. School of Medicine. Postgraduate Program in Internal Medicine. Rio de Janeiro, RJ, Brazil / National Cancer Institute. Postgraduate Program. Rio de Janeiro, RJ, Brazil / D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.Rationale: Sepsis is a major cause of mortality among critically ill patients with cancer. Information about clinical outcomes and factors associated with increased risk of death in these patients is necessary to help physicians recognize those patients who are most likely to benefit from ICU therapy and identify possible targets for intervention. Objectives: In this study, we evaluated cancer patients with sepsis chosen from a multicenter prospective study to characterize their clinical characteristics and to identify independent risk factors associated with hospital mortality. Methods: Subgroup analysis of a multicenter prospective cohort study conducted in 28 Brazilian intensive care units (ICUs) to evaluate adult cancer patients with severe sepsis and septic shock. We used logistic regression to identify variables associated with hospital mortality. Measurements and Main Results: Of the 717 patients admitted to the participating ICUs, 268 (37%) had severe sepsis (n = 142, 53%) or septic shock (n = 126, 47%). These patients comprised the population of the present study. The mean score on the third version of the Simplified Acute Physiology Score was 62.9 6 17.7 points, and the median Sequential Organ Failure Assessment score was 9 (7–12) points. The most frequent sites of infection were the lungs (48%), intraabdominal region (25%), bloodstream as primary infection (19%), and urinary tract (17%). Half of the patients had microbiologically proven infections, and Gram-negative bacteria were the most common pathogens causing sepsis (31%). ICU and hospital mortality rates were 42% and 56%, respectively. In multivariable analysis, the number of acute organ dysfunctions (odds ratio [OR], 1.48; 95% confidence interval [CI], 1.16–1.87), hematological malignancies (OR, 2.57; 95% CI, 1.05–6.27), performance status 2–4 (OR, 2.53; 95% CI, 1.44–4.43), and polymicrobial infections (OR, 3.74; 95% CI, 1.52–9.21) were associated with hospital mortality. Conclusions: Sepsis is a common cause of critical illness in patients with cancer and remains associated with high mortality. Variables related to underlying malignancy, sepsis severity, and characteristics of infection are associated with a grim prognosis.CancerInfectionIntensive careMalignancySepsisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/34733/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Torres_Viviane_etal_INI_2015.pdfve_Torres_Viviane_etal_INI_2015.pdfapplication/pdf541628https://www.arca.fiocruz.br/bitstream/icict/34733/2/ve_Torres_Viviane_etal_INI_2015.pdf87f43b767142e9b3c9dd77871b342ed8MD52TEXTve_Torres_Viviane_etal_INI_2015.pdf.txtve_Torres_Viviane_etal_INI_2015.pdf.txtExtracted texttext/plain40082https://www.arca.fiocruz.br/bitstream/icict/34733/3/ve_Torres_Viviane_etal_INI_2015.pdf.txt78d811febd986bb7a9b74471b0c2d760MD53icict/347332021-03-24 16:32:35.198oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:35Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Sepsis-associated outcomes in critically ill patients with malignancies
title Sepsis-associated outcomes in critically ill patients with malignancies
spellingShingle Sepsis-associated outcomes in critically ill patients with malignancies
Torres, Viviane B. L.
Cancer
Infection
Intensive care
Malignancy
Sepsis
title_short Sepsis-associated outcomes in critically ill patients with malignancies
title_full Sepsis-associated outcomes in critically ill patients with malignancies
title_fullStr Sepsis-associated outcomes in critically ill patients with malignancies
title_full_unstemmed Sepsis-associated outcomes in critically ill patients with malignancies
title_sort Sepsis-associated outcomes in critically ill patients with malignancies
author Torres, Viviane B. L.
author_facet Torres, Viviane B. L.
Azevedo, Luciano C. P.
Silva, Ulysses V. A.
Caruso, Pedro
Torelly, André P.
Silva, Eliezer
Carvalho, Frederico B.
Vianna, Arthur
Souza, Paulo C. P.
Godoy, Michele M. G.
Azevedo, José R. A.
Spector, Nelson
Bozza, Fernando A.
Salluh, Jorge I. F.
Soares, Marcio
author_role author
author2 Azevedo, Luciano C. P.
Silva, Ulysses V. A.
Caruso, Pedro
Torelly, André P.
Silva, Eliezer
Carvalho, Frederico B.
Vianna, Arthur
Souza, Paulo C. P.
Godoy, Michele M. G.
Azevedo, José R. A.
Spector, Nelson
Bozza, Fernando A.
Salluh, Jorge I. F.
Soares, Marcio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Torres, Viviane B. L.
Azevedo, Luciano C. P.
Silva, Ulysses V. A.
Caruso, Pedro
Torelly, André P.
Silva, Eliezer
Carvalho, Frederico B.
Vianna, Arthur
Souza, Paulo C. P.
Godoy, Michele M. G.
Azevedo, José R. A.
Spector, Nelson
Bozza, Fernando A.
Salluh, Jorge I. F.
Soares, Marcio
dc.subject.en.pt_BR.fl_str_mv Cancer
Infection
Intensive care
Malignancy
Sepsis
topic Cancer
Infection
Intensive care
Malignancy
Sepsis
description 2020-08-12
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-08-12T14:34:05Z
dc.date.available.fl_str_mv 2019-08-12T14:34:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TORRES, Viviane B. L. et al. Sepsis-associated outcomes in critically ill patients with malignancies. Annals of the American Thoracic Society, v. 12, n. 8, p. 1185-1192, Aug. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34733
dc.identifier.issn.pt_BR.fl_str_mv 2329-6933
dc.identifier.doi.none.fl_str_mv 10.1513/AnnalsATS.201501-046OC
dc.identifier.eissn.none.fl_str_mv 2325-6621
identifier_str_mv TORRES, Viviane B. L. et al. Sepsis-associated outcomes in critically ill patients with malignancies. Annals of the American Thoracic Society, v. 12, n. 8, p. 1185-1192, Aug. 2015.
2329-6933
10.1513/AnnalsATS.201501-046OC
2325-6621
url https://www.arca.fiocruz.br/handle/icict/34733
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Thoracic Society
publisher.none.fl_str_mv American Thoracic Society
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/34733/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/34733/2/ve_Torres_Viviane_etal_INI_2015.pdf
https://www.arca.fiocruz.br/bitstream/icict/34733/3/ve_Torres_Viviane_etal_INI_2015.pdf.txt
bitstream.checksum.fl_str_mv 79178e5f2a0eb066867a274556814938
87f43b767142e9b3c9dd77871b342ed8
78d811febd986bb7a9b74471b0c2d760
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324873391505408

Registros relacionados