The burden of mucormycosis in HIV-infected patients: a systematic review

Detalhes bibliográficos
Autor(a) principal: Moreira, José
Data de Publicação: 2016
Outros Autores: Varon, Andrea, Galhardo, Maria Clara, Santos, Fabio, Lyra, Marcelo, Castro, Rodolfo, Oliveira, Raquel, Lamas, Cristiane C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32734
Resumo: 2020-04-24
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spelling Moreira, JoséVaron, AndreaGalhardo, Maria ClaraSantos, FabioLyra, MarceloCastro, RodolfoOliveira, RaquelLamas, Cristiane C.2019-04-25T12:47:10Z2019-04-25T12:47:10Z2016MOREIRA, José et al. The burden of mucormycosis in HIV-infected patients: a systematic review. Journal of Infection, v. 73, p. 181-188, 2016.0163-4453https://www.arca.fiocruz.br/handle/icict/3273410.1016/j.jinf.2016.06.013engElsevierThe burden of mucormycosis in HIV-infected patients: a systematic reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-04-24Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade do Grande Rio. Infectious Disease Department. Rio de Janeiro, RJ, Brazil / Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil.Objectives: Mucormycosis is an invasive fungal infection afflicting immunocompromised patients, causing a significant degree of morbidity and mortality. The purpose of the study was to provide a comprehensive analysis describing the epidemiology and outcome of mucormycosis in the scenario of HIV infection. Methods: We systematically searched PubMed for reports about mucormycosis associated with HIV. Eligible studies describe the predisposing factor, clinical form, treatment, and survival outcome. Results: We included 61 articles from 212 reviewed abstracts, corresponding to 67 cases. Patients were mostly men (68.2%) with a median CD4þ count of 47 [IQR 17e100] cells/mm3 . Intravenous drug use (50%), neutropenia (29.7%) and corticosteroid use (25%) were the predominant associated factors. The main clinical forms were disseminated (20.9%), renal (19.4%), and rhino-cerebral (17.9%). Rhizopus (45.5%) and Lichtheimia spp (30.3%) were the main fungal isolates. Treatment consisted of antifungal therapy and surgery in 38.8%. Overall mortality rate was 52.2%, and varied with the site of infection: 92.9% for disseminated disease, 62.5% for cerebral disease, 60% for pulmonary infection, and 36.4% for cutaneous infection. Survival was worse for those who did not initiate antifungals (p Z .04), who were antiretroviral naïve (p Z .01), who were admitted to ICU (p Z .003) or had disseminated disease (p Z .007). Conclusions: Mucormycosis is a life-threatening infection in HIV patients and clinician should be aware of this co-infection in the differential diagnosis of HIV opportunistic infections.MucormycosisHIVAIDSDisseminationMortalityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/32734/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Moreira_José_etal__2016_INI.pdfve_Moreira_José_etal__2016_INI.pdfapplication/pdf479582https://www.arca.fiocruz.br/bitstream/icict/32734/2/ve_Moreira_Jos%c3%a9_etal__2016_INI.pdff979edb629b122ed5208449c9ed28106MD52TEXTve_Moreira_José_etal__2016_INI.pdf.txtve_Moreira_José_etal__2016_INI.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The burden of mucormycosis in HIV-infected patients: a systematic review
title The burden of mucormycosis in HIV-infected patients: a systematic review
spellingShingle The burden of mucormycosis in HIV-infected patients: a systematic review
Moreira, José
Mucormycosis
HIV
AIDS
Dissemination
Mortality
title_short The burden of mucormycosis in HIV-infected patients: a systematic review
title_full The burden of mucormycosis in HIV-infected patients: a systematic review
title_fullStr The burden of mucormycosis in HIV-infected patients: a systematic review
title_full_unstemmed The burden of mucormycosis in HIV-infected patients: a systematic review
title_sort The burden of mucormycosis in HIV-infected patients: a systematic review
author Moreira, José
author_facet Moreira, José
Varon, Andrea
Galhardo, Maria Clara
Santos, Fabio
Lyra, Marcelo
Castro, Rodolfo
Oliveira, Raquel
Lamas, Cristiane C.
author_role author
author2 Varon, Andrea
Galhardo, Maria Clara
Santos, Fabio
Lyra, Marcelo
Castro, Rodolfo
Oliveira, Raquel
Lamas, Cristiane C.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moreira, José
Varon, Andrea
Galhardo, Maria Clara
Santos, Fabio
Lyra, Marcelo
Castro, Rodolfo
Oliveira, Raquel
Lamas, Cristiane C.
dc.subject.en.pt_BR.fl_str_mv Mucormycosis
HIV
AIDS
Dissemination
Mortality
topic Mucormycosis
HIV
AIDS
Dissemination
Mortality
description 2020-04-24
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2019-04-25T12:47:10Z
dc.date.available.fl_str_mv 2019-04-25T12:47:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MOREIRA, José et al. The burden of mucormycosis in HIV-infected patients: a systematic review. Journal of Infection, v. 73, p. 181-188, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32734
dc.identifier.issn.pt_BR.fl_str_mv 0163-4453
dc.identifier.doi.none.fl_str_mv 10.1016/j.jinf.2016.06.013
identifier_str_mv MOREIRA, José et al. The burden of mucormycosis in HIV-infected patients: a systematic review. Journal of Infection, v. 73, p. 181-188, 2016.
0163-4453
10.1016/j.jinf.2016.06.013
url https://www.arca.fiocruz.br/handle/icict/32734
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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