Mesoionic compounds with antifungal activity against Fusarium verticillioides
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/11496 |
Resumo: | Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil. |
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Paiva, Rojane de OliveiraKneipp, Lucimar FerreiraReis, Camila Moretto dosEchevarria, Aurea2015-08-19T13:49:22Z2015-08-19T13:49:22Z2015PAIVA, Rojane de Oliveira: et al. Mesoionic compounds with antifungal activity against Fusarium verticillioides. BMC Microbiology, v.15:11, 8p, 2015.1471-2180https://www.arca.fiocruz.br/handle/icict/1149610.1186/s12866-015-0340-9engBioMed CentralMesoionic compounds with antifungal activity against Fusarium verticillioidesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.Background: Fungi contaminate the food of humans and animals, are a risk to health, and can cause financial losses. In this work, the antifungal activities of 16 mesoionic compounds (MI 1–16) were evaluated against mycotoxigenic fungi, including Aspergillus spp., Fusarium verticillioides and Penicillium citrinum. Furthermore, the decreased ergosterol in the total lipid content of Fusarium verticillioides was investigated. Results: F. verticillioides was the most sensitive fungus to the mesoionic compounds. Among the evaluated compounds, MI-11 and MI-16 presented higher antifungal effects against F. verticillioides, with MIC values of 7.8 μg/ml, and MI-2 and MI-3 followed, with MICs of 15.6 μg/ml. The most active compounds were those with heterocyclic ring phenyl groups substituted by electron donor moieties (MI-11 and MI-16). Among some compounds with higher activity (MI-2, MI-11 and MI-16), decreased ergosterol content in the total lipid fraction of F. verticillioides was demonstrated. MI-2 reduced the ergosterol content approximately 40% and 80% at concentrations of 7.8 μg/ml and 15.6 μg/ml, respectively, and MI-11 and MI-16 decreased the content by 30% and 50%, respectively, when at a concentration of 7.8 μg/ml. Conclusion: These findings indicate that mesoionic compounds have significant antifungal activity against F. verticillioides.Mycotoxigenic fungiMycotoxicologyMesoionicAntifungal activityErgosterolErgosterolMicotoxinasAntifúngicosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11496/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALrojane_paiva_etal_IOC_2015.pdfapplication/pdf631223https://www.arca.fiocruz.br/bitstream/icict/11496/2/rojane_paiva_etal_IOC_2015.pdff314e4b6c94c272cb5ffd3cc30ffb3e3MD52TEXTrojane_paiva_etal_IOC_2015.pdf.txtrojane_paiva_etal_IOC_2015.pdf.txtExtracted texttext/plain34771https://www.arca.fiocruz.br/bitstream/icict/11496/3/rojane_paiva_etal_IOC_2015.pdf.txt6d9ae6e064ad8e1df12b377288148debMD53icict/114962022-06-24 13:08:58.001oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:08:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Mesoionic compounds with antifungal activity against Fusarium verticillioides |
title |
Mesoionic compounds with antifungal activity against Fusarium verticillioides |
spellingShingle |
Mesoionic compounds with antifungal activity against Fusarium verticillioides Paiva, Rojane de Oliveira Mycotoxigenic fungi Mycotoxicology Mesoionic Antifungal activity Ergosterol Ergosterol Micotoxinas Antifúngicos |
title_short |
Mesoionic compounds with antifungal activity against Fusarium verticillioides |
title_full |
Mesoionic compounds with antifungal activity against Fusarium verticillioides |
title_fullStr |
Mesoionic compounds with antifungal activity against Fusarium verticillioides |
title_full_unstemmed |
Mesoionic compounds with antifungal activity against Fusarium verticillioides |
title_sort |
Mesoionic compounds with antifungal activity against Fusarium verticillioides |
author |
Paiva, Rojane de Oliveira |
author_facet |
Paiva, Rojane de Oliveira Kneipp, Lucimar Ferreira Reis, Camila Moretto dos Echevarria, Aurea |
author_role |
author |
author2 |
Kneipp, Lucimar Ferreira Reis, Camila Moretto dos Echevarria, Aurea |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Paiva, Rojane de Oliveira Kneipp, Lucimar Ferreira Reis, Camila Moretto dos Echevarria, Aurea |
dc.subject.en.pt_BR.fl_str_mv |
Mycotoxigenic fungi Mycotoxicology Mesoionic Antifungal activity Ergosterol |
topic |
Mycotoxigenic fungi Mycotoxicology Mesoionic Antifungal activity Ergosterol Ergosterol Micotoxinas Antifúngicos |
dc.subject.decs.pt_BR.fl_str_mv |
Ergosterol Micotoxinas Antifúngicos |
description |
Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil. |
publishDate |
2015 |
dc.date.accessioned.fl_str_mv |
2015-08-19T13:49:22Z |
dc.date.available.fl_str_mv |
2015-08-19T13:49:22Z |
dc.date.issued.fl_str_mv |
2015 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PAIVA, Rojane de Oliveira: et al. Mesoionic compounds with antifungal activity against Fusarium verticillioides. BMC Microbiology, v.15:11, 8p, 2015. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/11496 |
dc.identifier.issn.pt_BR.fl_str_mv |
1471-2180 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1186/s12866-015-0340-9 |
identifier_str_mv |
PAIVA, Rojane de Oliveira: et al. Mesoionic compounds with antifungal activity against Fusarium verticillioides. BMC Microbiology, v.15:11, 8p, 2015. 1471-2180 10.1186/s12866-015-0340-9 |
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https://www.arca.fiocruz.br/handle/icict/11496 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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BioMed Central |
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BioMed Central |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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