Lessons Learned from Implementation of an Interferon Gamma Release Assay to Screen for Latent Tuberculosis Infection in a Large Multicenter Observational Cohort Study in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1128/Spectrum.01163-21 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50478 |
Resumo: | Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil / Universidade Federal do Amazonas. Escola de Enfermagem de Manaus. Manaus, AM, Brasil / Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brasil. |
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Costa, Allyson G.Carvalho, Brenda K. S.Araújo-Pereira, MarianaIbiapina, Hiochelson N. S.Spener-Gomes, RenataSouza, Alexandra B.Gomes-Silva, AdrianoAndrade, Alice M. S.Silva, Elisangela C.Arriaga, María B.Benjamin, AlineRocha, Michael S.Moreira, Adriana S. R.Oliveira, Jamile G.Figueiredo, Marina C.Turner, Megan M.Durovni, BetinaCavalcante, SolangeKritski, Afranio L.Rolla, Valeria C.Sterling, Timothy R.Andrade, Bruno B.Cordeiro-Santos, MarceloRePORT-Brazil Consortium2021-12-17T16:29:52Z2021-12-17T16:29:52Z2021COSTA, Allyson G. et al. Lessons Learned from Implementation of an Interferon Gamma Release Assay to Screen for Latent Tuberculosis Infection in a Large Multicenter Observational Cohort Study in Brazil. Microbiology spectrum, v. 9, n. 3, p. 1-12, 20212165-0497https://www.arca.fiocruz.br/handle/icict/5047810.1128/Spectrum.01163-21engAmerican Society for MicrobiologyLessons Learned from Implementation of an Interferon Gamma Release Assay to Screen for Latent Tuberculosis Infection in a Large Multicenter Observational Cohort Study in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil / Universidade Federal do Amazonas. Escola de Enfermagem de Manaus. Manaus, AM, Brasil / Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brasil.Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil.Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil.Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil.Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil / Universidade Estadual do Norte Fluminense Darcy Ribeiro. Centro de Biociências e Biotecnologia. Rio de Janeiro, RJ, Brasil / Secretaria Estadual de Saúde do Estado do Rio d Janeiro. Fundação Saúde do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil.Secretaria Municipal de Saúde do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Vanderbilt University School of Medicine. Division of Infectious Diseases, Department of Medicine. Nashville, Tennessee, USA.Vanderbilt University School of Medicine. Division of Infectious Diseases, Department of Medicine. Nashville, Tennessee, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Secretaria Municipal de Saúde do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Secretaria Municipal de Saúde do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Vanderbilt University School of Medicine. Division of Infectious Diseases, Department of Medicine. Nashville, Tennessee, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil.Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil / Universidade Nilton Lins. Faculdade de Medicina. Manaus, AM, Brasil.The interferon gamma release assay (IGRA) has emerged as a useful tool for identifying latent tuberculosis infection (LTBI). This assay can be performed through testing platforms such as the QuantiFERON-TB Gold Plus (QFT-Plus) assay. This in vitro test has been incorporated into several guidelines worldwide and has recently been considered by the World Health Organization (WHO) for the diagnosis of LTBI. The possibility of systematically implementing IGRAs such as the QFT-Plus assay in centers that perform LTBI screening has been accelerated by the decreased availability of the tuberculin skin test (TST) in several countries. Nevertheless, the process to implement IGRA testing in routine clinical care has many gaps. The study utilized the expertise acquired by the laboratory teams of the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil consortium during study protocol implementation of LTBI screening of tuberculosis (TB) close contacts. RePORT-Brazil includes clinical research sites from Brazilian cities and is the largest multicenter cohort of TB close contacts in the country to date. Operational and logistical challenges faced during IGRA implementation in all study laboratories are described, as well as the solutions that were developed and led to the successful establishment of IGRA testing in RePORT-Brazil. The descriptions of the problems identified and resolved in this study can assist laboratories implementing IGRAs, in addition to manufacturers of IGRAs providing effective technical support. This will facilitate the implementation of IGRA testing in countries with large TB burdens, such as Brazil. IMPORTANCE The IGRA has emerged as a useful tool for identifying persons with LTBI. Although the implementation of IGRAs is of utmost importance, to our knowledge there is scarce information on the identification of logistical and technical challenges for systematic screening for LTBI on a large scale. Thus, the descriptions of the problems identified and resolved in this study can assist laboratories implementing IGRAs, in addition to manufacturers of IGRAs providing effective technical support. This will facilitate the implementation of IGRA testing in countries with large TB burdens, such as Brazil.IGRALTBIQuantiFERON-PlusQuality controlScreeningTuberculosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/50478/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALLessons_Adriano_Silva_etal_INI_2021.pdfLessons_Adriano_Silva_etal_INI_2021.pdfapplication/pdf2188316https://www.arca.fiocruz.br/bitstream/icict/50478/2/Lessons_Adriano_Silva_etal_INI_2021.pdfef7c99a1726af040b42dae16bfd1d6edMD52icict/504782021-12-17 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| dc.title.pt_BR.fl_str_mv |
Lessons Learned from Implementation of an Interferon Gamma Release Assay to Screen for Latent Tuberculosis Infection in a Large Multicenter Observational Cohort Study in Brazil |
| title |
Lessons Learned from Implementation of an Interferon Gamma Release Assay to Screen for Latent Tuberculosis Infection in a Large Multicenter Observational Cohort Study in Brazil |
| spellingShingle |
Lessons Learned from Implementation of an Interferon Gamma Release Assay to Screen for Latent Tuberculosis Infection in a Large Multicenter Observational Cohort Study in Brazil Costa, Allyson G. IGRA LTBI QuantiFERON-Plus Quality control Screening Tuberculosis |
| title_short |
Lessons Learned from Implementation of an Interferon Gamma Release Assay to Screen for Latent Tuberculosis Infection in a Large Multicenter Observational Cohort Study in Brazil |
| title_full |
Lessons Learned from Implementation of an Interferon Gamma Release Assay to Screen for Latent Tuberculosis Infection in a Large Multicenter Observational Cohort Study in Brazil |
| title_fullStr |
Lessons Learned from Implementation of an Interferon Gamma Release Assay to Screen for Latent Tuberculosis Infection in a Large Multicenter Observational Cohort Study in Brazil |
| title_full_unstemmed |
Lessons Learned from Implementation of an Interferon Gamma Release Assay to Screen for Latent Tuberculosis Infection in a Large Multicenter Observational Cohort Study in Brazil |
| title_sort |
Lessons Learned from Implementation of an Interferon Gamma Release Assay to Screen for Latent Tuberculosis Infection in a Large Multicenter Observational Cohort Study in Brazil |
| author |
Costa, Allyson G. |
| author_facet |
Costa, Allyson G. Carvalho, Brenda K. S. Araújo-Pereira, Mariana Ibiapina, Hiochelson N. S. Spener-Gomes, Renata Souza, Alexandra B. Gomes-Silva, Adriano Andrade, Alice M. S. Silva, Elisangela C. Arriaga, María B. Benjamin, Aline Rocha, Michael S. Moreira, Adriana S. R. Oliveira, Jamile G. Figueiredo, Marina C. Turner, Megan M. Durovni, Betina Cavalcante, Solange Kritski, Afranio L. Rolla, Valeria C. Sterling, Timothy R. Andrade, Bruno B. Cordeiro-Santos, Marcelo RePORT-Brazil Consortium |
| author_role |
author |
| author2 |
Carvalho, Brenda K. S. Araújo-Pereira, Mariana Ibiapina, Hiochelson N. S. Spener-Gomes, Renata Souza, Alexandra B. Gomes-Silva, Adriano Andrade, Alice M. S. Silva, Elisangela C. Arriaga, María B. Benjamin, Aline Rocha, Michael S. Moreira, Adriana S. R. Oliveira, Jamile G. Figueiredo, Marina C. Turner, Megan M. Durovni, Betina Cavalcante, Solange Kritski, Afranio L. Rolla, Valeria C. Sterling, Timothy R. Andrade, Bruno B. Cordeiro-Santos, Marcelo RePORT-Brazil Consortium |
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author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Costa, Allyson G. Carvalho, Brenda K. S. Araújo-Pereira, Mariana Ibiapina, Hiochelson N. S. Spener-Gomes, Renata Souza, Alexandra B. Gomes-Silva, Adriano Andrade, Alice M. S. Silva, Elisangela C. Arriaga, María B. Benjamin, Aline Rocha, Michael S. Moreira, Adriana S. R. Oliveira, Jamile G. Figueiredo, Marina C. Turner, Megan M. Durovni, Betina Cavalcante, Solange Kritski, Afranio L. Rolla, Valeria C. Sterling, Timothy R. Andrade, Bruno B. Cordeiro-Santos, Marcelo RePORT-Brazil Consortium |
| dc.subject.en.pt_BR.fl_str_mv |
IGRA LTBI QuantiFERON-Plus Quality control Screening Tuberculosis |
| topic |
IGRA LTBI QuantiFERON-Plus Quality control Screening Tuberculosis |
| description |
Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil / Universidade Federal do Amazonas. Escola de Enfermagem de Manaus. Manaus, AM, Brasil / Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brasil. |
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2021 |
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2021-12-17T16:29:52Z |
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2021-12-17T16:29:52Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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COSTA, Allyson G. et al. Lessons Learned from Implementation of an Interferon Gamma Release Assay to Screen for Latent Tuberculosis Infection in a Large Multicenter Observational Cohort Study in Brazil. Microbiology spectrum, v. 9, n. 3, p. 1-12, 2021 |
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https://www.arca.fiocruz.br/handle/icict/50478 |
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2165-0497 |
| dc.identifier.doi.none.fl_str_mv |
10.1128/Spectrum.01163-21 |
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COSTA, Allyson G. et al. Lessons Learned from Implementation of an Interferon Gamma Release Assay to Screen for Latent Tuberculosis Infection in a Large Multicenter Observational Cohort Study in Brazil. Microbiology spectrum, v. 9, n. 3, p. 1-12, 2021 2165-0497 10.1128/Spectrum.01163-21 |
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American Society for Microbiology |
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American Society for Microbiology |
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| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1822791751563214848 |