Macrophage Polarization in Chagas Disease

Detalhes bibliográficos
Autor(a) principal: Zanluqui, Nagela Ghabdan
Data de Publicação: 2015
Outros Autores: Wowk, Pryscila Fanini, Pinge-Filho, Phileno
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15543
Resumo: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
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spelling Zanluqui, Nagela GhabdanWowk, Pryscila FaniniPinge-Filho, Phileno2016-08-30T16:22:50Z2016-08-30T16:22:50Z2015ZANLUQUI, Nagela Ghabdan; WOWK, Pryscilla Fanini; PINGE-FILHO, Phileno. Macrophage polarization in Chagas Disease. Journal of Clinical & Cellular Immunology, v. 6, n. 2, p. 1-6, 2015.2155-9899https://www.arca.fiocruz.br/handle/icict/1554310.4172/2155-9899.1000317porMacrophage Polarization in Chagas Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brasil.Macrophages are terminally differentiated cells of the mononuclear phagocytic system, which play an indispensable role in the maintenance of homeostasis and defense. Macrophages can be phenotypically polarized by the microenvironment to mount specific functional responses. Polarized macrophages can be broadly classified into two main groups: classically activated macrophages (M1), whose prototypical activating stimuli are IFN-γ and LPS, and alternatively activated macrophages (M2), further subdivided in M2a (after exposure to IL-4 or IL-13), M2b (immune complexes in combination with IL-1β or LPS) and M2c (IL-10, TGF-β or glucocorticoids). M1 exhibit potent microbicidal properties and promote strong IL-12-mediated Th1 responses, while M2 macrophages support Th2- associated effector functions. Here we review the main functions of polarized macrophages in Chagas disease and discuss their potential value in evaluating disease severity.Macrophage polarizationTrypanosoma cruziTherapiesMacrófagosTerapêuticainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15543/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmacrophage-polarization-in-chagas-disease-2155-9899-1000317.pdfmacrophage-polarization-in-chagas-disease-2155-9899-1000317.pdfapplication/pdf660126https://www.arca.fiocruz.br/bitstream/icict/15543/2/macrophage-polarization-in-chagas-disease-2155-9899-1000317.pdf4da541af34b392da2847a7ef5bd1082aMD52TEXTmacrophage-polarization-in-chagas-disease-2155-9899-1000317.pdf.txtmacrophage-polarization-in-chagas-disease-2155-9899-1000317.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Macrophage Polarization in Chagas Disease
title Macrophage Polarization in Chagas Disease
spellingShingle Macrophage Polarization in Chagas Disease
Zanluqui, Nagela Ghabdan
Macrophage polarization
Trypanosoma cruzi
Therapies
Macrófagos
Terapêutica
title_short Macrophage Polarization in Chagas Disease
title_full Macrophage Polarization in Chagas Disease
title_fullStr Macrophage Polarization in Chagas Disease
title_full_unstemmed Macrophage Polarization in Chagas Disease
title_sort Macrophage Polarization in Chagas Disease
author Zanluqui, Nagela Ghabdan
author_facet Zanluqui, Nagela Ghabdan
Wowk, Pryscila Fanini
Pinge-Filho, Phileno
author_role author
author2 Wowk, Pryscila Fanini
Pinge-Filho, Phileno
author2_role author
author
dc.contributor.author.fl_str_mv Zanluqui, Nagela Ghabdan
Wowk, Pryscila Fanini
Pinge-Filho, Phileno
dc.subject.en.pt_BR.fl_str_mv Macrophage polarization
Trypanosoma cruzi
Therapies
topic Macrophage polarization
Trypanosoma cruzi
Therapies
Macrófagos
Terapêutica
dc.subject.decs.pt_BR.fl_str_mv Macrófagos
Terapêutica
description Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-08-30T16:22:50Z
dc.date.available.fl_str_mv 2016-08-30T16:22:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv ZANLUQUI, Nagela Ghabdan; WOWK, Pryscilla Fanini; PINGE-FILHO, Phileno. Macrophage polarization in Chagas Disease. Journal of Clinical & Cellular Immunology, v. 6, n. 2, p. 1-6, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15543
dc.identifier.issn.pt_BR.fl_str_mv 2155-9899
dc.identifier.doi.pt_BR.fl_str_mv 10.4172/2155-9899.1000317
identifier_str_mv ZANLUQUI, Nagela Ghabdan; WOWK, Pryscilla Fanini; PINGE-FILHO, Phileno. Macrophage polarization in Chagas Disease. Journal of Clinical & Cellular Immunology, v. 6, n. 2, p. 1-6, 2015.
2155-9899
10.4172/2155-9899.1000317
url https://www.arca.fiocruz.br/handle/icict/15543
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