In silico search of Myrcia tomentosa (Myrtaceae) antineoplastic potential

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Júlia Alves Nascimento
Data de Publicação: 2022
Outros Autores: Borges, Leonardo Luiz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/53134
Resumo: Pontifícia Universidade Católica de Goiás. Escola de Ciências Médicas e da Vida. Goiânia, GO, Brasil.
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spelling Rodrigues, Júlia Alves NascimentoBorges, Leonardo Luiz2022-06-08T19:33:38Z2022-06-08T19:33:38Z2022RODRIGUES, Júlia Alves Nascimento; BORGES, Leonardo Luiz. In silico search of Myrcia tomentosa (Myrtaceae) antineoplastic potential. Revista Fitos, v. 16, n. 1, p. 9-17, Mar. 2022.1808-9569https://www.arca.fiocruz.br/handle/icict/5313410.32712/2446-4775.2022.11372446-4775engFundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e SaúdeIn silico search of Myrcia tomentosa (Myrtaceae) antineoplastic potentialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePontifícia Universidade Católica de Goiás. Escola de Ciências Médicas e da Vida. Goiânia, GO, Brasil.Pontifícia Universidade Católica de Goiás. Escola de Ciências Médicas e da Vida. Goiânia, GO, Brasil / Universidade Estadual de Goiás. Anápolis, GO, Brasil.Myrcia tomentosa, popularly known as “guava-brava”, belongs to the Myrtaceae family, widely used in folk medicine to treat various diseases. There already are studies proving the effectiveness of several of its components. However, there are few specific articles on the biological potential of M. tomentosa compounds. The aim of this study was to evaluate the potential antineoplastic activity from M. tomentosa. For these, we performed in silico analysis to evaluate pharmacological and toxicological activities, besides the interaction between M. tomentosa molecules with the human targets from redocking analysis. Our results showed that α-cadinol was the highest score molecule between the 11 compounds present in screening analysis. Among its possible actions, antineoplastic activity and interaction with cytochrome P450 19 A1 were found. This cytochrome was related to breast cancer and is the main target of the antineoplastic drugs used in this cancer’s treatment. Therefore, we believe that α-cadinol should be considered in future in vitro and in vivo assays against breast cancer.Breast cancerMedicinal plantsα-cadinolMolecular dockinginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/53134/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALl_l_et_all.pdfapplication/pdf582378https://www.arca.fiocruz.br/bitstream/icict/53134/2/l_l_et_all.pdfc91845ab8c604feb9db73a8664fee9c4MD52icict/531342022-12-12 10:58:21.666oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-12-12T13:58:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv In silico search of Myrcia tomentosa (Myrtaceae) antineoplastic potential
title In silico search of Myrcia tomentosa (Myrtaceae) antineoplastic potential
spellingShingle In silico search of Myrcia tomentosa (Myrtaceae) antineoplastic potential
Rodrigues, Júlia Alves Nascimento
Breast cancer
Medicinal plants
α-cadinol
Molecular docking
title_short In silico search of Myrcia tomentosa (Myrtaceae) antineoplastic potential
title_full In silico search of Myrcia tomentosa (Myrtaceae) antineoplastic potential
title_fullStr In silico search of Myrcia tomentosa (Myrtaceae) antineoplastic potential
title_full_unstemmed In silico search of Myrcia tomentosa (Myrtaceae) antineoplastic potential
title_sort In silico search of Myrcia tomentosa (Myrtaceae) antineoplastic potential
author Rodrigues, Júlia Alves Nascimento
author_facet Rodrigues, Júlia Alves Nascimento
Borges, Leonardo Luiz
author_role author
author2 Borges, Leonardo Luiz
author2_role author
dc.contributor.author.fl_str_mv Rodrigues, Júlia Alves Nascimento
Borges, Leonardo Luiz
dc.subject.en.en_US.fl_str_mv Breast cancer
Medicinal plants
α-cadinol
Molecular docking
topic Breast cancer
Medicinal plants
α-cadinol
Molecular docking
description Pontifícia Universidade Católica de Goiás. Escola de Ciências Médicas e da Vida. Goiânia, GO, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-06-08T19:33:38Z
dc.date.available.fl_str_mv 2022-06-08T19:33:38Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RODRIGUES, Júlia Alves Nascimento; BORGES, Leonardo Luiz. In silico search of Myrcia tomentosa (Myrtaceae) antineoplastic potential. Revista Fitos, v. 16, n. 1, p. 9-17, Mar. 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/53134
dc.identifier.issn.none.fl_str_mv 1808-9569
dc.identifier.doi.none.fl_str_mv 10.32712/2446-4775.2022.1137
dc.identifier.eissn.none.fl_str_mv 2446-4775
identifier_str_mv RODRIGUES, Júlia Alves Nascimento; BORGES, Leonardo Luiz. In silico search of Myrcia tomentosa (Myrtaceae) antineoplastic potential. Revista Fitos, v. 16, n. 1, p. 9-17, Mar. 2022.
1808-9569
10.32712/2446-4775.2022.1137
2446-4775
url https://www.arca.fiocruz.br/handle/icict/53134
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e Saúde
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e Saúde
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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