HPLC-DAD-ESI-MS profile, antibacterial activity, and modulation of the activity of antibiotics by Carica papaya L. against Escherichia coli serotypes

Detalhes bibliográficos
Autor(a) principal: Gondim, Cícera Natalia Figueiredo Leite
Data de Publicação: 2022
Outros Autores: Bezerra, Denise Aline Casimiro, Sampaio, Nadghia Figueiredo Leite, Alencar, Maria Anésia Sousa de, Costa, Roger Henrique Sousa da, Abreu, Lucas Silva, Silva, Joanda Paolla Raimundo e, Pereira Junior, Francisco Nascimento, Tavares, Josean Fechine, Silva, Marcelo Sobral da, Ribeiro Filho, Jaime, Coutinho, Henrique Douglas Melo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55123
Resumo: Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico – FUNCAP.
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spelling Gondim, Cícera Natalia Figueiredo LeiteBezerra, Denise Aline CasimiroSampaio, Nadghia Figueiredo LeiteAlencar, Maria Anésia Sousa deCosta, Roger Henrique Sousa daAbreu, Lucas SilvaSilva, Joanda Paolla Raimundo ePereira Junior, Francisco NascimentoTavares, Josean FechineSilva, Marcelo Sobral daRibeiro Filho, JaimeCoutinho, Henrique Douglas Melo2022-10-13T14:10:13Z2022-10-13T14:10:13Z2022GONDIM, Cícera Natalia Figueiredo Leite et al. HPLC-DAD-ESI-MS profile, antibacterial activity, and modulation of the activity of antibiotics by Carica papaya L. against Escherichia coli serotypes. Phytomedicine Plus, v. 2, n. 4, p. 1-6, 2022.2667-0313https://www.arca.fiocruz.br/handle/icict/5512310.1016/j.phyplu.2022.100306Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico – FUNCAP.Universidade Federal Rural de Pernambuco. Programa de Pós-Graduação em Etnobiologia e Conservação da Natureza. Recife, PE, Brasil.Universidade Regional do Cariri. Laboratório de Microbiologia e Biologia Molecular. Crato, CE, Brasil.Universidade Regional do Cariri. Programa de Pós-Graduação em Química Biológica. Crato, CE, Brasil.Universidade Regional do Cariri. Laboratório de Microbiologia e Biologia Molecular. Crato, CE, Brasil.Universidade Federal Rural de Pernambuco. Programa de Pós-Graduação em Etnobiologia e Conservação da Natureza. Recife, PE, Brasil.Universidade Federal Fluminense Rio de Janeiro. Programa de Pós-Graduação em Química. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense Rio de Janeiro. Programa de Pós-Graduação em Química. Rio de Janeiro, RJ, Brasil.Universidade Federal da Paraíba João Pessoa. Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos. João Pessoa, PB. Brasil / Universidade Federal do Cariri. Crato, CE, Brasil.Universidade Federal da Paraíba João Pessoa. Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos. João Pessoa, PB. Brasil.Universidade Federal da Paraíba João Pessoa. Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos. João Pessoa, PB. Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal Rural de Pernambuco. Programa de Pós-Graduação em Etnobiologia e Conservação da Natureza. Recife, PE, Brasil / Universidade Regional do Cariri. Laboratório de Microbiologia e Biologia Molecular. Crato, CE, Brasil.Background: Diarrhea is currently the second leading cause of death among children under five years old in the world and therefore, remains a global public health problem. Considering that most cases of diarrhea are due to gastrointestinal infections, and medicinal plants have been traditionally used to treat such conditions, this work aimed to evaluate the chemical composition, antibacterial activity, and antibiotic-enhancing properties of C. papaya against Escherichia coli, EPEC (Enteropathogenic E. coli), and ETEC (Enterotoxigenic E. coli) serotypes. Methods: The chemical profile of the aqueous extract obtained from C. papaya leaves was determined by HPLC-DAD-ESI-MS. The antibacterial and antibiotic-enhancing activities were evaluated through the determination of the MIC, following the microdilution method. Results: A total of 17 compounds were identified by HPLC-DAD-ESI-MS. However, the extract of C. papaya did not present an intrinsic antibacterial effect, in addition to showing no modulatory effect when associated with antibiotics. Conclusions: Despite the presence of bioactive compounds, the aqueous extract C. papaya does not present antibacterial or antibiotic-enhancing effects against the ETEC and EPEC strains of E. coli. Nevertheless, further research is required to determine if its isolated components are potential drug candidates for the therapy of infections caused by these strains.engElsevierCaricaAntibiotic ResistanceCarica mamãoHPLC-DAD-ESI-MSAtividade antibacterianaResistência a antibióticosE․ coliCarica papayaHPLC-DAD-ESI-MSAntibacterial activityAntibiotic resistanceE․ coliHPLC-DAD-ESI-MS profile, antibacterial activity, and modulation of the activity of antibiotics by Carica papaya L. against Escherichia coli serotypesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGondim, Cícera - HPLC-DAD-ESI-MS profile, antibacterial activity.pdfGondim, Cícera - HPLC-DAD-ESI-MS profile, antibacterial activity.pdfapplication/pdf752313https://www.arca.fiocruz.br/bitstream/icict/55123/2/Gondim%2c%20C%c3%adcera%20-%20HPLC-DAD-ESI-MS%20profile%2c%20antibacterial%20activity.pdf44ac25e73cae32e811f58f8a65767780MD52LICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv HPLC-DAD-ESI-MS profile, antibacterial activity, and modulation of the activity of antibiotics by Carica papaya L. against Escherichia coli serotypes
title HPLC-DAD-ESI-MS profile, antibacterial activity, and modulation of the activity of antibiotics by Carica papaya L. against Escherichia coli serotypes
spellingShingle HPLC-DAD-ESI-MS profile, antibacterial activity, and modulation of the activity of antibiotics by Carica papaya L. against Escherichia coli serotypes
Gondim, Cícera Natalia Figueiredo Leite
Carica
Antibiotic Resistance
Carica mamão
HPLC-DAD-ESI-MS
Atividade antibacteriana
Resistência a antibióticos
E․ coli
Carica papaya
HPLC-DAD-ESI-MS
Antibacterial activity
Antibiotic resistance
E․ coli
title_short HPLC-DAD-ESI-MS profile, antibacterial activity, and modulation of the activity of antibiotics by Carica papaya L. against Escherichia coli serotypes
title_full HPLC-DAD-ESI-MS profile, antibacterial activity, and modulation of the activity of antibiotics by Carica papaya L. against Escherichia coli serotypes
title_fullStr HPLC-DAD-ESI-MS profile, antibacterial activity, and modulation of the activity of antibiotics by Carica papaya L. against Escherichia coli serotypes
title_full_unstemmed HPLC-DAD-ESI-MS profile, antibacterial activity, and modulation of the activity of antibiotics by Carica papaya L. against Escherichia coli serotypes
title_sort HPLC-DAD-ESI-MS profile, antibacterial activity, and modulation of the activity of antibiotics by Carica papaya L. against Escherichia coli serotypes
author Gondim, Cícera Natalia Figueiredo Leite
author_facet Gondim, Cícera Natalia Figueiredo Leite
Bezerra, Denise Aline Casimiro
Sampaio, Nadghia Figueiredo Leite
Alencar, Maria Anésia Sousa de
Costa, Roger Henrique Sousa da
Abreu, Lucas Silva
Silva, Joanda Paolla Raimundo e
Pereira Junior, Francisco Nascimento
Tavares, Josean Fechine
Silva, Marcelo Sobral da
Ribeiro Filho, Jaime
Coutinho, Henrique Douglas Melo
author_role author
author2 Bezerra, Denise Aline Casimiro
Sampaio, Nadghia Figueiredo Leite
Alencar, Maria Anésia Sousa de
Costa, Roger Henrique Sousa da
Abreu, Lucas Silva
Silva, Joanda Paolla Raimundo e
Pereira Junior, Francisco Nascimento
Tavares, Josean Fechine
Silva, Marcelo Sobral da
Ribeiro Filho, Jaime
Coutinho, Henrique Douglas Melo
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gondim, Cícera Natalia Figueiredo Leite
Bezerra, Denise Aline Casimiro
Sampaio, Nadghia Figueiredo Leite
Alencar, Maria Anésia Sousa de
Costa, Roger Henrique Sousa da
Abreu, Lucas Silva
Silva, Joanda Paolla Raimundo e
Pereira Junior, Francisco Nascimento
Tavares, Josean Fechine
Silva, Marcelo Sobral da
Ribeiro Filho, Jaime
Coutinho, Henrique Douglas Melo
dc.subject.mesh.en_US.fl_str_mv Carica
Antibiotic Resistance
topic Carica
Antibiotic Resistance
Carica mamão
HPLC-DAD-ESI-MS
Atividade antibacteriana
Resistência a antibióticos
E․ coli
Carica papaya
HPLC-DAD-ESI-MS
Antibacterial activity
Antibiotic resistance
E․ coli
dc.subject.other.en_US.fl_str_mv Carica mamão
HPLC-DAD-ESI-MS
Atividade antibacteriana
Resistência a antibióticos
E․ coli
dc.subject.en.en_US.fl_str_mv Carica papaya
HPLC-DAD-ESI-MS
Antibacterial activity
Antibiotic resistance
E․ coli
description Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico – FUNCAP.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-10-13T14:10:13Z
dc.date.available.fl_str_mv 2022-10-13T14:10:13Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GONDIM, Cícera Natalia Figueiredo Leite et al. HPLC-DAD-ESI-MS profile, antibacterial activity, and modulation of the activity of antibiotics by Carica papaya L. against Escherichia coli serotypes. Phytomedicine Plus, v. 2, n. 4, p. 1-6, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55123
dc.identifier.issn.en_US.fl_str_mv 2667-0313
dc.identifier.doi.none.fl_str_mv 10.1016/j.phyplu.2022.100306
identifier_str_mv GONDIM, Cícera Natalia Figueiredo Leite et al. HPLC-DAD-ESI-MS profile, antibacterial activity, and modulation of the activity of antibiotics by Carica papaya L. against Escherichia coli serotypes. Phytomedicine Plus, v. 2, n. 4, p. 1-6, 2022.
2667-0313
10.1016/j.phyplu.2022.100306
url https://www.arca.fiocruz.br/handle/icict/55123
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/55123/2/Gondim%2c%20C%c3%adcera%20-%20HPLC-DAD-ESI-MS%20profile%2c%20antibacterial%20activity.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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