Efficacy of brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: a randomized, controlled clinical trial
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/48779 |
Resumo: | Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
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Silveira, Marcelo Augusto DuarteJong, David deBerretta, Andresa AparecidaGalvão, Erica Batista dos SantosRibeiro, Juliana CaldasSilva, Thiago CerqueiraAmorim, Thais ChavesConceição, Luis Filipe Miranda Rebelo daGomes, Marcel Miranda DantasTeixeira, Maurício BritoSouza, Sergio Pinto deSantos, Marcele Helena Celestino Alves dosMartin, Raissa Lanna Araújo SanSilva, Márcio de OliveiraLírio, MoniqueMoreno, LisSampaio, Julio Cezar MirandaMendonça, RenataUltchak, Silviana SallesAmorim, Fabio SantosRamos, João Gabriel RosaBatista, Paulo Benigno PenaGuarda, Suzete Nascimento Farias daMendes, Ana Verena AlmeidaPassos, Rogerio da Hora2021-08-27T17:15:30Z2021-08-27T17:15:30Z2021SILVEIRA, Marcelo Augusto Duarte et al. Efficacy of brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: a randomized, controlled clinical trial. Biomedicine and Pharmacotherapy, v. 138, n. 111526, p. 1-10, 20 Mar. 2021.0753-3322https://www.arca.fiocruz.br/handle/icict/4877910.1016/j.biopha.2021.111526Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.D’Or Institute for Research and Education (IDOR), BrazilApis Flora Indl. Coml. Ltda., BrazilInstituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto, SP, Brasil.Apis Flora Industrial e Comercial Ltda. Divisão Industrial de Pesquisa, Desenvolvimento e Inovação. Ribeirão Preto, SP, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil / Universidade Salvador. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade do Estado da Bahia. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Instituto D'Or de Ensino e Pesquisa. Hospital São Rafael. Salvador, BA, Brasil.Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) promotes challenging immune and inflammatory phenomena. Though various therapeutic possibilities have been tested against coronavirus disease 2019 (COVID-19), the most adequate treatment has not yet been established. Propolis is a natural product with considerable evidence of immunoregulatory and anti-inflammatory activities, and experimental data point to potential against viral targets. We hypothesized that propolis can reduce the negative effects of COVID-19. Methods: In a randomized, controlled, open-label, single-center trial, hospitalized adult COVID-19 patients were treated with a standardized green propolis extract (EPP-AF® of acute kidney injury than in the controls (4.8 vs 23.8%), (odds ratio [OR] 0.18; 95% CI 0.03–0.84; p =0.048). No patient had propolis treatment discontinued due to adverse events. Conclusions: Addition of propolis to the standard care procedures resulted in clinical benefits for the hospitalized COVID-19 patients, especially evidenced by a reduction in the length of hospital stay. Consequently, we conclude that propolis can reduce the impact of COVID-19.engElsevierPrópoleSARS-CoV-2ImunoregulaçãoAgentes anti-inflamatóriosCoronavirusCOVID-19PropolisAnti-inflammatory agentsImmunoregulationACE2PAK1 blockerTMPRSS2COVID-19Efficacy of brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: a randomized, controlled clinical trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/48779/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALSilveira, Marcelo Augusto Duarte Efficacy of ....pdfSilveira, Marcelo Augusto Duarte Efficacy of 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| dc.title.en.fl_str_mv |
Efficacy of brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: a randomized, controlled clinical trial |
| title |
Efficacy of brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: a randomized, controlled clinical trial |
| spellingShingle |
Efficacy of brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: a randomized, controlled clinical trial Silveira, Marcelo Augusto Duarte Própole SARS-CoV-2 Imunoregulação Agentes anti-inflamatórios Coronavirus COVID-19 Propolis Anti-inflammatory agents Immunoregulation ACE2 PAK1 blocker TMPRSS2 COVID-19 |
| title_short |
Efficacy of brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: a randomized, controlled clinical trial |
| title_full |
Efficacy of brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: a randomized, controlled clinical trial |
| title_fullStr |
Efficacy of brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: a randomized, controlled clinical trial |
| title_full_unstemmed |
Efficacy of brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: a randomized, controlled clinical trial |
| title_sort |
Efficacy of brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: a randomized, controlled clinical trial |
| author |
Silveira, Marcelo Augusto Duarte |
| author_facet |
Silveira, Marcelo Augusto Duarte Jong, David de Berretta, Andresa Aparecida Galvão, Erica Batista dos Santos Ribeiro, Juliana Caldas Silva, Thiago Cerqueira Amorim, Thais Chaves Conceição, Luis Filipe Miranda Rebelo da Gomes, Marcel Miranda Dantas Teixeira, Maurício Brito Souza, Sergio Pinto de Santos, Marcele Helena Celestino Alves dos Martin, Raissa Lanna Araújo San Silva, Márcio de Oliveira Lírio, Monique Moreno, Lis Sampaio, Julio Cezar Miranda Mendonça, Renata Ultchak, Silviana Salles Amorim, Fabio Santos Ramos, João Gabriel Rosa Batista, Paulo Benigno Pena Guarda, Suzete Nascimento Farias da Mendes, Ana Verena Almeida Passos, Rogerio da Hora |
| author_role |
author |
| author2 |
Jong, David de Berretta, Andresa Aparecida Galvão, Erica Batista dos Santos Ribeiro, Juliana Caldas Silva, Thiago Cerqueira Amorim, Thais Chaves Conceição, Luis Filipe Miranda Rebelo da Gomes, Marcel Miranda Dantas Teixeira, Maurício Brito Souza, Sergio Pinto de Santos, Marcele Helena Celestino Alves dos Martin, Raissa Lanna Araújo San Silva, Márcio de Oliveira Lírio, Monique Moreno, Lis Sampaio, Julio Cezar Miranda Mendonça, Renata Ultchak, Silviana Salles Amorim, Fabio Santos Ramos, João Gabriel Rosa Batista, Paulo Benigno Pena Guarda, Suzete Nascimento Farias da Mendes, Ana Verena Almeida Passos, Rogerio da Hora |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silveira, Marcelo Augusto Duarte Jong, David de Berretta, Andresa Aparecida Galvão, Erica Batista dos Santos Ribeiro, Juliana Caldas Silva, Thiago Cerqueira Amorim, Thais Chaves Conceição, Luis Filipe Miranda Rebelo da Gomes, Marcel Miranda Dantas Teixeira, Maurício Brito Souza, Sergio Pinto de Santos, Marcele Helena Celestino Alves dos Martin, Raissa Lanna Araújo San Silva, Márcio de Oliveira Lírio, Monique Moreno, Lis Sampaio, Julio Cezar Miranda Mendonça, Renata Ultchak, Silviana Salles Amorim, Fabio Santos Ramos, João Gabriel Rosa Batista, Paulo Benigno Pena Guarda, Suzete Nascimento Farias da Mendes, Ana Verena Almeida Passos, Rogerio da Hora |
| dc.subject.other.pt_BR.fl_str_mv |
Própole SARS-CoV-2 Imunoregulação Agentes anti-inflamatórios Coronavirus COVID-19 |
| topic |
Própole SARS-CoV-2 Imunoregulação Agentes anti-inflamatórios Coronavirus COVID-19 Propolis Anti-inflammatory agents Immunoregulation ACE2 PAK1 blocker TMPRSS2 COVID-19 |
| dc.subject.en.en.fl_str_mv |
Propolis Anti-inflammatory agents Immunoregulation ACE2 PAK1 blocker TMPRSS2 |
| dc.subject.en.pt_BR.fl_str_mv |
COVID-19 |
| description |
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
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2021 |
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2021-08-27T17:15:30Z |
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2021-08-27T17:15:30Z |
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2021 |
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info:eu-repo/semantics/article |
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SILVEIRA, Marcelo Augusto Duarte et al. Efficacy of brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: a randomized, controlled clinical trial. Biomedicine and Pharmacotherapy, v. 138, n. 111526, p. 1-10, 20 Mar. 2021. |
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https://www.arca.fiocruz.br/handle/icict/48779 |
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0753-3322 |
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10.1016/j.biopha.2021.111526 |
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SILVEIRA, Marcelo Augusto Duarte et al. Efficacy of brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: a randomized, controlled clinical trial. Biomedicine and Pharmacotherapy, v. 138, n. 111526, p. 1-10, 20 Mar. 2021. 0753-3322 10.1016/j.biopha.2021.111526 |
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MD5 MD5 MD5 MD5 |
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Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
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repositorio.arca@fiocruz.br |
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1813009283770482688 |