Platelets: an outlook from biology through evidence-based achievements in critical care

Detalhes bibliográficos
Autor(a) principal: Costa-Filho, Rubens C.
Data de Publicação: 2017
Outros Autores: Bozza, Fernando A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31408
Resumo: Hospital Pro Cardíaco, Department of Critical Care. Rio de Janeiro RJ, Brazil / Trombocore, Haemostasis & Thrombosis Studies with roTEM® thromboelastometry directed to critically ill patients. Rio de Janeiro RJ, Brazil.
id CRUZ_a1e562f451a167a022f60f2f0dee1a55
oai_identifier_str oai:www.arca.fiocruz.br:icict/31408
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Costa-Filho, Rubens C.Bozza, Fernando A.2019-02-05T11:03:30Z2019-02-05T11:03:30Z2017COSTA-FILHO, Rubens; BOZZA, Fernando A. Platelets: an outlook from biology through evidence-based achievements in critical care. Annals of Translational Medicine, v. 5, n. 22, p. 1-15, 2017.2305-5839https://www.arca.fiocruz.br/handle/icict/3140810.21037/atm.2017.11.042305-5847engPlatelets: an outlook from biology through evidence-based achievements in critical careinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Pro Cardíaco, Department of Critical Care. Rio de Janeiro RJ, Brazil / Trombocore, Haemostasis & Thrombosis Studies with roTEM® thromboelastometry directed to critically ill patients. Rio de Janeiro RJ, Brazil.Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro RJ, Brasil.Since the original observations by Bizzozero and Osler, we have seen tremendous advances in the understanding of platelets far beyond haemostasis and the restoration of injured endothelium. In this mini-review on platelets, we will briefly outline their historical description and the importance of their evolution, focusing on a 450 million years old living fossil of Limulus polyphemus, a marine chelicerate arthropod, which helped researchers explain the basis for the immunity role of platelets and make correlations with platelet ultrastructure and function. In addition, the impact of the Limulus Amoebocyte Lysate (LAL) test for modern medicine is highlighted. The role of platelets in cardiovascular diseases, their relevance in arterial and venous thrombosis, and the utilization of antithrombotic drugs as therapeutic agents are also reported. Furthermore, platelet receptors are crucial in aggravating or mitigating other diseases, such as cancer and infections, which can recruit cells and have numerous interactions in a process recently coined "NETosis formation", which is also briefly depicted.PlateletThrombosisAntithrombotic drugsLimulusLimulus Amoebocyte Lysate (LAL) testCancerProtease-activated receptor 1 (PAR-1)Glycoprotein (GP) Ib/IX/V complexPurinoceptorNETosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31408/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Costa-Filho_Rubens_etal_INI_2017.pdfve_Costa-Filho_Rubens_etal_INI_2017.pdfapplication/pdf3955252https://www.arca.fiocruz.br/bitstream/icict/31408/2/ve_Costa-Filho_Rubens_etal_INI_2017.pdfa52c83833ff23a0d9fa6c548c28ca2feMD52TEXTve_Costa-Filho_Rubens_etal_INI_2017.pdf.txtve_Costa-Filho_Rubens_etal_INI_2017.pdf.txtExtracted texttext/plain58468https://www.arca.fiocruz.br/bitstream/icict/31408/3/ve_Costa-Filho_Rubens_etal_INI_2017.pdf.txt056afa18e8ed3df2e66901aa6c51bd88MD53icict/314082019-02-06 02:01:49.833oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-02-06T04:01:49Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Platelets: an outlook from biology through evidence-based achievements in critical care
title Platelets: an outlook from biology through evidence-based achievements in critical care
spellingShingle Platelets: an outlook from biology through evidence-based achievements in critical care
Costa-Filho, Rubens C.
Platelet
Thrombosis
Antithrombotic drugs
Limulus
Limulus Amoebocyte Lysate (LAL) test
Cancer
Protease-activated receptor 1 (PAR-1)
Glycoprotein (GP) Ib/IX/V complex
Purinoceptor
NETosis
title_short Platelets: an outlook from biology through evidence-based achievements in critical care
title_full Platelets: an outlook from biology through evidence-based achievements in critical care
title_fullStr Platelets: an outlook from biology through evidence-based achievements in critical care
title_full_unstemmed Platelets: an outlook from biology through evidence-based achievements in critical care
title_sort Platelets: an outlook from biology through evidence-based achievements in critical care
author Costa-Filho, Rubens C.
author_facet Costa-Filho, Rubens C.
Bozza, Fernando A.
author_role author
author2 Bozza, Fernando A.
author2_role author
dc.contributor.author.fl_str_mv Costa-Filho, Rubens C.
Bozza, Fernando A.
dc.subject.en.pt_BR.fl_str_mv Platelet
Thrombosis
Antithrombotic drugs
Limulus
Limulus Amoebocyte Lysate (LAL) test
Cancer
Protease-activated receptor 1 (PAR-1)
Glycoprotein (GP) Ib/IX/V complex
Purinoceptor
NETosis
topic Platelet
Thrombosis
Antithrombotic drugs
Limulus
Limulus Amoebocyte Lysate (LAL) test
Cancer
Protease-activated receptor 1 (PAR-1)
Glycoprotein (GP) Ib/IX/V complex
Purinoceptor
NETosis
description Hospital Pro Cardíaco, Department of Critical Care. Rio de Janeiro RJ, Brazil / Trombocore, Haemostasis & Thrombosis Studies with roTEM® thromboelastometry directed to critically ill patients. Rio de Janeiro RJ, Brazil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2019-02-05T11:03:30Z
dc.date.available.fl_str_mv 2019-02-05T11:03:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA-FILHO, Rubens; BOZZA, Fernando A. Platelets: an outlook from biology through evidence-based achievements in critical care. Annals of Translational Medicine, v. 5, n. 22, p. 1-15, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31408
dc.identifier.issn.pt_BR.fl_str_mv 2305-5839
dc.identifier.doi.none.fl_str_mv 10.21037/atm.2017.11.04
dc.identifier.eissn.none.fl_str_mv 2305-5847
identifier_str_mv COSTA-FILHO, Rubens; BOZZA, Fernando A. Platelets: an outlook from biology through evidence-based achievements in critical care. Annals of Translational Medicine, v. 5, n. 22, p. 1-15, 2017.
2305-5839
10.21037/atm.2017.11.04
2305-5847
url https://www.arca.fiocruz.br/handle/icict/31408
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/31408/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/31408/2/ve_Costa-Filho_Rubens_etal_INI_2017.pdf
https://www.arca.fiocruz.br/bitstream/icict/31408/3/ve_Costa-Filho_Rubens_etal_INI_2017.pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
a52c83833ff23a0d9fa6c548c28ca2fe
056afa18e8ed3df2e66901aa6c51bd88
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009014503505920

Registros relacionados