Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries

Jaenisch, Thomas; Tam, Dong Thi Hoai; Kieu, Nguyen Tan Thanh; Van Ngoc, Tran; Nam, Nguyen Tran; Van Kinh, Nguyen; Yacoub, Sophie; Chanpheaktra, Ngoun; Kumar, Varun; See, Lucy Lum Chai; Sathar, Jameela; Sandoval, Ernesto Pleités; Alfaro, Gabriela Maria Marón; Laksono, Ida Safitri; Mahendradhata, Yodi; Sarker, Malabika; Ahmed, Firoz; Caprara, Andrea; Benevides, Bruno Souza; Marques, Ernesto T. A.; Magalhaes, Tereza; Brasil, Patricia; Netto, Marco; Tami, Adriana; Bethencourt, Sarah E.; Guzman, Maria; Simmons, Cameron; Quyen, Nguyen Thanh Ha; Merson, Laura; Dung, Nguyen Thi Phuong; Beck, Dorothea; Wirths, Marius; Wolbers, Marcel; Lam, Phung Khanh; Rosenberger, Kerstin; Wills, Bridget

Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries

Detalhes bibliográficos
Autor(a) principal:	Jaenisch, Thomas
Data de Publicação:	2016
Outros Autores:	Tam, Dong Thi Hoai, Kieu, Nguyen Tan Thanh, Van Ngoc, Tran, Nam, Nguyen Tran, Van Kinh, Nguyen, Yacoub, Sophie, Chanpheaktra, Ngoun, Kumar, Varun, See, Lucy Lum Chai, Sathar, Jameela, Sandoval, Ernesto Pleités, Alfaro, Gabriela Maria Marón, Laksono, Ida Safitri, Mahendradhata, Yodi, Sarker, Malabika, Ahmed, Firoz, Caprara, Andrea, Benevides, Bruno Souza, Marques, Ernesto T. A., Magalhaes, Tereza, Brasil, Patricia, Netto, Marco, Tami, Adriana, Bethencourt, Sarah E., Guzman, Maria, Simmons, Cameron, Quyen, Nguyen Thanh Ha, Merson, Laura, Dung, Nguyen Thi Phuong, Beck, Dorothea, Wirths, Marius, Wolbers, Marcel, Lam, Phung Khanh, Rosenberger, Kerstin, Wills, Bridget
Tipo de documento:	Artigo
Idioma:	por
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/20884
Resumo:	Patrícia Brasil - Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.

Metadados do item

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network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
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spelling	Jaenisch, ThomasTam, Dong Thi HoaiKieu, Nguyen Tan ThanhVan Ngoc, TranNam, Nguyen TranVan Kinh, NguyenYacoub, SophieChanpheaktra, NgounKumar, VarunSee, Lucy Lum ChaiSathar, JameelaSandoval, Ernesto PleitésAlfaro, Gabriela Maria MarónLaksono, Ida SafitriMahendradhata, YodiSarker, MalabikaAhmed, FirozCaprara, AndreaBenevides, Bruno SouzaMarques, Ernesto T. A.Magalhaes, TerezaBrasil, PatriciaNetto, MarcoTami, AdrianaBethencourt, Sarah E.Guzman, MariaSimmons, CameronQuyen, Nguyen Thanh HaMerson, LauraDung, Nguyen Thi PhuongBeck, DorotheaWirths, MariusWolbers, MarcelLam, Phung KhanhRosenberger, KerstinWills, Bridget2017-08-31T19:06:38Z2017-08-31T19:06:38Z2016JAENISCH, T. et al. Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries. BMC infectious diseases, v. 16, p. 1-11, Mar. 20161471-2334https://www.arca.fiocruz.br/handle/icict/2088410.1186/s12879-016-1440-3Patrícia Brasil - Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.Ernesto T. A. Marques e Tereza Magalhães - Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.1Section Clinical Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany. 2Oxford University Clinical Research Unit, 764 Vo Van Kiet Street, District 5, Ho Chi Minh City, Vietnam. 3University of Medicine and Pharmacy of Ho Chi Minh City, Ho Chi Minh City, Vietnam. 4Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. 5Children’s Hospital Number 2,Ho Chi Minh City, Vietnam. 6National Hospital for Tropical Diseases, Hanoi, Vietnam. 7Department of Medicine, Imperial College, London, UK. 8 Angkor Hospital for Children, Siem Reap, Cambodia. 9University of Malaya Medical Centre, Kuala Lumpur, Malaysia. 10Ampang Hospital, Kuala umpur, Malaysia 11Hospital Nacional de Niños Benjamin Bloom, San Salvador, El Salvador. 12Gadjah Mada University, Yogyakarta, Indonesia. 13James P Grant School of Public Health, BRAC University, Dhaka, Bangladesh. 14International Center for Diarrhoeal Diseases Research, Dhaka, Bangladesh. 15Universidade Estadual Do Ceará, Fortaleza, Brazil. 16Centro de Pesquisas Aggeu Magalhaes, Fundacao Oswaldo Cruz, Recife, Pernambuco, Brazil. 17Instituto Nacional de Infectologia Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil. 18Secretaria Municipal de Saúde de Resende, Rio de Janeiro, Brazil. 19Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 20Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Venezuela. 21Institute Pedro Kouri, Havana, Cuba. 22Department of Microbiology and Immunology, The Peter Doherty Institute, University of Melbourne, Melbourne, Australia. 23Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK. 24Present address: Rwanda ilitary Hospital and the University of Rwanda in Kigali, Kigali, Rwanda. 25Present address: St. Jude Children’s Research Hospital, Memphis, TN, USA.Múltipla - Ver em Notas.Background: The burden of dengue continues to increase globally, with an estimated 100 million clinically apparent infections occurring each year. Although most dengue infections are asymptomatic, patients can present with a wide spectrum of clinical symptoms ranging from mild febrile illness through to severe manifestations of bleeding, organ impairment, and hypovolaemic shock due to a systemic vascular leak syndrome. Clinical diagnosis of dengue and identification of which patients are likely to develop severe disease remain challenging. This study aims to improve diagnosis and clinical management through approaches designed a) to differentiate between dengue and other common febrile illness within 72 h of fever onset, and b) among patients with dengue to identify markers that are predictive of the likelihood of evolving to a more severe disease course. Method/Design: This is a prospective multi-centre observational study aiming to enrol 7–8000 participants aged ≥5 years presenting with a febrile illness consistent with dengue to outpatient health facilities in 8 countries across Asia and Latin America. Patients presenting within 72 h of fever onset who do not exhibit signs of severe disease are eligible for the study. A broad range of clinical and laboratory parameters are assessed daily for up to 6 days during the acute illness, and also at a follow up visit 1 week later. Discussion: Data from this large cohort of patients, enrolled early with undifferentiated fever, will be used to develop a practical diagnostic algorithm and a robust clinical case definition for dengue. Additionally, among patients with confirmed dengue we aim to identify simple clinical and laboratory parameters associated with progression to a more severe disease course. We will also investigate early virological and serological correlates of severe disease, and examine genetic associations in this large heterogeneous cohort. In addition the results will be used to assess the new World Health Organization classification scheme for dengue in practice, and to update the guidelines for “Integrated Management of Childhood Illness” used in dengue-endemic countries.porDengueVírus da DengueAdolescentAdultAsiaChildDengueDengue VirusDiagnosisDiagnosis, DifferentialDisease ManagementFemaleHumansLatin AmericaMaleMiddle AgedPathogenesisProspective StudiesRisk FactorsRisk predictionYoung AdultVírus da DengueDengueDiagnóstico DiferencialGerenciamento ClínicoFemininoHumanosAmérica LatinaMasculinoMeia-IdadePatogênese HomeopáticaEstudos ProspectivosFatores de riscoClinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countriesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv	Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries
title	Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries
spellingShingle	Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries Jaenisch, Thomas Dengue Vírus da Dengue Adolescent Adult Asia Child Dengue Dengue Virus Diagnosis Diagnosis, Differential Disease Management Female Humans Latin America Male Middle Aged Pathogenesis Prospective Studies Risk Factors Risk prediction Young Adult Vírus da Dengue Dengue Diagnóstico Diferencial Gerenciamento Clínico Feminino Humanos América Latina Masculino Meia-Idade Patogênese Homeopática Estudos Prospectivos Fatores de risco
title_short	Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries
title_full	Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries
title_fullStr	Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries
title_full_unstemmed	Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries
title_sort	Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries
author	Jaenisch, Thomas
author_facet	Jaenisch, Thomas Tam, Dong Thi Hoai Kieu, Nguyen Tan Thanh Van Ngoc, Tran Nam, Nguyen Tran Van Kinh, Nguyen Yacoub, Sophie Chanpheaktra, Ngoun Kumar, Varun See, Lucy Lum Chai Sathar, Jameela Sandoval, Ernesto Pleités Alfaro, Gabriela Maria Marón Laksono, Ida Safitri Mahendradhata, Yodi Sarker, Malabika Ahmed, Firoz Caprara, Andrea Benevides, Bruno Souza Marques, Ernesto T. A. Magalhaes, Tereza Brasil, Patricia Netto, Marco Tami, Adriana Bethencourt, Sarah E. Guzman, Maria Simmons, Cameron Quyen, Nguyen Thanh Ha Merson, Laura Dung, Nguyen Thi Phuong Beck, Dorothea Wirths, Marius Wolbers, Marcel Lam, Phung Khanh Rosenberger, Kerstin Wills, Bridget
author_role	author
author2	Tam, Dong Thi Hoai Kieu, Nguyen Tan Thanh Van Ngoc, Tran Nam, Nguyen Tran Van Kinh, Nguyen Yacoub, Sophie Chanpheaktra, Ngoun Kumar, Varun See, Lucy Lum Chai Sathar, Jameela Sandoval, Ernesto Pleités Alfaro, Gabriela Maria Marón Laksono, Ida Safitri Mahendradhata, Yodi Sarker, Malabika Ahmed, Firoz Caprara, Andrea Benevides, Bruno Souza Marques, Ernesto T. A. Magalhaes, Tereza Brasil, Patricia Netto, Marco Tami, Adriana Bethencourt, Sarah E. Guzman, Maria Simmons, Cameron Quyen, Nguyen Thanh Ha Merson, Laura Dung, Nguyen Thi Phuong Beck, Dorothea Wirths, Marius Wolbers, Marcel Lam, Phung Khanh Rosenberger, Kerstin Wills, Bridget
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Jaenisch, Thomas Tam, Dong Thi Hoai Kieu, Nguyen Tan Thanh Van Ngoc, Tran Nam, Nguyen Tran Van Kinh, Nguyen Yacoub, Sophie Chanpheaktra, Ngoun Kumar, Varun See, Lucy Lum Chai Sathar, Jameela Sandoval, Ernesto Pleités Alfaro, Gabriela Maria Marón Laksono, Ida Safitri Mahendradhata, Yodi Sarker, Malabika Ahmed, Firoz Caprara, Andrea Benevides, Bruno Souza Marques, Ernesto T. A. Magalhaes, Tereza Brasil, Patricia Netto, Marco Tami, Adriana Bethencourt, Sarah E. Guzman, Maria Simmons, Cameron Quyen, Nguyen Thanh Ha Merson, Laura Dung, Nguyen Thi Phuong Beck, Dorothea Wirths, Marius Wolbers, Marcel Lam, Phung Khanh Rosenberger, Kerstin Wills, Bridget
dc.subject.other.pt_BR.fl_str_mv	Dengue Vírus da Dengue
topic	Dengue Vírus da Dengue Adolescent Adult Asia Child Dengue Dengue Virus Diagnosis Diagnosis, Differential Disease Management Female Humans Latin America Male Middle Aged Pathogenesis Prospective Studies Risk Factors Risk prediction Young Adult Vírus da Dengue Dengue Diagnóstico Diferencial Gerenciamento Clínico Feminino Humanos América Latina Masculino Meia-Idade Patogênese Homeopática Estudos Prospectivos Fatores de risco
dc.subject.en.pt_BR.fl_str_mv	Adolescent Adult Asia Child Dengue Dengue Virus Diagnosis Diagnosis, Differential Disease Management Female Humans Latin America Male Middle Aged Pathogenesis Prospective Studies Risk Factors Risk prediction Young Adult
dc.subject.decs.pt_BR.fl_str_mv	Vírus da Dengue Dengue Diagnóstico Diferencial Gerenciamento Clínico Feminino Humanos América Latina Masculino Meia-Idade Patogênese Homeopática Estudos Prospectivos Fatores de risco
description	Patrícia Brasil - Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.
publishDate	2016
dc.date.issued.fl_str_mv	2016
dc.date.accessioned.fl_str_mv	2017-08-31T19:06:38Z
dc.date.available.fl_str_mv	2017-08-31T19:06:38Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	JAENISCH, T. et al. Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries. BMC infectious diseases, v. 16, p. 1-11, Mar. 2016
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/20884
dc.identifier.issn.pt_BR.fl_str_mv	1471-2334
dc.identifier.doi.pt_BR.fl_str_mv	10.1186/s12879-016-1440-3
identifier_str_mv	JAENISCH, T. et al. Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries. BMC infectious diseases, v. 16, p. 1-11, Mar. 2016 1471-2334 10.1186/s12879-016-1440-3
url	https://www.arca.fiocruz.br/handle/icict/20884
dc.language.iso.fl_str_mv	por
language	por
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/20884/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/20884/2/26968374%202016%20jae-cli.oa.pdf https://www.arca.fiocruz.br/bitstream/icict/20884/3/26968374%202016%20jae-cli.oa.pdf.txt
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries

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