Imatinib activity on Schistosoma mansoni.

Detalhes bibliográficos
Autor(a) principal: Katz, Naftale
Data de Publicação: 2013
Outros Autores: Couto, Flávia Fernanda Bubulo, Araújo, Neusa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30689
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil/Academia Mineira de Medicina. Belo Horizonte, MG, Brasil
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spelling Katz, NaftaleCouto, Flávia Fernanda BubuloAraújo, Neusa2018-12-19T11:48:26Z2018-12-19T11:48:26Z2013KATZ, Naftale; COUTO, Flávia Fernanda Bubulo; ARAUJO, Neusa. Imatinib activity on Schistosoma mansoni. Mem. Inst. Oswaldo Cruz, v. 108, n. 7, p. 850-853, 20130074-0276https://www.arca.fiocruz.br/handle/icict/3068910.1590/0074-0276130207engFundação Oswaldo CruzEsquistossomossequimioterapiaimatinibeschistosomiasischemotherapyimatinibImatinib activity on Schistosoma mansoni.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil/Academia Mineira de Medicina. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, BrasilImatinib, a drug used for treatment of human chronic myeloid leukaemia, due to its activity against protein kinases, has been also evaluated in vitro against Schistosoma mansoni showing high schistosomicidal activity. In the present experiments imatinib activity in vitro was confirmed at the doses of 25 µM, 50 µM and 100 µM. The first drug activity observed with the lower dose was interruption of egg-laying and with the higher dosages was the death of the worms. In mice infected with S. mansoni no activity was found even with 1,000 mg/kg/day, 500 mg/kg/day, single oral dose or when administered for three consecutive days. This is another example of the difference of results related to in vitro and in vivo trials using S. mansoni worms.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/30689/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALImatinib activity on Schistosoma mansoni.pdfImatinib activity on Schistosoma mansoni.pdfapplication/pdf3737799https://www.arca.fiocruz.br/bitstream/icict/30689/2/Imatinib%20activity%20on%20Schistosoma%20mansoni.pdf2026a4b57def5ecd323c0f6e54e59aa6MD52TEXTImatinib activity on Schistosoma mansoni.pdf.txtImatinib activity on Schistosoma mansoni.pdf.txtExtracted texttext/plain4https://www.arca.fiocruz.br/bitstream/icict/30689/3/Imatinib%20activity%20on%20Schistosoma%20mansoni.pdf.txtff4c8ff01d544500ea4bfea43e6108c1MD53icict/306892019-06-19 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dc.title.pt_BR.fl_str_mv Imatinib activity on Schistosoma mansoni.
title Imatinib activity on Schistosoma mansoni.
spellingShingle Imatinib activity on Schistosoma mansoni.
Katz, Naftale
Esquistossomosse
quimioterapia
imatinibe
schistosomiasis
chemotherapy
imatinib
title_short Imatinib activity on Schistosoma mansoni.
title_full Imatinib activity on Schistosoma mansoni.
title_fullStr Imatinib activity on Schistosoma mansoni.
title_full_unstemmed Imatinib activity on Schistosoma mansoni.
title_sort Imatinib activity on Schistosoma mansoni.
author Katz, Naftale
author_facet Katz, Naftale
Couto, Flávia Fernanda Bubulo
Araújo, Neusa
author_role author
author2 Couto, Flávia Fernanda Bubulo
Araújo, Neusa
author2_role author
author
dc.contributor.author.fl_str_mv Katz, Naftale
Couto, Flávia Fernanda Bubulo
Araújo, Neusa
dc.subject.other.pt_BR.fl_str_mv Esquistossomosse
quimioterapia
imatinibe
topic Esquistossomosse
quimioterapia
imatinibe
schistosomiasis
chemotherapy
imatinib
dc.subject.en.pt_BR.fl_str_mv schistosomiasis
chemotherapy
imatinib
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil/Academia Mineira de Medicina. Belo Horizonte, MG, Brasil
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2018-12-19T11:48:26Z
dc.date.available.fl_str_mv 2018-12-19T11:48:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv KATZ, Naftale; COUTO, Flávia Fernanda Bubulo; ARAUJO, Neusa. Imatinib activity on Schistosoma mansoni. Mem. Inst. Oswaldo Cruz, v. 108, n. 7, p. 850-853, 2013
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30689
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.eissn.none.fl_str_mv 10.1590/0074-0276130207
identifier_str_mv KATZ, Naftale; COUTO, Flávia Fernanda Bubulo; ARAUJO, Neusa. Imatinib activity on Schistosoma mansoni. Mem. Inst. Oswaldo Cruz, v. 108, n. 7, p. 850-853, 2013
0074-0276
10.1590/0074-0276130207
url https://www.arca.fiocruz.br/handle/icict/30689
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz
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