Quinic acid derivatives inhibit dengue virus replication in vitro
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1186/s12985-015-0443-9 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/22777 |
Resumo: | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. |
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Zanello, Paula RodriguesKoishi, Andrea CristineRezende Júnior, Celso de OliveiraOliveira, Larissa AlbuquerquePereira, Adriane AntoniaAlmeida, Mauro Vieira deSantos, Claudia Nunes Duarte dosBordignon, Juliano2017-10-05T12:29:44Z2017-10-05T12:29:44Z2015ZANELLO, Paula Rodrigues et al. Quinic acid derivatives inhibit dengue virus replication in vitro. Virology Journal, v. 12, n. 223, p. 1-13, 2015.1743-422Xhttps://www.arca.fiocruz.br/handle/icict/2277710.1186/s12985-015-0443-9porBioMed CentralDengueVirus ReplicationAntiviral AgentsQuinic AcidReplicación ViralAntiviralesReplicação ViralAntiviraisÁcido QuínicoQuinic acid derivatives inhibit dengue virus replication in vitroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Dengue is the most prevalent arboviral disease in tropical and sub-tropical areas of the world. The incidence of infection is estimated to be 390 million cases and 25,000 deaths per year. Despite these numbers, neither a specific treatment nor a preventive vaccine is available to protect people living in areas of high risk. With the aim of seeking a treatment that can mitigate dengue infection, we demonstrated that the quinic acid derivatives known as compound 2 and compound 10 were effective against all four dengue virus serotypes and safe for use in a human hepatoma cell line (Huh7.5). Both compounds were non-virucidal to dengue virus particles and did not interfere with early steps of the dengue virus life cycle, including binding and internalization. Experiments using a replicon system demonstrated that compounds 2 and 10 impaired dengue virus replication in Huh7.5 cells. Additionally, the anti-dengue virus effects of the quinic acid derivatives were preserved in human peripheral blood mononuclear cells.Taken together, these data suggest that quinic acid derivatives represent a novel chemical class of active compounds that could be used to combat dengue virus infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/22777/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALZanelloQuinicok.pdfZanelloQuinicok.pdfapplication/pdf3174933https://www.arca.fiocruz.br/bitstream/icict/22777/2/ZanelloQuinicok.pdf1e5b586ed9355c6b930f9eba5723cea5MD52TEXTZanelloQuinicok.pdf.txtZanelloQuinicok.pdf.txtExtracted texttext/plain42751https://www.arca.fiocruz.br/bitstream/icict/22777/3/ZanelloQuinicok.pdf.txtd16a1a5f9b41fc36333f2fef5ecf20b4MD53icict/227772018-08-15 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| dc.title.pt_BR.fl_str_mv |
Quinic acid derivatives inhibit dengue virus replication in vitro |
| title |
Quinic acid derivatives inhibit dengue virus replication in vitro |
| spellingShingle |
Quinic acid derivatives inhibit dengue virus replication in vitro Zanello, Paula Rodrigues Dengue Virus Replication Antiviral Agents Quinic Acid Replicación Viral Antivirales Replicação Viral Antivirais Ácido Quínico |
| title_short |
Quinic acid derivatives inhibit dengue virus replication in vitro |
| title_full |
Quinic acid derivatives inhibit dengue virus replication in vitro |
| title_fullStr |
Quinic acid derivatives inhibit dengue virus replication in vitro |
| title_full_unstemmed |
Quinic acid derivatives inhibit dengue virus replication in vitro |
| title_sort |
Quinic acid derivatives inhibit dengue virus replication in vitro |
| author |
Zanello, Paula Rodrigues |
| author_facet |
Zanello, Paula Rodrigues Koishi, Andrea Cristine Rezende Júnior, Celso de Oliveira Oliveira, Larissa Albuquerque Pereira, Adriane Antonia Almeida, Mauro Vieira de Santos, Claudia Nunes Duarte dos Bordignon, Juliano |
| author_role |
author |
| author2 |
Koishi, Andrea Cristine Rezende Júnior, Celso de Oliveira Oliveira, Larissa Albuquerque Pereira, Adriane Antonia Almeida, Mauro Vieira de Santos, Claudia Nunes Duarte dos Bordignon, Juliano |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Zanello, Paula Rodrigues Koishi, Andrea Cristine Rezende Júnior, Celso de Oliveira Oliveira, Larissa Albuquerque Pereira, Adriane Antonia Almeida, Mauro Vieira de Santos, Claudia Nunes Duarte dos Bordignon, Juliano |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue |
| topic |
Dengue Virus Replication Antiviral Agents Quinic Acid Replicación Viral Antivirales Replicação Viral Antivirais Ácido Quínico |
| dc.subject.en.pt_BR.fl_str_mv |
Virus Replication Antiviral Agents Quinic Acid |
| dc.subject.es.pt_BR.fl_str_mv |
Replicación Viral Antivirales |
| dc.subject.decs.pt_BR.fl_str_mv |
Replicação Viral Antivirais Ácido Quínico |
| description |
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. |
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2015 |
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2015 |
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2017-10-05T12:29:44Z |
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2017-10-05T12:29:44Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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ZANELLO, Paula Rodrigues et al. Quinic acid derivatives inhibit dengue virus replication in vitro. Virology Journal, v. 12, n. 223, p. 1-13, 2015. |
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https://www.arca.fiocruz.br/handle/icict/22777 |
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1743-422X |
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10.1186/s12985-015-0443-9 |
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ZANELLO, Paula Rodrigues et al. Quinic acid derivatives inhibit dengue virus replication in vitro. Virology Journal, v. 12, n. 223, p. 1-13, 2015. 1743-422X 10.1186/s12985-015-0443-9 |
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BioMed Central |
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