Molecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET Study

Detalhes bibliográficos
Autor(a) principal: Kurizky, Patricia
Data de Publicação: 2021
Outros Autores: Nóbrega, Otávio T., Soares, Alexandre Anderson De Sousa Munhoz, Aires, Rodrigo Barbosa, Albuquerque, Cleandro Pires de, Nicola, André Moraes, Albuquerque, Patrícia, Carvalho, Andréa Teixeira de, Naves, Luciana Ansaneli, Fontes, Wagner, Luz, Isabelle Souza, Felicori, Liza, Gomides, Ana Paulo Monteiro, Silva, Dayde Lane Mendonça, Espindola, Laila Salmen, Martins Filho, Olindo Assis, Lima, Sheila Maria Barbosa de, Mota, Licia Maria Henrique, Gomes, Ciro Martins
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51341
Resumo: Programa de Pós-graduação em Ciências Médicas. Faculdade de Medicina. University of Brasília. Brasília, DF, Brazil / Hospital Universitário de Brasília. University of Brasília. Brasília, DF, Brazil.
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spelling Kurizky, PatriciaNóbrega, Otávio T.Soares, Alexandre Anderson De Sousa MunhozAires, Rodrigo BarbosaAlbuquerque, Cleandro Pires deNicola, André MoraesAlbuquerque, PatríciaCarvalho, Andréa Teixeira deNaves, Luciana AnsaneliFontes, WagnerLuz, Isabelle SouzaFelicori, LizaGomides, Ana Paulo MonteiroSilva, Dayde Lane MendonçaEspindola, Laila SalmenMartins Filho, Olindo AssisLima, Sheila Maria Barbosa deMota, Licia Maria HenriqueGomes, Ciro Martins2022-02-21T17:09:19Z2022-02-21T17:09:19Z2021KURIZKY, Patricia et al. Molecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET Study. JMIR Research Protocols, v. 10, n. 3, p. 1-13, e24211, 2021.1929-0748https://www.arca.fiocruz.br/handle/icict/5134110.2196/24211engJMIR PublicationsMolecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePrograma de Pós-graduação em Ciências Médicas. Faculdade de Medicina. University of Brasília. Brasília, DF, Brazil / Hospital Universitário de Brasília. University of Brasília. Brasília, DF, Brazil.Programa de Pós-graduação em Ciências Médicas. Faculdade de Medicina. University of Brasília. Brasília, DF, Brazil.Programa de Pós-graduação em Ciências Médicas. Faculdade de Medicina. University of Brasília. Brasília, DF, Brazil.Programa de Pós-graduação em Ciências Médicas. Faculdade de Medicina. University of Brasília. Brasília, DF, Brazil.Programa de Pós-graduação em Ciências Médicas. Faculdade de Medicina. University of Brasília. Brasília, DF, Brazil / Hospital Universitário de Brasília. University of Brasília. Brasília, DF, Brazil.Programa de Pós-graduação em Ciências Médicas. Faculdade de Medicina. University of Brasília. Brasília, DF, Brazil.Faculdade de Ceilândia. University of Brasília. Brasília, DF, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil.Programa de Pós-graduação em Ciências Médicas. Faculdade de Medicina. University of Brasília. Brasília, DF, Brazil / Hospital Universitário de Brasília. University of Brasília. Brasília, DF, Brazil.Instituto de Ciências Biológicas. University of Brasília. Brasília, DF, Brazil.Instituto de Ciências Biológicas. University of Brasília. Brasília, DF, Brazil.Instituto de Ciências Biológicas. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.Centro Universitário de Brasília. Brasília, DF, Brazil.Hospital Universitário de Brasília. University of Brasília. Brasília, DF, Brazil / Faculdade de Ciências da Saúde. University of Brasília. Brasília, DF, Brazil.Programa de Pós-graduação em Ciências Médicas. Faculdade de Medicina. University of Brasília. Brasília, DF, Brazil / Faculdade de Ciências da Saúde. University of Brasília. Brasília, DF, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos Bio-Manguinhos. Rio de Janeiro, RJ, BrazilPrograma de Pós-graduação em Ciências Médicas. Faculdade de Medicina. University of Brasília. Brasília, DF, Brazil / Hospital Universitário de Brasília. University of Brasília. Brasília, DF, Brazil.Programa de Pós-graduação em Ciências Médicas. Faculdade de Medicina. University of Brasília. Brasília, DF, Brazil / Hospital Universitário de Brasília. University of Brasília. Brasília, DF, Brazil.Background: Since the beginning of the COVID-19 pandemic, the world's attention has been focused on better understanding the relation between the human host and the SARS-CoV-2 virus, as its action has led to hundreds of thousands of deaths. Objective: In this context, we decided to study certain consequences of the abundant cytokine release over the innate and adaptive immune systems, inflammation, and hemostasis, comparing mild and severe forms of COVID-19. Methods: To accomplish these aims, we will analyze demographic characteristics, biochemical tests, immune biomarkers, leukocyte phenotyping, immunoglobulin profile, hormonal release (cortisol and prolactin), gene expression, thromboelastometry, neutralizing antibodies, metabolic profile, and neutrophil function (reactive oxygen species production, neutrophil extracellular trap production, phagocytosis, migration, gene expression, and proteomics). A total of 200 reverse transcription polymerase chain reaction-confirmed patients will be enrolled and divided into two groups: mild/moderate or severe/critical forms of COVID-19. Blood samples will be collected at different times: at inclusion and after 9 and 18 days, with an additional 3-day sample for severe patients. We believe that this information will provide more knowledge for future studies that will provide more robust and useful clinical information that may allow for better decisions at the front lines of health care. Results: The recruitment began in June 2020 and is still in progress. It is expected to continue until February 2021. Data analysis is scheduled to start after all data have been collected. The coagulation study branch is complete and is already in the analysis phase. Conclusions: This study is original in terms of the different parameters analyzed in the same sample of patients with COVID-19. The project, which is currently in the data collection phase, was approved by the Brazilian Committee of Ethics in Human Research (CAAE 30846920.7.0000.0008).COVID-19TARGETBiomarkerCohortCytokine profileDesignGeneticsImmune systemImmunologyMetabolomicsNeutralizing antibodiesNeutrophil functionPrognosisProteomicsThromboelastometryVirusinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/51341/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALMolecular and Cellular Biomarkers of COVID-19 Prognosis.pdfMolecular and Cellular Biomarkers of COVID-19 Prognosis.pdfapplication/pdf611387https://www.arca.fiocruz.br/bitstream/icict/51341/2/Molecular%20and%20Cellular%20Biomarkers%20of%20COVID-19%20Prognosis.pdf3c8af0f926c8888e791a0b9bc5063bbbMD52icict/513412022-03-09 22:32:30.632oai:www.arca.fiocruz.br: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Repositório 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dc.title.pt_BR.fl_str_mv Molecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET Study
title Molecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET Study
spellingShingle Molecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET Study
Kurizky, Patricia
COVID-19
TARGET
Biomarker
Cohort
Cytokine profile
Design
Genetics
Immune system
Immunology
Metabolomics
Neutralizing antibodies
Neutrophil function
Prognosis
Proteomics
Thromboelastometry
Virus
title_short Molecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET Study
title_full Molecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET Study
title_fullStr Molecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET Study
title_full_unstemmed Molecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET Study
title_sort Molecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET Study
author Kurizky, Patricia
author_facet Kurizky, Patricia
Nóbrega, Otávio T.
Soares, Alexandre Anderson De Sousa Munhoz
Aires, Rodrigo Barbosa
Albuquerque, Cleandro Pires de
Nicola, André Moraes
Albuquerque, Patrícia
Carvalho, Andréa Teixeira de
Naves, Luciana Ansaneli
Fontes, Wagner
Luz, Isabelle Souza
Felicori, Liza
Gomides, Ana Paulo Monteiro
Silva, Dayde Lane Mendonça
Espindola, Laila Salmen
Martins Filho, Olindo Assis
Lima, Sheila Maria Barbosa de
Mota, Licia Maria Henrique
Gomes, Ciro Martins
author_role author
author2 Nóbrega, Otávio T.
Soares, Alexandre Anderson De Sousa Munhoz
Aires, Rodrigo Barbosa
Albuquerque, Cleandro Pires de
Nicola, André Moraes
Albuquerque, Patrícia
Carvalho, Andréa Teixeira de
Naves, Luciana Ansaneli
Fontes, Wagner
Luz, Isabelle Souza
Felicori, Liza
Gomides, Ana Paulo Monteiro
Silva, Dayde Lane Mendonça
Espindola, Laila Salmen
Martins Filho, Olindo Assis
Lima, Sheila Maria Barbosa de
Mota, Licia Maria Henrique
Gomes, Ciro Martins
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kurizky, Patricia
Nóbrega, Otávio T.
Soares, Alexandre Anderson De Sousa Munhoz
Aires, Rodrigo Barbosa
Albuquerque, Cleandro Pires de
Nicola, André Moraes
Albuquerque, Patrícia
Carvalho, Andréa Teixeira de
Naves, Luciana Ansaneli
Fontes, Wagner
Luz, Isabelle Souza
Felicori, Liza
Gomides, Ana Paulo Monteiro
Silva, Dayde Lane Mendonça
Espindola, Laila Salmen
Martins Filho, Olindo Assis
Lima, Sheila Maria Barbosa de
Mota, Licia Maria Henrique
Gomes, Ciro Martins
dc.subject.en.pt_BR.fl_str_mv COVID-19
TARGET
Biomarker
Cohort
Cytokine profile
Design
Genetics
Immune system
Immunology
Metabolomics
Neutralizing antibodies
Neutrophil function
Prognosis
Proteomics
Thromboelastometry
Virus
topic COVID-19
TARGET
Biomarker
Cohort
Cytokine profile
Design
Genetics
Immune system
Immunology
Metabolomics
Neutralizing antibodies
Neutrophil function
Prognosis
Proteomics
Thromboelastometry
Virus
description Programa de Pós-graduação em Ciências Médicas. Faculdade de Medicina. University of Brasília. Brasília, DF, Brazil / Hospital Universitário de Brasília. University of Brasília. Brasília, DF, Brazil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-02-21T17:09:19Z
dc.date.available.fl_str_mv 2022-02-21T17:09:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv KURIZKY, Patricia et al. Molecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET Study. JMIR Research Protocols, v. 10, n. 3, p. 1-13, e24211, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51341
dc.identifier.issn.pt_BR.fl_str_mv 1929-0748
dc.identifier.doi.none.fl_str_mv 10.2196/24211
identifier_str_mv KURIZKY, Patricia et al. Molecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET Study. JMIR Research Protocols, v. 10, n. 3, p. 1-13, e24211, 2021.
1929-0748
10.2196/24211
url https://www.arca.fiocruz.br/handle/icict/51341
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv JMIR Publications
publisher.none.fl_str_mv JMIR Publications
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51341/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51341/2/Molecular%20and%20Cellular%20Biomarkers%20of%20COVID-19%20Prognosis.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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