Evaluation of hydrogen peroxide virucidal efficacy against yellowfever virus 17DD vaccine strain for application in a vaccinemanufacturing industry

Detalhes bibliográficos
Autor(a) principal: Ajório, Ana Carolina Ferreira Ballestê
Data de Publicação: 2021
Outros Autores: Rhodes, Vinícius Pessanha, Rodrigues, Anderson Peclat, Moreira, Filipe Mercês, Diniz, Vanessa Alvaro, Mattoso, Josiane Machado Vieira, Silva, Igor Barbosa da, Guedes Junior, Daniel da Silva, Brandão, Marcelo Luiz Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/53621
Resumo: Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Controle da Qualidade. Rio de Janeiro, RJ, Brasil.
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spelling Ajório, Ana Carolina Ferreira BallestêRhodes, Vinícius PessanhaRodrigues, Anderson PeclatMoreira, Filipe MercêsDiniz, Vanessa AlvaroMattoso, Josiane Machado VieiraSilva, Igor Barbosa daGuedes Junior, Daniel da SilvaBrandão, Marcelo Luiz Lima2022-07-04T12:06:03Z2022-07-04T12:06:03Z2021AJORIO, A. C. F. B. et al. Evaluation of hydrogen peroxide virucidal efficacy against yellow fever virus 17DD vaccine strain for application in a vaccine manufacturing industry. Journal of Pharmaceutical and Biomedical Analysis, v. 204, n. 114264, p. 1-6, 2021.0731-7085https://www.arca.fiocruz.br/handle/icict/5362110.1016/j.jpba.2021.114264engPeróxido de HidrogênioValidação de limpezaVacinaVírus da Febre AmarelaDesinfecçãoInativação de VírusHydrogen peroxideCleaning validationVaccineYellow fever virusDisinfectionVirus inactivationPeróxido de HidrogênioVírus da Febre AmarelaDesinfecçãoInativação de VírusEvaluation of hydrogen peroxide virucidal efficacy against yellowfever virus 17DD vaccine strain for application in a vaccinemanufacturing industryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Controle da Qualidade. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Controle da Qualidade. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Controle da Qualidade. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Controle da Qualidade. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Controle da Qualidade. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Controle da Qualidade. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Controle da Qualidade. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Controle da Qualidade. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Controle da Qualidade. Rio de Janeiro, RJ, Brasil.The aim of this study was to evaluate the inactivation performance of hydrogen peroxide to the yellow fever virus 17DD vaccine strain, used for the production of attenuated yellow fever vaccine, in two matrixes: formulated yellow fever vaccine (FYV) and yellow fever viral suspension - active pharmaceutical ingredient (API). The samples were dried on stainless steel and exposed to hydrogen peroxide liquid (HPL) at concentrations of 30, 10, 3 and 1% for 20 and 60 min; and to hydrogen peroxide vapour (HPV) in an isolator. The exposure to HPL 30 and 10 %, within 20 min, reduced the virus titre at least 3.85 log10 PFU/mL (74.8 %). During 60 min of exposure, the HPL 30, 10 and 3% reduced the virus titre by at least 3.18 log10 PFU/mL (62.6 %). HPV exposure resulted in complete virus inactivation in FYV (≥ 4.42 log10 PFU/mL reduction) and for API samples 3.17 log10 PFU/mL (64.3 %) reduction. Hydrogen peroxide showed to be a promising disinfectant for elimination of yellow fever virus. However, the optimum concentration and contact time will vary depending on the type of application, and as such may complement individual risk assessments of biological production processes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83105https://www.arca.fiocruz.br/bitstream/icict/53621/1/license.txt612d7ba06cfe248f84ebe951752a8a5aMD51ORIGINALAjorio et al 2021.pdfAjorio et al 2021.pdfapplication/pdf684072https://www.arca.fiocruz.br/bitstream/icict/53621/2/Ajorio%20et%20al%202021.pdf1d6efbe778cdc6223a7c2a98bfb44f1cMD52icict/536212022-07-12 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dc.title.pt_BR.fl_str_mv Evaluation of hydrogen peroxide virucidal efficacy against yellowfever virus 17DD vaccine strain for application in a vaccinemanufacturing industry
title Evaluation of hydrogen peroxide virucidal efficacy against yellowfever virus 17DD vaccine strain for application in a vaccinemanufacturing industry
spellingShingle Evaluation of hydrogen peroxide virucidal efficacy against yellowfever virus 17DD vaccine strain for application in a vaccinemanufacturing industry
Ajório, Ana Carolina Ferreira Ballestê
Peróxido de Hidrogênio
Validação de limpeza
Vacina
Vírus da Febre Amarela
Desinfecção
Inativação de Vírus
Hydrogen peroxide
Cleaning validation
Vaccine
Yellow fever virus
Disinfection
Virus inactivation
Peróxido de Hidrogênio
Vírus da Febre Amarela
Desinfecção
Inativação de Vírus
title_short Evaluation of hydrogen peroxide virucidal efficacy against yellowfever virus 17DD vaccine strain for application in a vaccinemanufacturing industry
title_full Evaluation of hydrogen peroxide virucidal efficacy against yellowfever virus 17DD vaccine strain for application in a vaccinemanufacturing industry
title_fullStr Evaluation of hydrogen peroxide virucidal efficacy against yellowfever virus 17DD vaccine strain for application in a vaccinemanufacturing industry
title_full_unstemmed Evaluation of hydrogen peroxide virucidal efficacy against yellowfever virus 17DD vaccine strain for application in a vaccinemanufacturing industry
title_sort Evaluation of hydrogen peroxide virucidal efficacy against yellowfever virus 17DD vaccine strain for application in a vaccinemanufacturing industry
author Ajório, Ana Carolina Ferreira Ballestê
author_facet Ajório, Ana Carolina Ferreira Ballestê
Rhodes, Vinícius Pessanha
Rodrigues, Anderson Peclat
Moreira, Filipe Mercês
Diniz, Vanessa Alvaro
Mattoso, Josiane Machado Vieira
Silva, Igor Barbosa da
Guedes Junior, Daniel da Silva
Brandão, Marcelo Luiz Lima
author_role author
author2 Rhodes, Vinícius Pessanha
Rodrigues, Anderson Peclat
Moreira, Filipe Mercês
Diniz, Vanessa Alvaro
Mattoso, Josiane Machado Vieira
Silva, Igor Barbosa da
Guedes Junior, Daniel da Silva
Brandão, Marcelo Luiz Lima
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ajório, Ana Carolina Ferreira Ballestê
Rhodes, Vinícius Pessanha
Rodrigues, Anderson Peclat
Moreira, Filipe Mercês
Diniz, Vanessa Alvaro
Mattoso, Josiane Machado Vieira
Silva, Igor Barbosa da
Guedes Junior, Daniel da Silva
Brandão, Marcelo Luiz Lima
dc.subject.other.pt_BR.fl_str_mv Peróxido de Hidrogênio
Validação de limpeza
Vacina
Vírus da Febre Amarela
Desinfecção
Inativação de Vírus
topic Peróxido de Hidrogênio
Validação de limpeza
Vacina
Vírus da Febre Amarela
Desinfecção
Inativação de Vírus
Hydrogen peroxide
Cleaning validation
Vaccine
Yellow fever virus
Disinfection
Virus inactivation
Peróxido de Hidrogênio
Vírus da Febre Amarela
Desinfecção
Inativação de Vírus
dc.subject.en.pt_BR.fl_str_mv Hydrogen peroxide
Cleaning validation
Vaccine
Yellow fever virus
Disinfection
Virus inactivation
dc.subject.decs.pt_BR.fl_str_mv Peróxido de Hidrogênio
Vírus da Febre Amarela
Desinfecção
Inativação de Vírus
description Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Controle da Qualidade. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-07-04T12:06:03Z
dc.date.available.fl_str_mv 2022-07-04T12:06:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv AJORIO, A. C. F. B. et al. Evaluation of hydrogen peroxide virucidal efficacy against yellow fever virus 17DD vaccine strain for application in a vaccine manufacturing industry. Journal of Pharmaceutical and Biomedical Analysis, v. 204, n. 114264, p. 1-6, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/53621
dc.identifier.issn.pt_BR.fl_str_mv 0731-7085
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/j.jpba.2021.114264
identifier_str_mv AJORIO, A. C. F. B. et al. Evaluation of hydrogen peroxide virucidal efficacy against yellow fever virus 17DD vaccine strain for application in a vaccine manufacturing industry. Journal of Pharmaceutical and Biomedical Analysis, v. 204, n. 114264, p. 1-6, 2021.
0731-7085
10.1016/j.jpba.2021.114264
url https://www.arca.fiocruz.br/handle/icict/53621
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/53621/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/53621/2/Ajorio%20et%20al%202021.pdf
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