First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil

Detalhes bibliográficos
Autor(a) principal: Oliveira, Rômulo Vieira Mello de
Data de Publicação: 2023
Outros Autores: Corrêa-Moreira, Danielly, Mendes, Túlio Vieira, Costa, Gisela Lara da, Vieira, Renata de Magalhães, Buchele, Cynthia Miranda Nascimento, Lins, Rodrigo Schrage, Ferreira, Ana Beatriz Teixeira Brandão Camello, Veira, Daniela Barbosa, Pedroso, Rafael Santos de Aragão, Faria, Vinícius Tadeu Dias Pereira de, Oliveira, Manoel Marques Evangelista
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56345
Resumo: Hospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
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spelling Oliveira, Rômulo Vieira Mello deCorrêa-Moreira, DaniellyMendes, Túlio VieiraCosta, Gisela Lara daVieira, Renata de MagalhãesBuchele, Cynthia Miranda NascimentoLins, Rodrigo SchrageFerreira, Ana Beatriz Teixeira Brandão CamelloVeira, Daniela BarbosaPedroso, Rafael Santos de AragãoFaria, Vinícius Tadeu Dias Pereira deOliveira, Manoel Marques Evangelista2023-01-06T12:41:42Z2023-01-06T12:41:42Z2023OLIVEIRA, Rômulo Vieira Mello de et al. First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil. International Journal of Infectious Diseases, v. 126, p. 94-97, Jan. 2023.1201-9712https://www.arca.fiocruz.br/handle/icict/5634510.1016/j.ijid.2022.11.015engElsevier Open AccessInfeções fungaisPaciente imunocompetenteMeningoencefalitePenicilliumPenicillium chrysogenumFungal infectionsImmunocompetent patientMeningoencephalitisPenicilliumPenicillium chrysogenumFirst report of fungal meningoencephalitis by Penicillium chrysogenum in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Marcilio Dias Naval Hospital. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil.Hospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Hospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Hospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Hospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Hospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Hospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Hospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil.Introduction: Fungal infections of the central nervous system present a variety of clinical syndromes, such as meningitis, encephalitis, raised intracranial pressure with a nonspecific presentation, and, in the last two decades, have increased the incidence of these fungal infections. Fungal meningoencephalitis is frequently associated with Cryptococcus, but this report stands out for presenting one species of Penicillium genus. Objectives: Here, we present the first case of meningoencephalitis associated with brain injury caused by Penicillium chrysogenum, in a patient who is immunocompetent and was admitted to Hospital Naval Marcílio Dias, Rio de Janeiro, Brazil. Methods: To identify the fungal species, we performed phenotypic and genotypic methodologies, from the culture to the sequencing of internal transcribed spacer region, and β-tubulin gene, a rare fungus in cerebrospinal fluid cultures, belonging to the genus Penicillium, was identified. Conclusion: We highlight the importance of the first report of meningoencephalitis caused by P. chrysogenum in a patient who is immunocompetent, registered in Brazil. We also emphasize the need for further studies to determine an effective treatment with the least possible side effects for patients infected by fungi that are rarely related to the most severe forms of invasive infections.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56345/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOliveira_Rômulo_etal_IOC_2023.pdfOliveira_Rômulo_etal_IOC_2023.pdfapplication/pdf876166https://www.arca.fiocruz.br/bitstream/icict/56345/2/Oliveira_R%c3%b4mulo_etal_IOC_2023.pdf0d5dedaa5561fc34afa6dcf008910638MD52icict/563452023-09-04 11:10:29.946oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:10:29Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.en_US.fl_str_mv First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil
title First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil
spellingShingle First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil
Oliveira, Rômulo Vieira Mello de
Infeções fungais
Paciente imunocompetente
Meningoencefalite
Penicillium
Penicillium chrysogenum
Fungal infections
Immunocompetent patient
Meningoencephalitis
Penicillium
Penicillium chrysogenum
title_short First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil
title_full First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil
title_fullStr First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil
title_full_unstemmed First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil
title_sort First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil
author Oliveira, Rômulo Vieira Mello de
author_facet Oliveira, Rômulo Vieira Mello de
Corrêa-Moreira, Danielly
Mendes, Túlio Vieira
Costa, Gisela Lara da
Vieira, Renata de Magalhães
Buchele, Cynthia Miranda Nascimento
Lins, Rodrigo Schrage
Ferreira, Ana Beatriz Teixeira Brandão Camello
Veira, Daniela Barbosa
Pedroso, Rafael Santos de Aragão
Faria, Vinícius Tadeu Dias Pereira de
Oliveira, Manoel Marques Evangelista
author_role author
author2 Corrêa-Moreira, Danielly
Mendes, Túlio Vieira
Costa, Gisela Lara da
Vieira, Renata de Magalhães
Buchele, Cynthia Miranda Nascimento
Lins, Rodrigo Schrage
Ferreira, Ana Beatriz Teixeira Brandão Camello
Veira, Daniela Barbosa
Pedroso, Rafael Santos de Aragão
Faria, Vinícius Tadeu Dias Pereira de
Oliveira, Manoel Marques Evangelista
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Rômulo Vieira Mello de
Corrêa-Moreira, Danielly
Mendes, Túlio Vieira
Costa, Gisela Lara da
Vieira, Renata de Magalhães
Buchele, Cynthia Miranda Nascimento
Lins, Rodrigo Schrage
Ferreira, Ana Beatriz Teixeira Brandão Camello
Veira, Daniela Barbosa
Pedroso, Rafael Santos de Aragão
Faria, Vinícius Tadeu Dias Pereira de
Oliveira, Manoel Marques Evangelista
dc.subject.other.en_US.fl_str_mv Infeções fungais
Paciente imunocompetente
Meningoencefalite
Penicillium
Penicillium chrysogenum
topic Infeções fungais
Paciente imunocompetente
Meningoencefalite
Penicillium
Penicillium chrysogenum
Fungal infections
Immunocompetent patient
Meningoencephalitis
Penicillium
Penicillium chrysogenum
dc.subject.en.en_US.fl_str_mv Fungal infections
Immunocompetent patient
Meningoencephalitis
Penicillium
Penicillium chrysogenum
description Hospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-01-06T12:41:42Z
dc.date.available.fl_str_mv 2023-01-06T12:41:42Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Rômulo Vieira Mello de et al. First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil. International Journal of Infectious Diseases, v. 126, p. 94-97, Jan. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56345
dc.identifier.issn.en_US.fl_str_mv 1201-9712
dc.identifier.doi.none.fl_str_mv 10.1016/j.ijid.2022.11.015
identifier_str_mv OLIVEIRA, Rômulo Vieira Mello de et al. First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil. International Journal of Infectious Diseases, v. 126, p. 94-97, Jan. 2023.
1201-9712
10.1016/j.ijid.2022.11.015
url https://www.arca.fiocruz.br/handle/icict/56345
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier Open Access
publisher.none.fl_str_mv Elsevier Open Access
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56345/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56345/2/Oliveira_R%c3%b4mulo_etal_IOC_2023.pdf
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