Prevalence of Café-au-Lait Spots in children with solid tumors

Detalhes bibliográficos
Autor(a) principal: Santos, Anna Claudia Evangelista dos
Data de Publicação: 2016
Outros Autores: Heck, Benjamin, Camargo, Beatriz de, Vargas, Fernando Regla
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16576
Resumo: Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Departamento de Genética e Biologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro (UFRJ). Departamento de Genética. Rio de Janeiro, RJ, Brasil.
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spelling Santos, Anna Claudia Evangelista dosHeck, BenjaminCamargo, Beatriz deVargas, Fernando Regla2016-12-27T14:04:10Z2016-12-27T14:04:10Z2016SANTOS, Anna Claudia Evangelista dos; et al. Prevalence of Café-au-Lait Spots in children with solid tumors. Genetics and Molecular Biology, v.39, n.2, p.232-238, 2016.1415-4757https://www.arca.fiocruz.br/handle/icict/1657610.1590/1678-4685-GMB-2015-00241678-4685engSociedade Brasileira de GenéticaAnormalidades CongênitasTumores sólidos pediátricosNosologiacafé-au-lait maculaepediatric solid tumorsbirth defectsnosologyPrevalence of Café-au-Lait Spots in children with solid tumorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Estado do Rio de Janeiro (UNIRIO). Departamento de Genética e Biologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro (UFRJ). Departamento de Genética. Rio de Janeiro, RJ, Brasil.AC Camargo Cancer Center. Departamento de Pediatria. São Paulo, SP, Brasil.AC Camargo Cancer Center. Departamento de Pediatria. São Paulo, SP, Brasil / Instituto Nacional de Câncer. Departamento de Oncologia Pediátrica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Departamento de Genética e Biologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro (UFRJ). Departamento de Genética. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia de Malformações Congênitas. Rio de Janeiro, RJ, Brasil.Cafe-au-lait maculae (CALM) are frequently observed in humans, and usually are present as a solitary spot. Multiple CALMs are present in a smaller fraction of the population and are usually associated with other congenital anomalies as part of many syndromes. Most of these syndromes carry an increased risk of cancer development. Previous studies have indicated that minor congenital anomalies may be more prevalent in children with cancer. We investigated the prevalence of CALMs in two samples of Brazilian patients with childhood solid tumors, totaling 307 individuals. Additionally, 176 school children without diagnosis of cancer, or of a cancer predisposing syndrome, were investigated for the presence of CALMs. The prevalence of solitary CALM was similar in both study groups (18% and 19%) and also in the group of children without cancer. Multiple CALMs were more frequently observed in one of the study groups (Z = 2.1). However, when both groups were analyzed together, the significance disappeared (Z = 1.5). The additional morphological abnormalities in children with multiple CALMs were analyzed and compared to the findings observed in the literature. The nosologic entities associated with CALMs are reviewed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16576/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALfernando_vargas_etal_IOC_2016.pdffernando_vargas_etal_IOC_2016.pdfapplication/pdf459432https://www.arca.fiocruz.br/bitstream/icict/16576/2/fernando_vargas_etal_IOC_2016.pdfb0bf048577d1b06c975434f98847b1a4MD52TEXTfernando_vargas_etal_IOC_2016.pdf.txtfernando_vargas_etal_IOC_2016.pdf.txtExtracted texttext/plain27863https://www.arca.fiocruz.br/bitstream/icict/16576/3/fernando_vargas_etal_IOC_2016.pdf.txtce1736c397f7adbf9ac5720ce53b43c0MD53icict/165762018-08-15 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dc.title.pt_BR.fl_str_mv Prevalence of Café-au-Lait Spots in children with solid tumors
title Prevalence of Café-au-Lait Spots in children with solid tumors
spellingShingle Prevalence of Café-au-Lait Spots in children with solid tumors
Santos, Anna Claudia Evangelista dos
Anormalidades Congênitas
Tumores sólidos pediátricos
Nosologia
café-au-lait maculae
pediatric solid tumors
birth defects
nosology
title_short Prevalence of Café-au-Lait Spots in children with solid tumors
title_full Prevalence of Café-au-Lait Spots in children with solid tumors
title_fullStr Prevalence of Café-au-Lait Spots in children with solid tumors
title_full_unstemmed Prevalence of Café-au-Lait Spots in children with solid tumors
title_sort Prevalence of Café-au-Lait Spots in children with solid tumors
author Santos, Anna Claudia Evangelista dos
author_facet Santos, Anna Claudia Evangelista dos
Heck, Benjamin
Camargo, Beatriz de
Vargas, Fernando Regla
author_role author
author2 Heck, Benjamin
Camargo, Beatriz de
Vargas, Fernando Regla
author2_role author
author
author
dc.contributor.author.fl_str_mv Santos, Anna Claudia Evangelista dos
Heck, Benjamin
Camargo, Beatriz de
Vargas, Fernando Regla
dc.subject.other.pt_BR.fl_str_mv Anormalidades Congênitas
Tumores sólidos pediátricos
Nosologia
topic Anormalidades Congênitas
Tumores sólidos pediátricos
Nosologia
café-au-lait maculae
pediatric solid tumors
birth defects
nosology
dc.subject.en.pt_BR.fl_str_mv café-au-lait maculae
pediatric solid tumors
birth defects
nosology
description Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Departamento de Genética e Biologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro (UFRJ). Departamento de Genética. Rio de Janeiro, RJ, Brasil.
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-12-27T14:04:10Z
dc.date.available.fl_str_mv 2016-12-27T14:04:10Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, Anna Claudia Evangelista dos; et al. Prevalence of Café-au-Lait Spots in children with solid tumors. Genetics and Molecular Biology, v.39, n.2, p.232-238, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16576
dc.identifier.issn.pt_BR.fl_str_mv 1415-4757
dc.identifier.doi.none.fl_str_mv 10.1590/1678-4685-GMB-2015-0024
dc.identifier.eissn.none.fl_str_mv 1678-4685
identifier_str_mv SANTOS, Anna Claudia Evangelista dos; et al. Prevalence of Café-au-Lait Spots in children with solid tumors. Genetics and Molecular Biology, v.39, n.2, p.232-238, 2016.
1415-4757
10.1590/1678-4685-GMB-2015-0024
1678-4685
url https://www.arca.fiocruz.br/handle/icict/16576
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/16576/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/16576/2/fernando_vargas_etal_IOC_2016.pdf
https://www.arca.fiocruz.br/bitstream/icict/16576/3/fernando_vargas_etal_IOC_2016.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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