Four months of rifampin or nine months of isoniazid for latent tuberculosis in adults
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/33753 |
Resumo: | Valéria Rolla. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Centre Research Institute (D.M., A.T., C.V., K.H., M.-J.D., P.Z.L., K.S., A.B.), and the Department of Epidemiology and Biostatistics (D.M., A.B.), McGill University, Montreal, the Faculty of Medicine and Dentistry, University of Alberta, Edmonton (R.L.), the Faculty of Medicine, University of Saskatchewan, Saskatoon (V.H.), and the BC Centre for Disease Control and the University of British Columbia, Vancouver (K.E., V.J.C.) — all in Canada; Centre National Hospitalier Universitaire de Pneumo-Phtisiologie, Cotonou, Benin (M.A., M.G.); the Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia (R.R., L.A., R.C.K.); State University of Rio de Janeiro (A.T.), Programa Academico de Tuberculose–Faculdade de Medicina, Universidade Federal do Rio de Janeiro–Rede TB (A.K.), and National Institute of Infectious Diseases Evandro Chagas (V.R.) — all in Rio de Janeiro; Service de Pneumophtisiologie, Hôpital National Ignace Deen, Université Gamal Abdel Nasser de Conakry, Conakry, Guinea (O.S., B.B., A.C.); Korean Institute of Tuberculosis, Seoul, South Korea (H.K.); Komfo Anokye Teaching Hospital, Kumasi, Ghana (J.O.B., I.B.); University of New South Wales (G.B.M.) and University of Sydney (H.G.), Sydney; Centre for International Health, University of Otago, Dunedin, New Zealand (P.C.H.); and the Department of Medicine, King Saud University, King Abdulaziz Medical City, Riyadh, Saudi Arabia (H.A.-J.). |
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Menzies, DickAdjobimey, MenonliRuslami, RovinaTrajman, AneteSow, OumouKim, HeejinObeng Baah, JosephMarks, Guy B.Long, RichardHoeppner, VernonElwood, KevinAl-Jahdali, HamdanGninafon, MartinApriani, LikaKoesoemadinata, Raspati C.Kritski, AfranioRolla, ValeriaBah, BoubacarCamara, AliouneBoakye, IsaacCook, Victoria J.Goldberg, HazelValiquette, ChantalHornby, KarenDion, Marie-JoséeLi, Pei-ZhiHill, Philip C.Schwartzman, KevinBenedetti, Andrea2019-07-01T14:39:44Z2019-07-01T14:39:44Z2018MENZIES, D. et al. Four months of rifampin or nine months of isoniazid for latent tuberculosis in adults. New England Journal of Medicine, v. 379, n. 5, p. 440-453, Aug. 2 2018.0028-4793https://www.arca.fiocruz.br/handle/icict/3375310.1056/NEJMoa17142831533-4406Valéria Rolla. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Centre Research Institute (D.M., A.T., C.V., K.H., M.-J.D., P.Z.L., K.S., A.B.), and the Department of Epidemiology and Biostatistics (D.M., A.B.), McGill University, Montreal, the Faculty of Medicine and Dentistry, University of Alberta, Edmonton (R.L.), the Faculty of Medicine, University of Saskatchewan, Saskatoon (V.H.), and the BC Centre for Disease Control and the University of British Columbia, Vancouver (K.E., V.J.C.) — all in Canada; Centre National Hospitalier Universitaire de Pneumo-Phtisiologie, Cotonou, Benin (M.A., M.G.); the Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia (R.R., L.A., R.C.K.); State University of Rio de Janeiro (A.T.), Programa Academico de Tuberculose–Faculdade de Medicina, Universidade Federal do Rio de Janeiro–Rede TB (A.K.), and National Institute of Infectious Diseases Evandro Chagas (V.R.) — all in Rio de Janeiro; Service de Pneumophtisiologie, Hôpital National Ignace Deen, Université Gamal Abdel Nasser de Conakry, Conakry, Guinea (O.S., B.B., A.C.); Korean Institute of Tuberculosis, Seoul, South Korea (H.K.); Komfo Anokye Teaching Hospital, Kumasi, Ghana (J.O.B., I.B.); University of New South Wales (G.B.M.) and University of Sydney (H.G.), Sydney; Centre for International Health, University of Otago, Dunedin, New Zealand (P.C.H.); and the Department of Medicine, King Saud University, King Abdulaziz Medical City, Riyadh, Saudi Arabia (H.A.-J.).2020-01-01Múltipla - Ver em Notas.BACKGROUND: A 9-month regimen of isoniazid can prevent active tuberculosis in persons with latent tuberculosis infection. However, the regimen has been associated with poor adherence rates and with toxic effects. METHODS: In an open-label trial conducted in nine countries, we randomly assigned adults with latent tuberculosis infection to receive treatment with a 4-month regimen of rifampin or a 9-month regimen of isoniazid for the prevention of confirmed active tuberculosis within 28 months after randomization. Noninferiority and potential superiority were assessed. Secondary outcomes included clinically diagnosed active tuberculosis, adverse events of grades 3 to 5, and completion of the treatment regimen. Outcomes were adjudicated by independent review panels. RESULTS: Among the 3443 patients in the rifampin group, confirmed active tuberculosis developed in 4 and clinically diagnosed active tuberculosis developed in 4 during 7732 person-years of follow-up, as compared with 4 and 5 patients, respectively, among 3416 patients in the isoniazid group during 7652 person-years of follow-up. The rate differences (rifampin minus isoniazid) were less than 0.01 cases per 100 person-years (95% confidence interval [CI], −0.14 to 0.16) for confirmed active tuberculosis and less than 0.01 cases per 100 person-years (95% CI, −0.23 to 0.22) for confirmed or clinically diagnosed tuberculosis. The upper boundaries of the 95% confidence interval for the rate differences of the confirmed cases and for the confirmed or clinically diagnosed cases of tuberculosis were less than the prespecified noninferiority margin of 0.75 percentage points in cumulative incidence; the rifampin regimen was not superior to the isoniazid regimen. The difference in the treatment-completion rates was 15.1 percentage points (95% CI, 12.7 to 17.4). The rate differences for adverse events of grade 3 to 5 occurring within 146 days (120% of the 4-month planned duration of the rifampin regimen) were −1.1 percentage points (95% CI, −1.9 to −0.4) for all events and −1.2 percentage points (95% CI, −1.7 to −0.7) for hepatotoxic events. CONCLUSIONS: The 4-month regimen of rifampin was not inferior to the 9-month regimen of isoniazid for the prevention of active tuberculosis and was associated with a higher rate of treatment completion and better safety.engMassachusetts Medical SocietyFour months of rifampin or nine months of isoniazid for latent tuberculosis in adultsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleTuberculosisLatent tuberculosis in adultsRifampinIsoniazidinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Four months of rifampin or nine months of isoniazid for latent tuberculosis in adults |
title |
Four months of rifampin or nine months of isoniazid for latent tuberculosis in adults |
spellingShingle |
Four months of rifampin or nine months of isoniazid for latent tuberculosis in adults Menzies, Dick Tuberculosis Latent tuberculosis in adults Rifampin Isoniazid |
title_short |
Four months of rifampin or nine months of isoniazid for latent tuberculosis in adults |
title_full |
Four months of rifampin or nine months of isoniazid for latent tuberculosis in adults |
title_fullStr |
Four months of rifampin or nine months of isoniazid for latent tuberculosis in adults |
title_full_unstemmed |
Four months of rifampin or nine months of isoniazid for latent tuberculosis in adults |
title_sort |
Four months of rifampin or nine months of isoniazid for latent tuberculosis in adults |
author |
Menzies, Dick |
author_facet |
Menzies, Dick Adjobimey, Menonli Ruslami, Rovina Trajman, Anete Sow, Oumou Kim, Heejin Obeng Baah, Joseph Marks, Guy B. Long, Richard Hoeppner, Vernon Elwood, Kevin Al-Jahdali, Hamdan Gninafon, Martin Apriani, Lika Koesoemadinata, Raspati C. Kritski, Afranio Rolla, Valeria Bah, Boubacar Camara, Alioune Boakye, Isaac Cook, Victoria J. Goldberg, Hazel Valiquette, Chantal Hornby, Karen Dion, Marie-Josée Li, Pei-Zhi Hill, Philip C. Schwartzman, Kevin Benedetti, Andrea |
author_role |
author |
author2 |
Adjobimey, Menonli Ruslami, Rovina Trajman, Anete Sow, Oumou Kim, Heejin Obeng Baah, Joseph Marks, Guy B. Long, Richard Hoeppner, Vernon Elwood, Kevin Al-Jahdali, Hamdan Gninafon, Martin Apriani, Lika Koesoemadinata, Raspati C. Kritski, Afranio Rolla, Valeria Bah, Boubacar Camara, Alioune Boakye, Isaac Cook, Victoria J. Goldberg, Hazel Valiquette, Chantal Hornby, Karen Dion, Marie-Josée Li, Pei-Zhi Hill, Philip C. Schwartzman, Kevin Benedetti, Andrea |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Menzies, Dick Adjobimey, Menonli Ruslami, Rovina Trajman, Anete Sow, Oumou Kim, Heejin Obeng Baah, Joseph Marks, Guy B. Long, Richard Hoeppner, Vernon Elwood, Kevin Al-Jahdali, Hamdan Gninafon, Martin Apriani, Lika Koesoemadinata, Raspati C. Kritski, Afranio Rolla, Valeria Bah, Boubacar Camara, Alioune Boakye, Isaac Cook, Victoria J. Goldberg, Hazel Valiquette, Chantal Hornby, Karen Dion, Marie-Josée Li, Pei-Zhi Hill, Philip C. Schwartzman, Kevin Benedetti, Andrea |
dc.subject.en.pt_BR.fl_str_mv |
Tuberculosis Latent tuberculosis in adults Rifampin Isoniazid |
topic |
Tuberculosis Latent tuberculosis in adults Rifampin Isoniazid |
description |
Valéria Rolla. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Centre Research Institute (D.M., A.T., C.V., K.H., M.-J.D., P.Z.L., K.S., A.B.), and the Department of Epidemiology and Biostatistics (D.M., A.B.), McGill University, Montreal, the Faculty of Medicine and Dentistry, University of Alberta, Edmonton (R.L.), the Faculty of Medicine, University of Saskatchewan, Saskatoon (V.H.), and the BC Centre for Disease Control and the University of British Columbia, Vancouver (K.E., V.J.C.) — all in Canada; Centre National Hospitalier Universitaire de Pneumo-Phtisiologie, Cotonou, Benin (M.A., M.G.); the Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia (R.R., L.A., R.C.K.); State University of Rio de Janeiro (A.T.), Programa Academico de Tuberculose–Faculdade de Medicina, Universidade Federal do Rio de Janeiro–Rede TB (A.K.), and National Institute of Infectious Diseases Evandro Chagas (V.R.) — all in Rio de Janeiro; Service de Pneumophtisiologie, Hôpital National Ignace Deen, Université Gamal Abdel Nasser de Conakry, Conakry, Guinea (O.S., B.B., A.C.); Korean Institute of Tuberculosis, Seoul, South Korea (H.K.); Komfo Anokye Teaching Hospital, Kumasi, Ghana (J.O.B., I.B.); University of New South Wales (G.B.M.) and University of Sydney (H.G.), Sydney; Centre for International Health, University of Otago, Dunedin, New Zealand (P.C.H.); and the Department of Medicine, King Saud University, King Abdulaziz Medical City, Riyadh, Saudi Arabia (H.A.-J.). |
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2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-07-01T14:39:44Z |
dc.date.available.fl_str_mv |
2019-07-01T14:39:44Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
MENZIES, D. et al. Four months of rifampin or nine months of isoniazid for latent tuberculosis in adults. New England Journal of Medicine, v. 379, n. 5, p. 440-453, Aug. 2 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/33753 |
dc.identifier.issn.pt_BR.fl_str_mv |
0028-4793 |
dc.identifier.doi.none.fl_str_mv |
10.1056/NEJMoa1714283 |
dc.identifier.eissn.none.fl_str_mv |
1533-4406 |
identifier_str_mv |
MENZIES, D. et al. Four months of rifampin or nine months of isoniazid for latent tuberculosis in adults. New England Journal of Medicine, v. 379, n. 5, p. 440-453, Aug. 2 2018. 0028-4793 10.1056/NEJMoa1714283 1533-4406 |
url |
https://www.arca.fiocruz.br/handle/icict/33753 |
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eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Massachusetts Medical Society |
publisher.none.fl_str_mv |
Massachusetts Medical Society |
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