On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/34291 |
Resumo: | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil. |
| id |
CRUZ_a1cd94ad7cf3defd958d81ba41131e9a |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/34291 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Hojo-Souza, N. S.Pereira, D. B.Souza, F. S H. deMendes, T. A. de OliveiraCardoso, M. S.Tada, M. S.Zanini, G. M.Bartholomeu, D. C.Fujiwara, R. T.Bueno, L. L.2019-07-19T14:44:09Z2019-07-19T14:44:09Z2017HOJO-SOUZA, Natália Satchiko et al. On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease. Malaria Journal, v. 16, p. 1-10, 2017.1475-2875https://www.arca.fiocruz.br/handle/icict/3429110.1186/s12936-017-1683-51475-2875engBMCOn the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.Universidade Federal de São João del-Rei. Departamento de Ciência da Computação. São João del Rei, MG, Brasil.Universidade Federal de Viçosa. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Background: The clinical outcome of malaria depends on the delicate balance between pro-inflammatory and immunomodulatory cytokine responses triggered during infection. Despite the numerous reports on characterization of plasma levels of cytokines/chemokines, there is no consensus on the profile of these mediators during blood stage malaria. The identification of acute phase biomarkers might contribute to a better understanding of the disease, allowing the use of more effective therapeutic approaches to prevent the progression towards severe disease. In the present study, the plasma levels of cytokines and chemokines and their association with parasitaemia and number of previous malaria episodes were evaluated in Plasmodium vivax-infected patients during acute and convalescence phase, as well as in healthy donors. Methods: Samples of plasma were obtained from peripheral blood samples from four different groups: P. vivaxinfected, P. vivax-treated, endemic control and malaria-naïve control. The cytokine (IL-6, IL-10, IL-17, IL-27, TGF-β, IFN-γ and TNF) and chemokine (MCP-1/CCL2, IP-10/CXCL10 and RANTES/CCL5) plasma levels were measured by CBA or ELISA. The network analysis was performed using Spearman correlation coefficient. Results: Plasmodium vivax infection induced a pro-inflammatory response driven by IL-6 and IL-17 associated with an immunomodulatory profile mediated by IL-10 and TGF-β. In addition, a reduction was observed of IFN-γ plasma levels in P. vivax group. A lower level of IL-27 was observed in endemic control group in comparison to malaria-naïve control group. No significant results were found for IL-12p40 and TNF. It was also observed that P. vivax infection promoted higher levels of MCP-1/CCL2 and IP-10/CXCL10 and lower levels of RANTES/CCL5. The plasma level of IL-10 was elevated in patients with high parasitaemia and with more than five previous malaria episodes. Furthermore, association profile between cytokine and chemokine levels were observed by correlation network analysis indicating signature patterns associated with different parasitaemia levels. Conclusions: The P. vivax infection triggers a balanced immune response mediated by IL-6 and MCP-1/CCL2, which is modulated by IL-10. In addition, the results indicated that IL-10 plasma levels are influenced by parasitaemia and number of previous malaria episodes.Plasmodium vivaxMalariaCytokinesChemokinesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/34291/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Hojo‑Souza_Natália_etal_INI_2017.pdfve_Hojo‑Souza_Natália_etal_INI_2017.pdfapplication/pdf1495248https://www.arca.fiocruz.br/bitstream/icict/34291/2/ve_Hojo%e2%80%91Souza_Nat%c3%a1lia_etal_INI_2017.pdf0d7b943990ecea68008c416787909b4cMD52TEXTve_Hojo‑Souza_Natália_etal_INI_2017.pdf.txtve_Hojo‑Souza_Natália_etal_INI_2017.pdf.txtExtracted texttext/plain46071https://www.arca.fiocruz.br/bitstream/icict/34291/3/ve_Hojo%e2%80%91Souza_Nat%c3%a1lia_etal_INI_2017.pdf.txtd8179f5a424492c990280d2661dfa9c1MD53icict/342912019-07-20 02:02:53.52oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-07-20T05:02:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease |
| title |
On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease |
| spellingShingle |
On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease Hojo-Souza, N. S. Plasmodium vivax Malaria Cytokines Chemokines |
| title_short |
On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease |
| title_full |
On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease |
| title_fullStr |
On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease |
| title_full_unstemmed |
On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease |
| title_sort |
On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease |
| author |
Hojo-Souza, N. S. |
| author_facet |
Hojo-Souza, N. S. Pereira, D. B. Souza, F. S H. de Mendes, T. A. de Oliveira Cardoso, M. S. Tada, M. S. Zanini, G. M. Bartholomeu, D. C. Fujiwara, R. T. Bueno, L. L. |
| author_role |
author |
| author2 |
Pereira, D. B. Souza, F. S H. de Mendes, T. A. de Oliveira Cardoso, M. S. Tada, M. S. Zanini, G. M. Bartholomeu, D. C. Fujiwara, R. T. Bueno, L. L. |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Hojo-Souza, N. S. Pereira, D. B. Souza, F. S H. de Mendes, T. A. de Oliveira Cardoso, M. S. Tada, M. S. Zanini, G. M. Bartholomeu, D. C. Fujiwara, R. T. Bueno, L. L. |
| dc.subject.en.pt_BR.fl_str_mv |
Plasmodium vivax Malaria Cytokines Chemokines |
| topic |
Plasmodium vivax Malaria Cytokines Chemokines |
| description |
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil. |
| publishDate |
2017 |
| dc.date.issued.fl_str_mv |
2017 |
| dc.date.accessioned.fl_str_mv |
2019-07-19T14:44:09Z |
| dc.date.available.fl_str_mv |
2019-07-19T14:44:09Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
HOJO-SOUZA, Natália Satchiko et al. On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease. Malaria Journal, v. 16, p. 1-10, 2017. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/34291 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1475-2875 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s12936-017-1683-5 |
| dc.identifier.eissn.none.fl_str_mv |
1475-2875 |
| identifier_str_mv |
HOJO-SOUZA, Natália Satchiko et al. On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease. Malaria Journal, v. 16, p. 1-10, 2017. 1475-2875 10.1186/s12936-017-1683-5 |
| url |
https://www.arca.fiocruz.br/handle/icict/34291 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
BMC |
| publisher.none.fl_str_mv |
BMC |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/34291/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/34291/2/ve_Hojo%e2%80%91Souza_Nat%c3%a1lia_etal_INI_2017.pdf https://www.arca.fiocruz.br/bitstream/icict/34291/3/ve_Hojo%e2%80%91Souza_Nat%c3%a1lia_etal_INI_2017.pdf.txt |
| bitstream.checksum.fl_str_mv |
8a4605be74aa9ea9d79846c1fba20a33 0d7b943990ecea68008c416787909b4c d8179f5a424492c990280d2661dfa9c1 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324884774846464 |