CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/33296 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Autoimunidade e Imuno-regulação. Rio de Janeiro, RJ, Brasil. |
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Marino, A. P. M. P.Silva, A. A.Santos, P. V. A.Pinto, L. M. O.Gazinelli, R. T.Teixeira, M. M.Lannes-Vieira, Joseli2019-05-30T15:46:45Z2019-05-30T15:46:45Z2005MARINO, A. P. M. P. et al. CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl. 1, p.93-96, 2005.0074-0276https://www.arca.fiocruz.br/handle/icict/3329610.1590/S0074-027620050009000151678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzTrypanosoma cruziMiocarditeQuimiocinas CCReceptores de quimiocinas CCTrypanosoma cruziMyocarditisCC-chemokinesCC-chemokine receptorsMet-RANTESCC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Autoimunidade e Imuno-regulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Autoimunidade e Imuno-regulação. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Departamento de Patologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Departamento de Patologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunopatologia. Belo Horizonte. MG, Brasil / Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.The comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control. The augmented expression of CCL5/RANTES and CCL3/MIP-1α, and their receptor CCR5, in the heart of T. cruzi-infected mice suggests a role for CC-chemokines and their receptors in the pathogenesis of T. cruzielicited myocarditis. Herein, we discuss our recent results using a CC-chemokine receptor inhibitor (Met-RANTES), showing the participation of CC-chemokines in T. cruzi infection and unraveling CC-chemokine receptors as an attractive therapeutic target for further evaluation in Chagas disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33296/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJoseliLannes_Vieira_etal_IOC_2005.pdfJoseliLannes_Vieira_etal_IOC_2005.pdfapplication/pdf35069https://www.arca.fiocruz.br/bitstream/icict/33296/2/JoseliLannes_Vieira_etal_IOC_2005.pdfd10f2e72397da9340e1f3c5780b2681fMD52TEXTJoseliLannes_Vieira_etal_IOC_2005.pdf.txtJoseliLannes_Vieira_etal_IOC_2005.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis |
title |
CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis |
spellingShingle |
CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis Marino, A. P. M. P. Trypanosoma cruzi Miocardite Quimiocinas CC Receptores de quimiocinas CC Trypanosoma cruzi Myocarditis CC-chemokines CC-chemokine receptors Met-RANTES |
title_short |
CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis |
title_full |
CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis |
title_fullStr |
CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis |
title_full_unstemmed |
CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis |
title_sort |
CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis |
author |
Marino, A. P. M. P. |
author_facet |
Marino, A. P. M. P. Silva, A. A. Santos, P. V. A. Pinto, L. M. O. Gazinelli, R. T. Teixeira, M. M. Lannes-Vieira, Joseli |
author_role |
author |
author2 |
Silva, A. A. Santos, P. V. A. Pinto, L. M. O. Gazinelli, R. T. Teixeira, M. M. Lannes-Vieira, Joseli |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Marino, A. P. M. P. Silva, A. A. Santos, P. V. A. Pinto, L. M. O. Gazinelli, R. T. Teixeira, M. M. Lannes-Vieira, Joseli |
dc.subject.other.pt_BR.fl_str_mv |
Trypanosoma cruzi Miocardite Quimiocinas CC Receptores de quimiocinas CC |
topic |
Trypanosoma cruzi Miocardite Quimiocinas CC Receptores de quimiocinas CC Trypanosoma cruzi Myocarditis CC-chemokines CC-chemokine receptors Met-RANTES |
dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Myocarditis CC-chemokines CC-chemokine receptors Met-RANTES |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Autoimunidade e Imuno-regulação. Rio de Janeiro, RJ, Brasil. |
publishDate |
2005 |
dc.date.issued.fl_str_mv |
2005 |
dc.date.accessioned.fl_str_mv |
2019-05-30T15:46:45Z |
dc.date.available.fl_str_mv |
2019-05-30T15:46:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MARINO, A. P. M. P. et al. CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl. 1, p.93-96, 2005. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/33296 |
dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1590/S0074-02762005000900015 |
dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
identifier_str_mv |
MARINO, A. P. M. P. et al. CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl. 1, p.93-96, 2005. 0074-0276 10.1590/S0074-02762005000900015 1678-8060 |
url |
https://www.arca.fiocruz.br/handle/icict/33296 |
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eng |
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eng |
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openAccess |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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