Landmarks of the Knowledge and Trypanosoma cruzi Biology in the Wild Environment

Detalhes bibliográficos
Autor(a) principal: Jansen, Ana Maria
Data de Publicação: 2020
Outros Autores: Xavier, Samanta Cristina das Chagas, Roque, André Luiz R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40561
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
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spelling Jansen, Ana MariaXavier, Samanta Cristina das ChagasRoque, André Luiz R.2020-03-30T19:16:43Z2020-03-30T19:16:43Z2020JANSEN, Ana Maria; XAVIER, Samanta Cristina das Chagas; ROQUE, André Luiz Rodrigues. Trypanosoma cruzi of the knowledge and Trypanosoma cruz biology in the wild environment. Frontiers in Cellular and Infection Microbiology, v. 10, Article 10, p. 1-15, Feb. 2020.2235-2988https://www.arca.fiocruz.br/handle/icict/4056110.3389/fcimb.2020.00010engFrontiers MediaTrypanosoma cruziAnálise espacialMamíferos selvagensCiclo de transmissãoReservatóriosTrypanosomatidsTrypanosoma cruziWild mammalsTransmission cycleReservoirsSpatial analysisLandmarks of the Knowledge and Trypanosoma cruzi Biology in the Wild Environmentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Trypanosomatids are ancient parasitic eukaryotes that still maintain prokaryotic characteristics. Trypanosoma cruzi, a primarily wild mammal parasite, infected humans already long before European colonization of the Americas. T. cruzi heterogeneity remains an unsolved question, and until now, it has still not been possible to associate T. cruzi genotypes with any biological or epidemiological feature. One of the first biochemical attempts to cluster the T. cruzi subpopulations recognized three main subpopulations (zymodemes) that have been associated with the transmission cycles in the wild (Z1; Z3) and in the domestic environment (Z2). The description of wild mammal species harboring Z2 two decades later challenged this assemblage attempt. Currently, the genotypes of T. cruzi are assembled in seven discrete typing units (DTUs). The biology of T. cruzi still shows novelties such as the description of epimastigotes multiplying and differentiating to metacyclic trypomastigotes in the lumen of the scent glands of Didelphis spp. and the capacity of the true meiosis in parallel to clonal reproduction. The study of the transmission cycle among wild animals has broken paradigms and raised new questions: (i) the interaction of the T. cruzi DTUs with each of its mammalian host species displays peculiarities; (ii) the impact of mixed genotypes and species on the transmissibility of one or another species or on pathogenesis is still unknown; (iii) independent T. cruzi transmission cycles may occur in the same forest fragment; (iv) the capacity to act as a reservoir depends on the peculiarities of the host species and the parasite genotype; and (v) faunistic composition is a defining trait of the T. cruzi transmission cycle profile. The development of models of environmental variables that determine the spatial distribution of the elements that make up T. cruzi transmission by spatial analysis, followed by map algebra and networking, are the next steps toward interpreting and dealing with the new profile of Chagas disease with its many peculiarities. There is no way to solve this neglected disease once and for all if not through a multidisciplinary look that takes into account all kinds of human and animal activities in parallel to environmental variations.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40561/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAnaMAriaJansen_AndreLRoque_etal_IOC_2020.pdfAnaMAriaJansen_AndreLRoque_etal_IOC_2020.pdfapplication/pdf1519459https://www.arca.fiocruz.br/bitstream/icict/40561/2/AnaMAriaJansen_AndreLRoque_etal_IOC_2020.pdfb0279e81196ceb842818b7597390d916MD52TEXTAnaMAriaJansen_AndreLRoque_etal_IOC_2020.pdf.txtAnaMAriaJansen_AndreLRoque_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Landmarks of the Knowledge and Trypanosoma cruzi Biology in the Wild Environment
title Landmarks of the Knowledge and Trypanosoma cruzi Biology in the Wild Environment
spellingShingle Landmarks of the Knowledge and Trypanosoma cruzi Biology in the Wild Environment
Jansen, Ana Maria
Trypanosoma cruzi
Análise espacial
Mamíferos selvagens
Ciclo de transmissão
Reservatórios
Trypanosomatids
Trypanosoma cruzi
Wild mammals
Transmission cycle
Reservoirs
Spatial analysis
title_short Landmarks of the Knowledge and Trypanosoma cruzi Biology in the Wild Environment
title_full Landmarks of the Knowledge and Trypanosoma cruzi Biology in the Wild Environment
title_fullStr Landmarks of the Knowledge and Trypanosoma cruzi Biology in the Wild Environment
title_full_unstemmed Landmarks of the Knowledge and Trypanosoma cruzi Biology in the Wild Environment
title_sort Landmarks of the Knowledge and Trypanosoma cruzi Biology in the Wild Environment
author Jansen, Ana Maria
author_facet Jansen, Ana Maria
Xavier, Samanta Cristina das Chagas
Roque, André Luiz R.
author_role author
author2 Xavier, Samanta Cristina das Chagas
Roque, André Luiz R.
author2_role author
author
dc.contributor.author.fl_str_mv Jansen, Ana Maria
Xavier, Samanta Cristina das Chagas
Roque, André Luiz R.
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Análise espacial
Mamíferos selvagens
Ciclo de transmissão
Reservatórios
topic Trypanosoma cruzi
Análise espacial
Mamíferos selvagens
Ciclo de transmissão
Reservatórios
Trypanosomatids
Trypanosoma cruzi
Wild mammals
Transmission cycle
Reservoirs
Spatial analysis
dc.subject.en.pt_BR.fl_str_mv Trypanosomatids
Trypanosoma cruzi
Wild mammals
Transmission cycle
Reservoirs
Spatial analysis
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-03-30T19:16:43Z
dc.date.available.fl_str_mv 2020-03-30T19:16:43Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv JANSEN, Ana Maria; XAVIER, Samanta Cristina das Chagas; ROQUE, André Luiz Rodrigues. Trypanosoma cruzi of the knowledge and Trypanosoma cruz biology in the wild environment. Frontiers in Cellular and Infection Microbiology, v. 10, Article 10, p. 1-15, Feb. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40561
dc.identifier.issn.pt_BR.fl_str_mv 2235-2988
dc.identifier.doi.none.fl_str_mv 10.3389/fcimb.2020.00010
identifier_str_mv JANSEN, Ana Maria; XAVIER, Samanta Cristina das Chagas; ROQUE, André Luiz Rodrigues. Trypanosoma cruzi of the knowledge and Trypanosoma cruz biology in the wild environment. Frontiers in Cellular and Infection Microbiology, v. 10, Article 10, p. 1-15, Feb. 2020.
2235-2988
10.3389/fcimb.2020.00010
url https://www.arca.fiocruz.br/handle/icict/40561
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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