Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions.
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
DOI: | 10.1155/2014/345659 |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/9584 |
Resumo: | Universidade de São Paulo. Escola de Medicina. Instituto do Coração. Laboratory of Immunology. São Paulo, SP, Brazil |
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Abel, Lúcia Cristina JamliFerreira, Ludmila Rodrigues PintoNavarro, Isabela CunhaBaron, Monique AndradeKalil, JorgeGazzinelli, Ricardo TostesRizzo, Luiz VicenteCunha Neto, Edecio2015-03-02T18:05:44Z2015-03-02T18:05:44Z2014ABEL, Lúcia Cristina Jamli et al. Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions. Mediators of Inflammation, V. 2014, Article ID 345659, 7 p., 20140962-9351https://www.arca.fiocruz.br/handle/icict/958410.1155/2014/345659engHindawi Publishing CorporationInduction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Escola de Medicina. Instituto do Coração. Laboratory of Immunology. São Paulo, SP, BrazilUniversidade de São Paulo. Escola de Medicina. Instituto do Coração. Laboratory of Immunology. São Paulo, SP, Brazil/Universidade de São Paulo. Escola de Medicina. Clinca de Imunologia e Alergia. Sao Paulo, SP, Brazil/Institutos Nacionais de Ciência e Tecnologia. Instituto de Investigação em Imunologia. Sao Paulo, SP, BrazilUniversidade de São Paulo. Escola de Medicina. Instituto do Coração. Laboratory of Immunology. São Paulo, SP, Brazil/Universidade de São Paulo. Escola de Medicina. Clinca de Imunologia e Alergia. Sao Paulo, SP, Brazil/Institutos Nacionais de Ciência e Tecnologia. Instituto de Investigação em Imunologia. Sao Paulo, SP, BrazilUniversidade de São Paulo. Escola de Medicina. Instituto do Coração. Laboratory of Immunology. São Paulo, SP, Brazil/Universidade de São Paulo. Escola de Medicina. Clinca de Imunologia e Alergia. Sao Paulo, SP, Brazil/Institutos Nacionais de Ciência e Tecnologia. Instituto de Investigação em Imunologia. Sao Paulo, SP, BrazilUniversidade de São Paulo. Escola de Medicina. Instituto do Coração. Laboratory of Immunology. São Paulo, SP, Brazil/Universidade de São Paulo. Escola de Medicina. Clinca de Imunologia e Alergia. Sao Paulo, SP, Brazil/Institutos Nacionais de Ciência e Tecnologia. Instituto de Investigação em Imunologia. Sao Paulo, SP, BrazilFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas.Departamento de Bioquimica e Imunologia. Laboratorio de Imunopatologia. Belo Horizonte, MG, Brazil/University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USAHospital Israelita Albert Einstein. Sao Paulo, SP, BrazilUniversidade de São Paulo. Escola de Medicina. Instituto do Coração. Laboratory of Immunology. São Paulo, SP, Brazil/Universidade de São Paulo. Escola de Medicina. Clinca de Imunologia e Alergia. Sao Paulo, SP, Brazil/Institutos Nacionais de Ciência e Tecnologia. Instituto de Investigação em Imunologia. Sao Paulo, SP, BrazilChagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is characterized by immunopathology driven by IFN-γ secreting Th1-like T cells. T. cruzi has a thick coat of mucin-like glycoproteins covering its surface, which plays an important role in parasite invasion and host immunomodulation. It has been extensively described that T. cruzi or its products-like GPI anchors isolated from GPI-anchored mucins from the trypomastigote life cycle stage (tGPI-mucins)-are potent inducers of proinflammatory responses (i.e., cytokines and NO production) by IFN-γ primed murine macrophages. However, little is known about whether T. cruzi or GPI-mucins exert a similar action in human cells. We therefore decided to further investigate the in vitro cytokine production profile from human mononuclear cells from uninfected donors exposed to T. cruzi as well as tGPI-mucins. We observed that both living T. cruzi trypomastigotes and tGPI-mucins are potent inducers of IL-12 by human peripheral blood monocytes and this effect depends on CD40-CD40L interaction and IFN-γ. Our findings suggest that the polarized T1-type cytokine profile seen in T. cruzi infected patients might be a long-term effect of IL-12 production induced by lifelong exposure to T. cruzi tGPI-mucins.Chagas diseaseTrypanosoma cruziinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9584/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINAL2014_132.pdf2014_132.pdfapplication/pdf1484334https://www.arca.fiocruz.br/bitstream/icict/9584/2/2014_132.pdfd096f23e5a1f9d4cd062bfcebc0ee3c2MD52TEXT2014_132.pdf.txt2014_132.pdf.txtExtracted texttext/plain34020https://www.arca.fiocruz.br/bitstream/icict/9584/3/2014_132.pdf.txtef093235de092923e6011051472a1446MD53icict/95842019-06-19 10:07:47.992oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:07:47Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions. |
title |
Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions. |
spellingShingle |
Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions. Abel, Lúcia Cristina Jamli Chagas disease Trypanosoma cruzi |
title_short |
Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions. |
title_full |
Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions. |
title_fullStr |
Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions. |
title_full_unstemmed |
Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions. |
title_sort |
Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions. |
author |
Abel, Lúcia Cristina Jamli |
author_facet |
Abel, Lúcia Cristina Jamli Ferreira, Ludmila Rodrigues Pinto Navarro, Isabela Cunha Baron, Monique Andrade Kalil, Jorge Gazzinelli, Ricardo Tostes Rizzo, Luiz Vicente Cunha Neto, Edecio |
author_role |
author |
author2 |
Ferreira, Ludmila Rodrigues Pinto Navarro, Isabela Cunha Baron, Monique Andrade Kalil, Jorge Gazzinelli, Ricardo Tostes Rizzo, Luiz Vicente Cunha Neto, Edecio |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Abel, Lúcia Cristina Jamli Ferreira, Ludmila Rodrigues Pinto Navarro, Isabela Cunha Baron, Monique Andrade Kalil, Jorge Gazzinelli, Ricardo Tostes Rizzo, Luiz Vicente Cunha Neto, Edecio |
dc.subject.en.pt_BR.fl_str_mv |
Chagas disease Trypanosoma cruzi |
topic |
Chagas disease Trypanosoma cruzi |
description |
Universidade de São Paulo. Escola de Medicina. Instituto do Coração. Laboratory of Immunology. São Paulo, SP, Brazil |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2015-03-02T18:05:44Z |
dc.date.available.fl_str_mv |
2015-03-02T18:05:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ABEL, Lúcia Cristina Jamli et al. Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions. Mediators of Inflammation, V. 2014, Article ID 345659, 7 p., 2014 |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/9584 |
dc.identifier.issn.none.fl_str_mv |
0962-9351 |
dc.identifier.doi.none.fl_str_mv |
10.1155/2014/345659 |
identifier_str_mv |
ABEL, Lúcia Cristina Jamli et al. Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions. Mediators of Inflammation, V. 2014, Article ID 345659, 7 p., 2014 0962-9351 10.1155/2014/345659 |
url |
https://www.arca.fiocruz.br/handle/icict/9584 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
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