Vaccine Mismatches, Viral Circulation, and Clinical Severity Patterns of Influenza B Victoria and Yamagata Infections in Brazil over the Decade 2010–2020: A Statistical and Phylogeny–Trait Analyses

Detalhes bibliográficos
Autor(a) principal: Costa, Jaline Cabral da
Data de Publicação: 2022
Outros Autores: Siqueira, Marilda Mendonça, Brown, David, Lopes, Jonathan Oliveira, Costa, Braulia Caetano da, Gama, Eric Lopes, Oliveira, Maria de Lourdes Aguiar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/54089
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.
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spelling Costa, Jaline Cabral daSiqueira, Marilda MendonçaBrown, DavidLopes, Jonathan OliveiraCosta, Braulia Caetano daGama, Eric LopesOliveira, Maria de Lourdes Aguiar2022-07-30T19:08:26Z2022-07-30T19:08:26Z2022COSTA, Jaline Cabral da Costa et al. Vaccine Mismatches, Viral Circulation, and Clinical Severity Patterns of Influenza B Victoria and Yamagata Infections in Brazil over the Decade 2010–2020: A Statistical and Phylogeny–Trait Analyses. Viruses, v. 14, 1477, p. 1 - 10, July 2022.1999-4915https://www.arca.fiocruz.br/handle/icict/5408910.3390/v14071477engMDPILinhagens de influenza BIncompatibilidade de vacinasDoença clínicaFilogenéticaAssociação de filogenia-característicaInfluenza B lineagesVaccine mismatchClinical diseasePhylogeneticsPhylogeny–trait associationVaccine Mismatches, Viral Circulation, and Clinical Severity Patterns of Influenza B Victoria and Yamagata Infections in Brazil over the Decade 2010–2020: A Statistical and Phylogeny–Trait Analysesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.Worldwide, infections by influenza viruses are considered a major public health challenge. In this study, influenza B vaccine mismatches and clinical aspects of Victoria and Yamagata infections in Brazil were assessed. Clinical samples were collected from patients suspected of influenza infection. In addition, sociodemographic, clinical, and epidemiological information were collected by the epidemiological surveillance teams. Influenza B lineages were determined by real-time RT-PCR and/or Sanger sequencing. In addition, putative phylogeny–trait associations were assessed by using the BaTS program after phylogenetic reconstruction by a Bayesian Markov Chain Monte Carlo method (BEAST software package). Over 2010–2020, B/Victoria and B/Yamagata-like lineages cocirculated in almost all seasonal epidemics, with B/Victoria predominance in most years. Vaccine mismatches between circulating viruses and the trivalent vaccine strains occurred in five of the eleven seasons (45.5%). No significant differences were identified in clinical presentation or disease severity caused by both strains, but subjects infected by B/Victoria-like viruses were significantly younger than their B/Yamagata-like counterparts (16.7 vs. 31.4 years, p < 0.001). This study contributes to a better understanding of the circulation patterns and clinical outcomes of B/Victoria- and B/Yamagatalike lineages in Brazil and advocate for the inclusion of a quadrivalent vaccine in the scope of the Brazilian National Immunization Program.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54089/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJalineCabral_Costa_etal_IOC_2022.pdfJalineCabral_Costa_etal_IOC_2022.pdfapplication/pdf1225223https://www.arca.fiocruz.br/bitstream/icict/54089/2/JalineCabral_Costa_etal_IOC_2022.pdf29115e4718e1d77f5d1cf52071cfc42aMD52icict/540892022-07-30 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dc.title.pt_BR.fl_str_mv Vaccine Mismatches, Viral Circulation, and Clinical Severity Patterns of Influenza B Victoria and Yamagata Infections in Brazil over the Decade 2010–2020: A Statistical and Phylogeny–Trait Analyses
title Vaccine Mismatches, Viral Circulation, and Clinical Severity Patterns of Influenza B Victoria and Yamagata Infections in Brazil over the Decade 2010–2020: A Statistical and Phylogeny–Trait Analyses
spellingShingle Vaccine Mismatches, Viral Circulation, and Clinical Severity Patterns of Influenza B Victoria and Yamagata Infections in Brazil over the Decade 2010–2020: A Statistical and Phylogeny–Trait Analyses
Costa, Jaline Cabral da
Linhagens de influenza B
Incompatibilidade de vacinas
Doença clínica
Filogenética
Associação de filogenia-característica
Influenza B lineages
Vaccine mismatch
Clinical disease
Phylogenetics
Phylogeny–trait association
title_short Vaccine Mismatches, Viral Circulation, and Clinical Severity Patterns of Influenza B Victoria and Yamagata Infections in Brazil over the Decade 2010–2020: A Statistical and Phylogeny–Trait Analyses
title_full Vaccine Mismatches, Viral Circulation, and Clinical Severity Patterns of Influenza B Victoria and Yamagata Infections in Brazil over the Decade 2010–2020: A Statistical and Phylogeny–Trait Analyses
title_fullStr Vaccine Mismatches, Viral Circulation, and Clinical Severity Patterns of Influenza B Victoria and Yamagata Infections in Brazil over the Decade 2010–2020: A Statistical and Phylogeny–Trait Analyses
title_full_unstemmed Vaccine Mismatches, Viral Circulation, and Clinical Severity Patterns of Influenza B Victoria and Yamagata Infections in Brazil over the Decade 2010–2020: A Statistical and Phylogeny–Trait Analyses
title_sort Vaccine Mismatches, Viral Circulation, and Clinical Severity Patterns of Influenza B Victoria and Yamagata Infections in Brazil over the Decade 2010–2020: A Statistical and Phylogeny–Trait Analyses
author Costa, Jaline Cabral da
author_facet Costa, Jaline Cabral da
Siqueira, Marilda Mendonça
Brown, David
Lopes, Jonathan Oliveira
Costa, Braulia Caetano da
Gama, Eric Lopes
Oliveira, Maria de Lourdes Aguiar
author_role author
author2 Siqueira, Marilda Mendonça
Brown, David
Lopes, Jonathan Oliveira
Costa, Braulia Caetano da
Gama, Eric Lopes
Oliveira, Maria de Lourdes Aguiar
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, Jaline Cabral da
Siqueira, Marilda Mendonça
Brown, David
Lopes, Jonathan Oliveira
Costa, Braulia Caetano da
Gama, Eric Lopes
Oliveira, Maria de Lourdes Aguiar
dc.subject.other.pt_BR.fl_str_mv Linhagens de influenza B
Incompatibilidade de vacinas
Doença clínica
Filogenética
Associação de filogenia-característica
topic Linhagens de influenza B
Incompatibilidade de vacinas
Doença clínica
Filogenética
Associação de filogenia-característica
Influenza B lineages
Vaccine mismatch
Clinical disease
Phylogenetics
Phylogeny–trait association
dc.subject.en.pt_BR.fl_str_mv Influenza B lineages
Vaccine mismatch
Clinical disease
Phylogenetics
Phylogeny–trait association
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-07-30T19:08:26Z
dc.date.available.fl_str_mv 2022-07-30T19:08:26Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA, Jaline Cabral da Costa et al. Vaccine Mismatches, Viral Circulation, and Clinical Severity Patterns of Influenza B Victoria and Yamagata Infections in Brazil over the Decade 2010–2020: A Statistical and Phylogeny–Trait Analyses. Viruses, v. 14, 1477, p. 1 - 10, July 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54089
dc.identifier.issn.pt_BR.fl_str_mv 1999-4915
dc.identifier.doi.none.fl_str_mv 10.3390/v14071477
identifier_str_mv COSTA, Jaline Cabral da Costa et al. Vaccine Mismatches, Viral Circulation, and Clinical Severity Patterns of Influenza B Victoria and Yamagata Infections in Brazil over the Decade 2010–2020: A Statistical and Phylogeny–Trait Analyses. Viruses, v. 14, 1477, p. 1 - 10, July 2022.
1999-4915
10.3390/v14071477
url https://www.arca.fiocruz.br/handle/icict/54089
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/54089/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/54089/2/JalineCabral_Costa_etal_IOC_2022.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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