Use of Environmental Enrichment as a Clinical Methodology During Acute Experimental Infection by Trypanosoma Cruzi

Detalhes bibliográficos
Autor(a) principal: Sousa, Maria Carolina da Silva
Data de Publicação: 2021
Outros Autores: Rossi, Maria Inês Doria, Evagelista, Alexandre Andrade, Oliveira, Gabriel Melo de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48426
Resumo: Fundação Oswaldo Cruz. Instituto de Ciência e Tecnologia em Biomodelos. Rio de Janeiro, RJ, Brasil.
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spelling Sousa, Maria Carolina da SilvaRossi, Maria Inês DoriaEvagelista, Alexandre AndradeOliveira, Gabriel Melo de2021-07-30T14:29:28Z2021-07-30T14:29:28Z2021SOUSA, Maria Carolina da Silva et al. Use of Environmental Enrichment as a Clinical Methodology During Acute Experimental Infection by Trypanosoma Cruzi. American Journal of Biomedical Research, v. 13, n. 4, 8 p, July 2021.2642-1747https://www.arca.fiocruz.br/handle/icict/4842610.34297/AJBSR.2021.13.001886engBiomedical ScienceRatoBem estar animalParâmetros não invasivosEnriquecimento AmbientalMouseAnimal welfareNon invasive ParametersEnvironmental EnrichmentUse of Environmental Enrichment as a Clinical Methodology During Acute Experimental Infection by Trypanosoma Cruziinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Ciência e Tecnologia em Biomodelos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Ciência e Tecnologia em Biomodelos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.One critial point in the Laboratory Animal Science (CAL) is the non-invasive evaluation of Animal Welfare (BEA). The detection (predictive or diagnostic) of the presence of suffering in mice when used for scientific purposes is a gap. The manuscrip aim to create a technical-scientific form to preditive presence of suffering in mice lab, based on the principle of Refinement of the 3Rs and BEA monitoring. Our methodology was based in usual environmental enrichment the objects, the trapeze. From these observations, our study hypothesis emerged, which was, the creation of the #1 Trap prototype and the measurement through the daily counting of the number of trapeze use during 15 minutes. Experimental acute infection by Trypanosoma cruzi was experimental model in Swiss Webster mice. Our results described that, after division into four groups: [N] without infection and [Inf] mice infected and without treatment. The predictive statistical difference was observed on the 11th day post infection (dpi) when compared ([N]: 72±18.5 Events number/15min) and ([Inf]: 32±13.1 Events number/15min) (p ≤ 0.05). The 21st dpi was the most severe time point ([N]: 75±17.3 and [Inf]: 11±5.1 Events number/15min, respectively) (p ≤ 0.05). So, our results suggest the #1 Trap prototype has predictive and monitoring capacity for experimental disease course. It makes it possible to prevent suffering and preservation of mice welfare during acute T. cruzi experimental model.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/48426/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGabrielOliveira_Alexandrevagelista_etal_IOC_2021.pdfGabrielOliveira_Alexandrevagelista_etal_IOC_2021.pdfapplication/pdf618435https://www.arca.fiocruz.br/bitstream/icict/48426/2/GabrielOliveira_Alexandrevagelista_etal_IOC_2021.pdf0b2d9e151b03671102141a77af728e50MD52TEXTGabrielOliveira_Alexandrevagelista_etal_IOC_2021.pdf.txtGabrielOliveira_Alexandrevagelista_etal_IOC_2021.pdf.txtExtracted texttext/plain33537https://www.arca.fiocruz.br/bitstream/icict/48426/3/GabrielOliveira_Alexandrevagelista_etal_IOC_2021.pdf.txt19f1d5d7707aa8d428689ff80e880c0dMD53icict/484262021-07-31 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dc.title.pt_BR.fl_str_mv Use of Environmental Enrichment as a Clinical Methodology During Acute Experimental Infection by Trypanosoma Cruzi
title Use of Environmental Enrichment as a Clinical Methodology During Acute Experimental Infection by Trypanosoma Cruzi
spellingShingle Use of Environmental Enrichment as a Clinical Methodology During Acute Experimental Infection by Trypanosoma Cruzi
Sousa, Maria Carolina da Silva
Rato
Bem estar animal
Parâmetros não invasivos
Enriquecimento Ambiental
Mouse
Animal welfare
Non invasive Parameters
Environmental Enrichment
title_short Use of Environmental Enrichment as a Clinical Methodology During Acute Experimental Infection by Trypanosoma Cruzi
title_full Use of Environmental Enrichment as a Clinical Methodology During Acute Experimental Infection by Trypanosoma Cruzi
title_fullStr Use of Environmental Enrichment as a Clinical Methodology During Acute Experimental Infection by Trypanosoma Cruzi
title_full_unstemmed Use of Environmental Enrichment as a Clinical Methodology During Acute Experimental Infection by Trypanosoma Cruzi
title_sort Use of Environmental Enrichment as a Clinical Methodology During Acute Experimental Infection by Trypanosoma Cruzi
author Sousa, Maria Carolina da Silva
author_facet Sousa, Maria Carolina da Silva
Rossi, Maria Inês Doria
Evagelista, Alexandre Andrade
Oliveira, Gabriel Melo de
author_role author
author2 Rossi, Maria Inês Doria
Evagelista, Alexandre Andrade
Oliveira, Gabriel Melo de
author2_role author
author
author
dc.contributor.author.fl_str_mv Sousa, Maria Carolina da Silva
Rossi, Maria Inês Doria
Evagelista, Alexandre Andrade
Oliveira, Gabriel Melo de
dc.subject.other.pt_BR.fl_str_mv Rato
Bem estar animal
Parâmetros não invasivos
Enriquecimento Ambiental
topic Rato
Bem estar animal
Parâmetros não invasivos
Enriquecimento Ambiental
Mouse
Animal welfare
Non invasive Parameters
Environmental Enrichment
dc.subject.en.pt_BR.fl_str_mv Mouse
Animal welfare
Non invasive Parameters
Environmental Enrichment
description Fundação Oswaldo Cruz. Instituto de Ciência e Tecnologia em Biomodelos. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-07-30T14:29:28Z
dc.date.available.fl_str_mv 2021-07-30T14:29:28Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUSA, Maria Carolina da Silva et al. Use of Environmental Enrichment as a Clinical Methodology During Acute Experimental Infection by Trypanosoma Cruzi. American Journal of Biomedical Research, v. 13, n. 4, 8 p, July 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48426
dc.identifier.issn.pt_BR.fl_str_mv 2642-1747
dc.identifier.doi.none.fl_str_mv 10.34297/AJBSR.2021.13.001886
identifier_str_mv SOUSA, Maria Carolina da Silva et al. Use of Environmental Enrichment as a Clinical Methodology During Acute Experimental Infection by Trypanosoma Cruzi. American Journal of Biomedical Research, v. 13, n. 4, 8 p, July 2021.
2642-1747
10.34297/AJBSR.2021.13.001886
url https://www.arca.fiocruz.br/handle/icict/48426
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Biomedical Science
publisher.none.fl_str_mv Biomedical Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/48426/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/48426/2/GabrielOliveira_Alexandrevagelista_etal_IOC_2021.pdf
https://www.arca.fiocruz.br/bitstream/icict/48426/3/GabrielOliveira_Alexandrevagelista_etal_IOC_2021.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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