Cell wall integrity pathway involved in morphogenesis, virulence and antifungal susceptibility in Cryptococcus neoformans

Detalhes bibliográficos
Autor(a) principal: Oliveira, Haroldo Cesar de
Data de Publicação: 2021
Outros Autores: Rossi, Suelen Andreia, García-Barbazán, Irene, Zaragoza, Óscar, Trevijano-Contador, Nuria
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/49990
Resumo: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
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spelling Oliveira, Haroldo Cesar deRossi, Suelen AndreiaGarcía-Barbazán, IreneZaragoza, ÓscarTrevijano-Contador, Nuria2021-11-23T19:29:13Z2021-11-23T19:29:13Z2021OLIVEIRA, Haroldo Cesar de et al. Cell wall integrity pathway involved in morphogenesis, virulence and antifungal susceptibility in Cryptococcus neoformans. J. Fungi, V.7, n. 831, p. 1–12, 2021.2309-608Xhttps://www.arca.fiocruz.br/handle/icict/4999010.3390/jof7100831porMDPIGTPasesCell WallCell Wall IntegrityProtein Kinase CGTP PhosphohydrolasesMorphogenesisVirulencePared CelularProteína Quinasa CGTP FosfohidrolasasMorfogénesisVirulenciaParoi cellulaireProtéine kinase CdGTPasesMorphogenèseVirulenceParede CelularProteína Quinase CGTP Fosfo-HidrolasesMorfogêneseVirulênciaCell wall integrity pathway involved in morphogenesis, virulence and antifungal susceptibility in Cryptococcus neoformansinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Instituto de Salud Carlos III. Centro Nacional de Microbiología. Laboratório de Referência e Investigación en Micología. Madrid, Spain. / Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Microbiologia. São Paulo, SP, Brasil.Instituto de Salud Carlos III. Centro Nacional de Microbiología. Laboratório de Referência e Investigación en Micología. Madrid, Spain.Instituto de Salud Carlos III. Centro Nacional de Microbiología. Laboratório de Referência e Investigación en Micología. Madrid, Spain.Instituto de Salud Carlos III. Centro Nacional de Microbiología. Laboratório de Referência e Investigación en Micología. Madrid, Spain.Due to its location, the fungal cell wall is the compartment that allows the interaction with the environment and/or the host, playing an important role during infection as well as in different biological functions such as cell morphology, cell permeability and protection against stress. All these processes involve the activation of signaling pathways within the cell. The cell wall integrity (CWI) pathway is the main route responsible for maintaining the functionality and proper structure of the cell wall. This pathway is highly conserved in the fungal kingdom and has been extensively characterized in Saccharomyces cerevisiae. However, there are still many unknown aspects of this pathway in the pathogenic fungi, such as Cryptococcus neoformans. This yeast is of particular interest because it is found in the environment, but can also behave as pathogen in multiple organisms, including vertebrates and invertebrates, so it has to adapt to multiple factors to survive in multiple niches. In this review, we summarize the components of the CWI pathway in C. neoformans as well as its involvement in different aspects such as virulence factors, morphological changes, and its role as target for antifungal therapies among others.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/49990/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALjof-07-008312OK.pdfjof-07-008312OK.pdfapplication/pdf909691https://www.arca.fiocruz.br/bitstream/icict/49990/2/jof-07-008312OK.pdf0de5e9afc802ebb2715e295ca38969d1MD52icict/499902021-11-23 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dc.title.pt_BR.fl_str_mv Cell wall integrity pathway involved in morphogenesis, virulence and antifungal susceptibility in Cryptococcus neoformans
title Cell wall integrity pathway involved in morphogenesis, virulence and antifungal susceptibility in Cryptococcus neoformans
spellingShingle Cell wall integrity pathway involved in morphogenesis, virulence and antifungal susceptibility in Cryptococcus neoformans
Oliveira, Haroldo Cesar de
GTPases
Cell Wall
Cell Wall Integrity
Protein Kinase C
GTP Phosphohydrolases
Morphogenesis
Virulence
Pared Celular
Proteína Quinasa C
GTP Fosfohidrolasas
Morfogénesis
Virulencia
Paroi cellulaire
Protéine kinase C
dGTPases
Morphogenèse
Virulence
Parede Celular
Proteína Quinase C
GTP Fosfo-Hidrolases
Morfogênese
Virulência
title_short Cell wall integrity pathway involved in morphogenesis, virulence and antifungal susceptibility in Cryptococcus neoformans
title_full Cell wall integrity pathway involved in morphogenesis, virulence and antifungal susceptibility in Cryptococcus neoformans
title_fullStr Cell wall integrity pathway involved in morphogenesis, virulence and antifungal susceptibility in Cryptococcus neoformans
title_full_unstemmed Cell wall integrity pathway involved in morphogenesis, virulence and antifungal susceptibility in Cryptococcus neoformans
title_sort Cell wall integrity pathway involved in morphogenesis, virulence and antifungal susceptibility in Cryptococcus neoformans
author Oliveira, Haroldo Cesar de
author_facet Oliveira, Haroldo Cesar de
Rossi, Suelen Andreia
García-Barbazán, Irene
Zaragoza, Óscar
Trevijano-Contador, Nuria
author_role author
author2 Rossi, Suelen Andreia
García-Barbazán, Irene
Zaragoza, Óscar
Trevijano-Contador, Nuria
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Haroldo Cesar de
Rossi, Suelen Andreia
García-Barbazán, Irene
Zaragoza, Óscar
Trevijano-Contador, Nuria
dc.subject.other.pt_BR.fl_str_mv GTPases
topic GTPases
Cell Wall
Cell Wall Integrity
Protein Kinase C
GTP Phosphohydrolases
Morphogenesis
Virulence
Pared Celular
Proteína Quinasa C
GTP Fosfohidrolasas
Morfogénesis
Virulencia
Paroi cellulaire
Protéine kinase C
dGTPases
Morphogenèse
Virulence
Parede Celular
Proteína Quinase C
GTP Fosfo-Hidrolases
Morfogênese
Virulência
dc.subject.en.pt_BR.fl_str_mv Cell Wall
Cell Wall Integrity
Protein Kinase C
GTP Phosphohydrolases
Morphogenesis
Virulence
dc.subject.es.pt_BR.fl_str_mv Pared Celular
Proteína Quinasa C
GTP Fosfohidrolasas
Morfogénesis
Virulencia
dc.subject.fr.pt_BR.fl_str_mv Paroi cellulaire
Protéine kinase C
dGTPases
Morphogenèse
Virulence
dc.subject.decs.pt_BR.fl_str_mv Parede Celular
Proteína Quinase C
GTP Fosfo-Hidrolases
Morfogênese
Virulência
description Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-11-23T19:29:13Z
dc.date.available.fl_str_mv 2021-11-23T19:29:13Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Haroldo Cesar de et al. Cell wall integrity pathway involved in morphogenesis, virulence and antifungal susceptibility in Cryptococcus neoformans. J. Fungi, V.7, n. 831, p. 1–12, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/49990
dc.identifier.issn.pt_BR.fl_str_mv 2309-608X
dc.identifier.doi.none.fl_str_mv 10.3390/jof7100831
identifier_str_mv OLIVEIRA, Haroldo Cesar de et al. Cell wall integrity pathway involved in morphogenesis, virulence and antifungal susceptibility in Cryptococcus neoformans. J. Fungi, V.7, n. 831, p. 1–12, 2021.
2309-608X
10.3390/jof7100831
url https://www.arca.fiocruz.br/handle/icict/49990
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/49990/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/49990/2/jof-07-008312OK.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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