Health Education through Analogies: Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazil

Detalhes bibliográficos
Autor(a) principal: Gazzinelli, Maria Flavia
Data de Publicação: 2010
Outros Autores: Lobato, Lucas, Matoso, Leonardo Ferreira, Avila, Renato, Marques, Rita de Cassia, Brown, Ami Shah, Oliveira, Rodrigo Corrêa de, Bethony, Jeffrey Michael, Diemert, David J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5615
Resumo: Universidade Federal de Minas Gerais. Faculdade de Enfermagem. Belo Horizonte, MG, Brazil.
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spelling Gazzinelli, Maria FlaviaLobato, LucasMatoso, Leonardo FerreiraAvila, RenatoMarques, Rita de CassiaBrown, Ami ShahOliveira, Rodrigo Corrêa deBethony, Jeffrey MichaelDiemert, David J.2012-09-28T15:00:30Z2012-09-28T15:00:30Z2010GAZZINELLI, Maria Flavia et al. Health Education through Analogies: Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazil. PLoS Negl .Trop. Dis., v. 4, n. 7, p. 1-12, 2010.19352727https://www.arca.fiocruz.br/handle/icict/561510.1371/journal.pntd.0000749engPublic Library of ScienceGazzinelli MF, Lobato L, Matoso L, Avila R, de Cassia Marques R, et al. (2010) Health Education through Analogies: Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazil. PLoS Negl Trop Dis 4(7): e749Health Education through Analogies: Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Faculdade de Enfermagem. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Faculdade de Enfermagem. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Faculdade de Enfermagem. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Faculdade de Enfermagem. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Faculdade de Enfermagem. Belo Horizonte, MG, Brazil.Albert B. Sabin Vaccine Institute. Washington, DC, USA.Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratório de Imunologia. Belo Horizonte, MG, Brazil.George Washington University. Department of Microbiology, Immunology and Tropical Medicine, Washington, DC, USA.Albert B. Sabin Vaccine Institute. Washington, District of Columbia, United States of America/ George Washington University. Department of Microbiology, Immunology and Tropical Medicine, Washington, DC, USA.Background: Obtaining informed consent for clinical trials is especially challenging when working in rural, resource-limited areas, where there are often high levels of illiteracy and lack of experience with clinical research. Such an area, a remote field site in the northeastern part of the state of Minas Gerais, Brazil, is currently being prepared for clinical trials of experimental hookworm vaccines. This study was conducted to assess whether special educational tools can be developed to increase the knowledge and comprehension of potential clinical trial participants and thereby enable them to make truly informed decisions to participate in such research. Methodology/Principal Findings: An informational video was produced to explain the work of the research team and the first planned hookworm vaccine trial, using a pedagogical method based on analogies. Seventy-two adults living in a rural community of Minas Gerais were administered a structured questionnaire that assessed their knowledge of hookworm, of research and of the planned hookworm vaccine trial, as well as their attitudes and perceptions about the researchers and participation in future vaccine trials. The questionnaire was administered before being shown the educational video and two months after and the results compared. After viewing the video, significant improvements in knowledge related to hookworm infection and its health impact were observed: using a composite score combining related questions for which correct answers were assigned a value of 1 and incorrect answers a value of 0, participants had a mean score of 0.76 postvideo compared to 0.68 pre-video (p = 0.0001). Similar improvements were seen in understanding the purpose of vaccination and the possible adverse effects of an experimental vaccine. Although 100% of participants expressed a positive opinion of the researchers even before viewing the film and over 90% said that they would participate in a hookworm vaccine trial, an increase in the number who expressed fear of being vaccinated with a novel vaccine was seen after viewing the video (51.4% post-video versus 29.2% pre-video). Increases were also seen in the proportion who thought that participation in a vaccine trial would be inconvenient or disrupt their daily activities. Conclusions/Significance: Even in rural, resource-limited populations, educational tools can be specially designed that significantly improve understanding and therefore the likelihood of obtaining truly informed consent for participation in clinical research. The observed changes in the knowledge and perceptions of the research participants about hookworm infection and the experimental hookworm vaccine demonstrate that the video intervention was successful in increasing understanding and that the subjects acquired knowledge pertinent to the planned research.Health EducationClinical Trialsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL48.2010.pdf48.2010.pdfapplication/pdf316999https://www.arca.fiocruz.br/bitstream/icict/5615/1/48.2010.pdf4d648611244e82a11131a86b8dfbbf2eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5615/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXT48.2010.pdf.txt48.2010.pdf.txtExtracted texttext/plain59085https://www.arca.fiocruz.br/bitstream/icict/5615/5/48.2010.pdf.txtbe2eafbde997cf7986c10bff053876d5MD55THUMBNAIL48.2010.pdf.jpg48.2010.pdf.jpgGenerated Thumbnailimage/jpeg2701https://www.arca.fiocruz.br/bitstream/icict/5615/4/48.2010.pdf.jpgf21196b08c25fdddfca23b5c8a7d7469MD54icict/56152018-05-02 20:06:48.07oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-05-02T23:06:48Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Health Education through Analogies: Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazil
title Health Education through Analogies: Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazil
spellingShingle Health Education through Analogies: Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazil
Gazzinelli, Maria Flavia
Health Education
Clinical Trials
title_short Health Education through Analogies: Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazil
title_full Health Education through Analogies: Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazil
title_fullStr Health Education through Analogies: Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazil
title_full_unstemmed Health Education through Analogies: Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazil
title_sort Health Education through Analogies: Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazil
author Gazzinelli, Maria Flavia
author_facet Gazzinelli, Maria Flavia
Lobato, Lucas
Matoso, Leonardo Ferreira
Avila, Renato
Marques, Rita de Cassia
Brown, Ami Shah
Oliveira, Rodrigo Corrêa de
Bethony, Jeffrey Michael
Diemert, David J.
author_role author
author2 Lobato, Lucas
Matoso, Leonardo Ferreira
Avila, Renato
Marques, Rita de Cassia
Brown, Ami Shah
Oliveira, Rodrigo Corrêa de
Bethony, Jeffrey Michael
Diemert, David J.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gazzinelli, Maria Flavia
Lobato, Lucas
Matoso, Leonardo Ferreira
Avila, Renato
Marques, Rita de Cassia
Brown, Ami Shah
Oliveira, Rodrigo Corrêa de
Bethony, Jeffrey Michael
Diemert, David J.
dc.subject.en.pt_BR.fl_str_mv Health Education
Clinical Trials
topic Health Education
Clinical Trials
description Universidade Federal de Minas Gerais. Faculdade de Enfermagem. Belo Horizonte, MG, Brazil.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2012-09-28T15:00:30Z
dc.date.available.fl_str_mv 2012-09-28T15:00:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv GAZZINELLI, Maria Flavia et al. Health Education through Analogies: Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazil. PLoS Negl .Trop. Dis., v. 4, n. 7, p. 1-12, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5615
dc.identifier.issn.none.fl_str_mv 19352727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0000749
identifier_str_mv GAZZINELLI, Maria Flavia et al. Health Education through Analogies: Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazil. PLoS Negl .Trop. Dis., v. 4, n. 7, p. 1-12, 2010.
19352727
10.1371/journal.pntd.0000749
url https://www.arca.fiocruz.br/handle/icict/5615
dc.language.iso.fl_str_mv eng
language eng
dc.relation.isbasedon.pt_BR.fl_str_mv Gazzinelli MF, Lobato L, Matoso L, Avila R, de Cassia Marques R, et al. (2010) Health Education through Analogies: Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazil. PLoS Negl Trop Dis 4(7): e749
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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