Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions.

Abel, Lúcia Cristina Jamli; Ferreira, Ludmila Rodrigues Pinto; Navarro, Isabela Cunha; Baron, Monique Andrade; Kalil, Jorge; Gazzinelli, Ricardo Tostes; Rizzo, Luiz Vicente; Cunha Neto, Edecio

Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions.

Detalhes bibliográficos
Autor(a) principal:	Abel, Lúcia Cristina Jamli
Data de Publicação:	2014
Outros Autores:	Ferreira, Ludmila Rodrigues Pinto, Navarro, Isabela Cunha, Baron, Monique Andrade, Kalil, Jorge, Gazzinelli, Ricardo Tostes, Rizzo, Luiz Vicente, Cunha Neto, Edecio
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/9584
Resumo:	Universidade de São Paulo. Escola de Medicina. Instituto do Coração. Laboratory of Immunology. São Paulo, SP, Brazil

Metadados do item

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spelling	Abel, Lúcia Cristina JamliFerreira, Ludmila Rodrigues PintoNavarro, Isabela CunhaBaron, Monique AndradeKalil, JorgeGazzinelli, Ricardo TostesRizzo, Luiz VicenteCunha Neto, Edecio2015-03-02T18:05:44Z2015-03-02T18:05:44Z2014ABEL, Lúcia Cristina Jamli et al. Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions. Mediators of Inflammation, V. 2014, Article ID 345659, 7 p., 20140962-9351https://www.arca.fiocruz.br/handle/icict/958410.1155/2014/345659engHindawi Publishing CorporationInduction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Escola de Medicina. Instituto do Coração. Laboratory of Immunology. São Paulo, SP, BrazilUniversidade de São Paulo. Escola de Medicina. Instituto do Coração. Laboratory of Immunology. São Paulo, SP, Brazil/Universidade de São Paulo. Escola de Medicina. Clinca de Imunologia e Alergia. Sao Paulo, SP, Brazil/Institutos Nacionais de Ciência e Tecnologia. Instituto de Investigação em Imunologia. Sao Paulo, SP, BrazilUniversidade de São Paulo. Escola de Medicina. Instituto do Coração. Laboratory of Immunology. São Paulo, SP, Brazil/Universidade de São Paulo. Escola de Medicina. Clinca de Imunologia e Alergia. Sao Paulo, SP, Brazil/Institutos Nacionais de Ciência e Tecnologia. Instituto de Investigação em Imunologia. Sao Paulo, SP, BrazilUniversidade de São Paulo. Escola de Medicina. Instituto do Coração. Laboratory of Immunology. São Paulo, SP, Brazil/Universidade de São Paulo. Escola de Medicina. Clinca de Imunologia e Alergia. Sao Paulo, SP, Brazil/Institutos Nacionais de Ciência e Tecnologia. Instituto de Investigação em Imunologia. Sao Paulo, SP, BrazilUniversidade de São Paulo. Escola de Medicina. Instituto do Coração. Laboratory of Immunology. São Paulo, SP, Brazil/Universidade de São Paulo. Escola de Medicina. Clinca de Imunologia e Alergia. Sao Paulo, SP, Brazil/Institutos Nacionais de Ciência e Tecnologia. Instituto de Investigação em Imunologia. Sao Paulo, SP, BrazilFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas.Departamento de Bioquimica e Imunologia. Laboratorio de Imunopatologia. Belo Horizonte, MG, Brazil/University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USAHospital Israelita Albert Einstein. Sao Paulo, SP, BrazilUniversidade de São Paulo. Escola de Medicina. Instituto do Coração. Laboratory of Immunology. São Paulo, SP, Brazil/Universidade de São Paulo. Escola de Medicina. Clinca de Imunologia e Alergia. Sao Paulo, SP, Brazil/Institutos Nacionais de Ciência e Tecnologia. Instituto de Investigação em Imunologia. Sao Paulo, SP, BrazilChagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is characterized by immunopathology driven by IFN-γ secreting Th1-like T cells. T. cruzi has a thick coat of mucin-like glycoproteins covering its surface, which plays an important role in parasite invasion and host immunomodulation. It has been extensively described that T. cruzi or its products-like GPI anchors isolated from GPI-anchored mucins from the trypomastigote life cycle stage (tGPI-mucins)-are potent inducers of proinflammatory responses (i.e., cytokines and NO production) by IFN-γ primed murine macrophages. However, little is known about whether T. cruzi or GPI-mucins exert a similar action in human cells. We therefore decided to further investigate the in vitro cytokine production profile from human mononuclear cells from uninfected donors exposed to T. cruzi as well as tGPI-mucins. We observed that both living T. cruzi trypomastigotes and tGPI-mucins are potent inducers of IL-12 by human peripheral blood monocytes and this effect depends on CD40-CD40L interaction and IFN-γ. Our findings suggest that the polarized T1-type cytokine profile seen in T. cruzi infected patients might be a long-term effect of IL-12 production induced by lifelong exposure to T. cruzi tGPI-mucins.Chagas diseaseTrypanosoma cruziinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9584/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINAL2014_132.pdf2014_132.pdfapplication/pdf1484334https://www.arca.fiocruz.br/bitstream/icict/9584/2/2014_132.pdfd096f23e5a1f9d4cd062bfcebc0ee3c2MD52TEXT2014_132.pdf.txt2014_132.pdf.txtExtracted texttext/plain34020https://www.arca.fiocruz.br/bitstream/icict/9584/3/2014_132.pdf.txtef093235de092923e6011051472a1446MD53icict/95842019-06-19 10:07:47.992oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:07:47Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions.
title	Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions.
spellingShingle	Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions. Abel, Lúcia Cristina Jamli Chagas disease Trypanosoma cruzi
title_short	Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions.
title_full	Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions.
title_fullStr	Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions.
title_full_unstemmed	Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions.
title_sort	Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions.
author	Abel, Lúcia Cristina Jamli
author_facet	Abel, Lúcia Cristina Jamli Ferreira, Ludmila Rodrigues Pinto Navarro, Isabela Cunha Baron, Monique Andrade Kalil, Jorge Gazzinelli, Ricardo Tostes Rizzo, Luiz Vicente Cunha Neto, Edecio
author_role	author
author2	Ferreira, Ludmila Rodrigues Pinto Navarro, Isabela Cunha Baron, Monique Andrade Kalil, Jorge Gazzinelli, Ricardo Tostes Rizzo, Luiz Vicente Cunha Neto, Edecio
author2_role	author author author author author author author
dc.contributor.author.fl_str_mv	Abel, Lúcia Cristina Jamli Ferreira, Ludmila Rodrigues Pinto Navarro, Isabela Cunha Baron, Monique Andrade Kalil, Jorge Gazzinelli, Ricardo Tostes Rizzo, Luiz Vicente Cunha Neto, Edecio
dc.subject.en.pt_BR.fl_str_mv	Chagas disease Trypanosoma cruzi
topic	Chagas disease Trypanosoma cruzi
description	Universidade de São Paulo. Escola de Medicina. Instituto do Coração. Laboratory of Immunology. São Paulo, SP, Brazil
publishDate	2014
dc.date.issued.fl_str_mv	2014
dc.date.accessioned.fl_str_mv	2015-03-02T18:05:44Z
dc.date.available.fl_str_mv	2015-03-02T18:05:44Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	ABEL, Lúcia Cristina Jamli et al. Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions. Mediators of Inflammation, V. 2014, Article ID 345659, 7 p., 2014
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/9584
dc.identifier.issn.none.fl_str_mv	0962-9351
dc.identifier.doi.none.fl_str_mv	10.1155/2014/345659
identifier_str_mv	ABEL, Lúcia Cristina Jamli et al. Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions. Mediators of Inflammation, V. 2014, Article ID 345659, 7 p., 2014 0962-9351 10.1155/2014/345659
url	https://www.arca.fiocruz.br/handle/icict/9584
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Hindawi Publishing Corporation
publisher.none.fl_str_mv	Hindawi Publishing Corporation
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/9584/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/9584/2/2014_132.pdf https://www.arca.fiocruz.br/bitstream/icict/9584/3/2014_132.pdf.txt
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Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- and CD40-CD40L Interactions.

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