A Pyrimidine-â-carboline and Other Alkaloids from Annona foetida with Antileishmanial Activity
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2006 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/38972 |
Resumo: | Universidade Federal do Amazonas. Departamento de Química. Coroado, Manaus, AM. |
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Costa, Emmanoel VilaçaPinheiro, Maria Lúcia B.Xavier, Clahildek M.Silva, Jefferson R. A.Amaral, Ana Cláudia F.Souza, Afonso D. L.Barison, AnderssonCampos, Francinete R.Ferreira, Antonio G.Machado, Gérzia M. C.Leon, Leonor L. P.2020-01-03T15:46:56Z2020-01-03T15:46:56Z2006COSTA, Emmanoel Vilaça et al. A Pyrimidine-â-carboline and Other Alkaloids from Annona foetida with Antileishmanial Activity. Journal of Natural Products, v. 69, p. 292-294, 2006.0163-3864https://www.arca.fiocruz.br/handle/icict/3897210.1021/np050422s1520-6025engAmerican Chemical SocietyAlcalóidesAtividade antileishmanialLeishmania braziliensisAlkaloidsAnnona foetidaAntileishmanial ActivityPyrimidine-â-carbolineA Pyrimidine-â-carboline and Other Alkaloids from Annona foetida with Antileishmanial Activityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Amazonas. Departamento de Química. Coroado, Manaus, AM.Universidade Federal do Amazonas. Departamento de Química. Coroado, Manaus, AM.Universidade Federal do Amazonas. Departamento de Química. Coroado, Manaus, AM.Universidade Federal do Amazonas. Departamento de Química. Coroado, Manaus, AM.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Amazonas. Departamento de Química. Coroado, Manaus, AM.Universidade Federal de São Carlos. São Carlos, SP, Brasil.Universidade Federal de São Carlos. São Carlos, SP, Brasil.Universidade Federal de São Carlos. São Carlos, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Bioassay-guided fractionation of the bark extract of Annona foetida afforded a new antileishmanial pyrimidine-â-carboline alkaloid, N-hydroxyannomontine (1), together with the previously reported annomontine (2), O-methylmoschatoline (3), and liriodenine (4). The structure of compound 1 was established on the basis of extensive 1D and 2D NMR and MS analyses. This is the third reported pyrimidine-â-carboline-type alkaloid and is particularly important for Annona genus chemotaxonomy. In addition, all compounds exhibit in vitro antileishmanial activity against promastigote forms of Leishmania braziliensis. Compounds 2 and 4 showed better activity than compounds 1 and 3 against L. braziliensis. Compound 2 was not active against L. guyanensis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/38972/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGerziaMMachado_LeonorLeon_etal_IOC_2006.pdfGerziaMMachado_LeonorLeon_etal_IOC_2006.pdfapplication/pdf51825https://www.arca.fiocruz.br/bitstream/icict/38972/2/GerziaMMachado_LeonorLeon_etal_IOC_2006.pdf84c0bb66cda03524f7b6729ee5b56bf7MD52TEXTGerziaMMachado_LeonorLeon_etal_IOC_2006.pdf.txtGerziaMMachado_LeonorLeon_etal_IOC_2006.pdf.txtExtracted texttext/plain18658https://www.arca.fiocruz.br/bitstream/icict/38972/3/GerziaMMachado_LeonorLeon_etal_IOC_2006.pdf.txt716ac8e9b727709dfa4e55e57a1ac87cMD53icict/389722022-06-24 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| dc.title.pt_BR.fl_str_mv |
A Pyrimidine-â-carboline and Other Alkaloids from Annona foetida with Antileishmanial Activity |
| title |
A Pyrimidine-â-carboline and Other Alkaloids from Annona foetida with Antileishmanial Activity |
| spellingShingle |
A Pyrimidine-â-carboline and Other Alkaloids from Annona foetida with Antileishmanial Activity Costa, Emmanoel Vilaça Alcalóides Atividade antileishmanial Leishmania braziliensis Alkaloids Annona foetida Antileishmanial Activity Pyrimidine-â-carboline |
| title_short |
A Pyrimidine-â-carboline and Other Alkaloids from Annona foetida with Antileishmanial Activity |
| title_full |
A Pyrimidine-â-carboline and Other Alkaloids from Annona foetida with Antileishmanial Activity |
| title_fullStr |
A Pyrimidine-â-carboline and Other Alkaloids from Annona foetida with Antileishmanial Activity |
| title_full_unstemmed |
A Pyrimidine-â-carboline and Other Alkaloids from Annona foetida with Antileishmanial Activity |
| title_sort |
A Pyrimidine-â-carboline and Other Alkaloids from Annona foetida with Antileishmanial Activity |
| author |
Costa, Emmanoel Vilaça |
| author_facet |
Costa, Emmanoel Vilaça Pinheiro, Maria Lúcia B. Xavier, Clahildek M. Silva, Jefferson R. A. Amaral, Ana Cláudia F. Souza, Afonso D. L. Barison, Andersson Campos, Francinete R. Ferreira, Antonio G. Machado, Gérzia M. C. Leon, Leonor L. P. |
| author_role |
author |
| author2 |
Pinheiro, Maria Lúcia B. Xavier, Clahildek M. Silva, Jefferson R. A. Amaral, Ana Cláudia F. Souza, Afonso D. L. Barison, Andersson Campos, Francinete R. Ferreira, Antonio G. Machado, Gérzia M. C. Leon, Leonor L. P. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Costa, Emmanoel Vilaça Pinheiro, Maria Lúcia B. Xavier, Clahildek M. Silva, Jefferson R. A. Amaral, Ana Cláudia F. Souza, Afonso D. L. Barison, Andersson Campos, Francinete R. Ferreira, Antonio G. Machado, Gérzia M. C. Leon, Leonor L. P. |
| dc.subject.other.pt_BR.fl_str_mv |
Alcalóides Atividade antileishmanial Leishmania braziliensis |
| topic |
Alcalóides Atividade antileishmanial Leishmania braziliensis Alkaloids Annona foetida Antileishmanial Activity Pyrimidine-â-carboline |
| dc.subject.en.pt_BR.fl_str_mv |
Alkaloids Annona foetida Antileishmanial Activity Pyrimidine-â-carboline |
| description |
Universidade Federal do Amazonas. Departamento de Química. Coroado, Manaus, AM. |
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2006 |
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2006 |
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2020-01-03T15:46:56Z |
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2020-01-03T15:46:56Z |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
COSTA, Emmanoel Vilaça et al. A Pyrimidine-â-carboline and Other Alkaloids from Annona foetida with Antileishmanial Activity. Journal of Natural Products, v. 69, p. 292-294, 2006. |
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https://www.arca.fiocruz.br/handle/icict/38972 |
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0163-3864 |
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10.1021/np050422s |
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1520-6025 |
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COSTA, Emmanoel Vilaça et al. A Pyrimidine-â-carboline and Other Alkaloids from Annona foetida with Antileishmanial Activity. Journal of Natural Products, v. 69, p. 292-294, 2006. 0163-3864 10.1021/np050422s 1520-6025 |
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