A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014−2018)
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/47799 |
Resumo: | FAPERJ (research support foundation of Rio de Janeiro) |
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Aguiar, Daniele Fernandes deBarros, Eliana Nogueira C. deRibeiro, Guilherme de SousaBrasil, PatriciaMourao, Maria Paula GomesLuz, KleberAoki, Francisco HideoFreitas, Andre Ricardo RibasCalvet, Guilherme AmaralOliveira, EduardoBranco, Bianca F.Abreu, ArianeCheuvart, BrigitteGuignard, AdrienneBoer, Melanie deDuarte, Ana ClaudiaBorges, Maria BeatrizNoronha, Tatiana Guimarães de2021-06-21T16:41:57Z2021-06-21T16:41:57Z2021AGUIAR, Daniele Fernandes de et al. A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014−2018). International Journal of Infectious Diseases, p. 1-47, 2021.1201-9712https://www.arca.fiocruz.br/handle/icict/4779910.1016/j.ijid.2021.04.062FAPERJ (research support foundation of Rio de Janeiro)GSK group of companiesFaculdade de Medicina São Leopoldo MandicBio-Manguinhos / FiocruzFundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.GlaxoSmithKline Brasil. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Amazonas. Boca do Acre, AM, Brasil.Centro de Pesquisas Clínicas de Natal. Natal, RN, Brasil.Universidade Estadual de Campinas. Campinas, SP, Brasil.Faculdade de Medicina e Odontologia São Leopoldo Mandic. Campinas, SP, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.GlaxoSmithKline Brasil. Rio de Janeiro, RJ, Brasil.GlaxoSmithKline Brasil. Rio de Janeiro, RJ, Brasil.GlaxoSmithKline Brasil. Rio de Janeiro, RJ, Brasil.GlaxoSmithKline Belgium. Wavre, Belgium.GlaxoSmithKline Belgium. Wavre, Belgium.GlaxoSmithKline United States. Philadelphia, PA, United States.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Objectives: To estimate the incidence of dengue infection across geographically distinct areas of Brazil. Methods: This prospective, household-based, cohort study enrolled participants in five areas and followed them up for up to 4 years (2014−2018). Dengue seroprevalence was assessed at each scheduled visit. Suspected dengue cases were identified through enhanced passive and active surveillance. Acute symptomatic dengue infection was confirmed through reverse-transcriptase quantitative polymerase chain reaction in combination with an antigenic assay (NS1) and serology. Results: Among 3300 participants enrolled, baseline seroprevalence was 76.2%, although only 23.3% of participants reported a history of dengue. Of 1284 suspected symptomatic dengue cases detected, 50 (3.9%) were laboratory-confirmed. Based on 8166.5 person-years (PY) of follow-up, the incidence of laboratory-confirmed symptomatic infection (primary endpoint) was 6.1 per 1000 PY (95% confidence interval [CI]: 4.5, 8.1). Incidence varied substantially in different years (1.8−7.4 per 1000 PY). The incidence of inapparent primary dengue infection was substantially higher: 41.7 per 1000 PY (95% CI: 31.1, 54.6). Conclusions: Our findings, highlighting that the incidence of dengue infection is underestimated in Brazil, will inform the design and implementation of future dengue vaccine trials.engElsevierDengueIncidênciaSoroprevalênciaEpidemiologiaEstudo de coorte multicêntricoBrasilDengueIncidenceSeroprevalenceEpidemiologyMulticentre cohort studyBrazilReação em Cadeia da PolimeraseA prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014−2018)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/47799/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALAguiar Daniele fernandes A prospective....pdfAguiar Daniele fernandes A 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| dc.title.en.fl_str_mv |
A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014−2018) |
| title |
A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014−2018) |
| spellingShingle |
A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014−2018) Aguiar, Daniele Fernandes de Dengue Incidência Soroprevalência Epidemiologia Estudo de coorte multicêntrico Brasil Dengue Incidence Seroprevalence Epidemiology Multicentre cohort study Brazil Reação em Cadeia da Polimerase |
| title_short |
A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014−2018) |
| title_full |
A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014−2018) |
| title_fullStr |
A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014−2018) |
| title_full_unstemmed |
A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014−2018) |
| title_sort |
A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014−2018) |
| author |
Aguiar, Daniele Fernandes de |
| author_facet |
Aguiar, Daniele Fernandes de Barros, Eliana Nogueira C. de Ribeiro, Guilherme de Sousa Brasil, Patricia Mourao, Maria Paula Gomes Luz, Kleber Aoki, Francisco Hideo Freitas, Andre Ricardo Ribas Calvet, Guilherme Amaral Oliveira, Eduardo Branco, Bianca F. Abreu, Ariane Cheuvart, Brigitte Guignard, Adrienne Boer, Melanie de Duarte, Ana Claudia Borges, Maria Beatriz Noronha, Tatiana Guimarães de |
| author_role |
author |
| author2 |
Barros, Eliana Nogueira C. de Ribeiro, Guilherme de Sousa Brasil, Patricia Mourao, Maria Paula Gomes Luz, Kleber Aoki, Francisco Hideo Freitas, Andre Ricardo Ribas Calvet, Guilherme Amaral Oliveira, Eduardo Branco, Bianca F. Abreu, Ariane Cheuvart, Brigitte Guignard, Adrienne Boer, Melanie de Duarte, Ana Claudia Borges, Maria Beatriz Noronha, Tatiana Guimarães de |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Aguiar, Daniele Fernandes de Barros, Eliana Nogueira C. de Ribeiro, Guilherme de Sousa Brasil, Patricia Mourao, Maria Paula Gomes Luz, Kleber Aoki, Francisco Hideo Freitas, Andre Ricardo Ribas Calvet, Guilherme Amaral Oliveira, Eduardo Branco, Bianca F. Abreu, Ariane Cheuvart, Brigitte Guignard, Adrienne Boer, Melanie de Duarte, Ana Claudia Borges, Maria Beatriz Noronha, Tatiana Guimarães de |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue Incidência Soroprevalência Epidemiologia Estudo de coorte multicêntrico Brasil |
| topic |
Dengue Incidência Soroprevalência Epidemiologia Estudo de coorte multicêntrico Brasil Dengue Incidence Seroprevalence Epidemiology Multicentre cohort study Brazil Reação em Cadeia da Polimerase |
| dc.subject.en.en.fl_str_mv |
Dengue Incidence Seroprevalence Epidemiology Multicentre cohort study Brazil |
| dc.subject.decs.pt_BR.fl_str_mv |
Reação em Cadeia da Polimerase |
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FAPERJ (research support foundation of Rio de Janeiro) |
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2021 |
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2021-06-21T16:41:57Z |
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2021-06-21T16:41:57Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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AGUIAR, Daniele Fernandes de et al. A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014−2018). International Journal of Infectious Diseases, p. 1-47, 2021. |
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https://www.arca.fiocruz.br/handle/icict/47799 |
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1201-9712 |
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10.1016/j.ijid.2021.04.062 |
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AGUIAR, Daniele Fernandes de et al. A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014−2018). International Journal of Infectious Diseases, p. 1-47, 2021. 1201-9712 10.1016/j.ijid.2021.04.062 |
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Elsevier |
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Elsevier |
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