Folate, vitamin B12 and total homocysteine levels in neonates from Brazil.

Detalhes bibliográficos
Autor(a) principal: Couto, Fábio David
Data de Publicação: 2007
Outros Autores: Moreira, L. M. O., Santos, D. B. dos, Reis, Mitermayer Galvão dos, Gonçalves, Marilda de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7540
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
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spelling Couto, Fábio DavidMoreira, L. M. O.Santos, D. B. dosReis, Mitermayer Galvão dosGonçalves, Marilda de Souza2014-04-25T14:18:18Z2014-04-25T14:18:18Z2007COUTO, F. D. et al. Folate, vitamin B12 and total homocysteine levels in neonates from Brazil. European Journal of Clinical Nutrition, v. 61, n. 3, p. 382-386, 2007.0954-3007https://www.arca.fiocruz.br/handle/icict/754010.1038/sj.ejcn.1602528engNature Publishing GroupFolate, vitamin B12 and total homocysteine levels in neonates from Brazil.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilJosé Silveira Foundation-Santo Amaro Hospital. Salvador, BAFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Federal University Bahia. School of Pharmacy. Salvador, BA, BrasilOBJECTIVE: To determine folates, vitamin B12 and total homocysteine levels among neonates from mothers of low or high socioeconomic status. DESIGN: We carried out a cross-sectional transversal study comprising 143 neonates from two maternity hospitals in the city of Salvador, Northeast of Brazil. Cord blood samples were obtained at the time of delivery from newborns from low (group 1, n=77) or high (group 2, n=66) socioeconomic status. The vitamin B12 and folates were analyzed by electrochemiluminescence immunoassay and by a competitive test using a natural folate-binding protein (FBP), respectively. Total homocyteine levels were measured by fluorescence polarization immunoassay. Maternal environmental risk factors for pregnancy complications were obtained from all mothers. RESULTS: Only 2% of women from group 1 received prenatal care/vitamin supplementation, whereas almost all mothers from group 2 (96%) were properly followed. Anemia and/or infections pre- or during pregnancy was more prevalent among mothers of babies from group 1. Folate levels among newborns from group 1 and 2 were 7.38+/-2.71 and 8.83+/-4.06 ng/ml, respectively. No difference in the vitamin B12 levels was determined between groups. In addition, tHcy serum levels were higher among newborns from group 1 compared to those from group 2 (8.54+/-4.06 vs 6.35+/-1.33 micromol/l, respectively; P=0.005). CONCLUSION: These results demonstrate that unprivileged young woman has limited accesses to prenatal care, present high-risk factors that hamper both maternal and newborn health. Maternal and newborn health status could be improved by simply reinforcing the use of folate-enriched diet. 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dc.title.pt_BR.fl_str_mv Folate, vitamin B12 and total homocysteine levels in neonates from Brazil.
title Folate, vitamin B12 and total homocysteine levels in neonates from Brazil.
spellingShingle Folate, vitamin B12 and total homocysteine levels in neonates from Brazil.
Couto, Fábio David
Newborns
Homocysteine
Vitamin B12
Folate
Pregnancy
Socioeconomic status
Ácido Fólico/sangue
Homocisteína/sangue
Recém-Nascido/sangue
Vitamina B 12/sangue
Complexo Vitamínico B/sangue
Adulto
Estudos Transversais
Suplementos Dietéticos
Feminino
Sangue Fetal/química
Humanos
Masculino
Estado Nutricional
Gravidez
Cuidado Pré-Natal
Classe Social
Fatores Socioeconômicos
title_short Folate, vitamin B12 and total homocysteine levels in neonates from Brazil.
title_full Folate, vitamin B12 and total homocysteine levels in neonates from Brazil.
title_fullStr Folate, vitamin B12 and total homocysteine levels in neonates from Brazil.
title_full_unstemmed Folate, vitamin B12 and total homocysteine levels in neonates from Brazil.
title_sort Folate, vitamin B12 and total homocysteine levels in neonates from Brazil.
author Couto, Fábio David
author_facet Couto, Fábio David
Moreira, L. M. O.
Santos, D. B. dos
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
author_role author
author2 Moreira, L. M. O.
Santos, D. B. dos
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Couto, Fábio David
Moreira, L. M. O.
Santos, D. B. dos
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
dc.subject.en.pt_BR.fl_str_mv Newborns
Homocysteine
Vitamin B12
Folate
Pregnancy
Socioeconomic status
topic Newborns
Homocysteine
Vitamin B12
Folate
Pregnancy
Socioeconomic status
Ácido Fólico/sangue
Homocisteína/sangue
Recém-Nascido/sangue
Vitamina B 12/sangue
Complexo Vitamínico B/sangue
Adulto
Estudos Transversais
Suplementos Dietéticos
Feminino
Sangue Fetal/química
Humanos
Masculino
Estado Nutricional
Gravidez
Cuidado Pré-Natal
Classe Social
Fatores Socioeconômicos
dc.subject.decs.pt_BR.fl_str_mv Ácido Fólico/sangue
Homocisteína/sangue
Recém-Nascido/sangue
Vitamina B 12/sangue
Complexo Vitamínico B/sangue
Adulto
Estudos Transversais
Suplementos Dietéticos
Feminino
Sangue Fetal/química
Humanos
Masculino
Estado Nutricional
Gravidez
Cuidado Pré-Natal
Classe Social
Fatores Socioeconômicos
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2014-04-25T14:18:18Z
dc.date.available.fl_str_mv 2014-04-25T14:18:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COUTO, F. D. et al. Folate, vitamin B12 and total homocysteine levels in neonates from Brazil. European Journal of Clinical Nutrition, v. 61, n. 3, p. 382-386, 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7540
dc.identifier.issn.none.fl_str_mv 0954-3007
dc.identifier.doi.none.fl_str_mv 10.1038/sj.ejcn.1602528
identifier_str_mv COUTO, F. D. et al. Folate, vitamin B12 and total homocysteine levels in neonates from Brazil. European Journal of Clinical Nutrition, v. 61, n. 3, p. 382-386, 2007.
0954-3007
10.1038/sj.ejcn.1602528
url https://www.arca.fiocruz.br/handle/icict/7540
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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