Expression of annexin A1 in Leishmania-infected skin and its correlation with histopathological features

Detalhes bibliográficos
Autor(a) principal: Silva, Helen Aguiar Lemes da
Data de Publicação: 2015
Outros Autores: Lima, Gabriel Silva de, Boité, Mariana Côrtes, Porrozzi, Renato, Hueb, Marcia, Damazo, Amilcar Sabino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/0037-8682-0183-2015
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12191
Resumo: Universidade Federal de Mato Grosso. Laboratório de Histologia. Pós-Graduação em Ciências da Saúde. Cuiabá, MT, Brasil.
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spelling Silva, Helen Aguiar Lemes daLima, Gabriel Silva deBoité, Mariana CôrtesPorrozzi, RenatoHueb, MarciaDamazo, Amilcar Sabino2015-11-11T15:03:46Z2015-11-11T15:03:46Z2015SILVA, Helen Aguiar Lemes da; et al. Expression of annexin A1 in Leishmania-infected skin and its correlation with histopathological features. Rev. Soc. Bras. Med. Trop., v.48, n.5, p. 560-567, Sept./Oct. 2015.0037-8682https://www.arca.fiocruz.br/handle/icict/1219110.1590/0037-8682-0183-20151678-9849engSociedade Brasileira de Medicina TropicalExpression of annexin A1 in Leishmania-infected skin and its correlation with histopathological featuresinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Mato Grosso. Laboratório de Histologia. Pós-Graduação em Ciências da Saúde. Cuiabá, MT, Brasil.Universidade Federal de Mato Grosso. Faculdade de Medicina. Laboratório de Histologia. Cuiabá, MT, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Leishmaniose. Rio de Janeiro, RJ, Brasil.Universidade Federal de Mato Grosso. Faculdade de Medicina. Hospital Universitário Julio Müller. Cuiabá, MT, Brasil.Universidade Federal de Mato Grosso. Laboratório de Histologia. Pós-Graduação em Ciências da Saúde. Cuiabá, MT, Brasil / Universidade Federal de Mato Grosso. Faculdade de Medicina. Laboratório de Histologia. Cuiabá, MT, Brasil..Introduction: The aim of this study was quantify annexin A1 expression in macrophages and cluster of differentiation 4 (CD4)+ and cluster of differentiation 8 (CD8)+ T cells from the skin of patients with cutaneous leishmaniasis (n=55) and correlate with histopathological aspects. Methods: Infecting species were identifi ed by polymerase chain reaction-restriction fragment length polymorphism, and expression of annexin A1 was analyzed by immunofl uorescence. Results: All patients (n = 55) were infected with Leishmania braziliensis. Annexin A1 was expressed more abundantly in CD163+ macrophages in infected skin (p < 0.0001) than in uninfected skin. In addition, macrophages in necrotic exudative reaction lesions expressed annexin A1 at higher levels than those observed in granulomatous (p < 0.01) and cellular lesions p < 0.05). This difference might be due to the need to clear both parasites and necrotic tissue from necrotic lesions. CD4+ cells in cellular lesions expressed annexin A1 more abundantly than did those in necrotic (p < 0.05) and granulomatous lesions (p < 0.01). Expression in CD8+ T cells followed the same trend. These differences might be due to the pervasiveness of lymphohistiocytic and plasmacytic infi ltrate in cellular lesions. Conclusions: Annexin A1 is differentially expressed in CD163+ macrophages and T cells depending on the histopathological features of Leishmania-infected skin, which might affect cell activation.Cutaneous leishmaniasisAnnexin A1LymphocytesMacrophagesLeishmaniose CutâneaLinfócitosMacrófagosAnexina A1info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12191/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALrenato_porrozi_etal_IOC__2015.pdfrenato_porrozi_etal_IOC__2015.pdfapplication/pdf2863671https://www.arca.fiocruz.br/bitstream/icict/12191/2/renato_porrozi_etal_IOC__2015.pdf6298a8bee25b596dc0917e15b0d7e47cMD52TEXTrenato_porrozi_etal_IOC__2015.pdf.txtrenato_porrozi_etal_IOC__2015.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Expression of annexin A1 in Leishmania-infected skin and its correlation with histopathological features
title Expression of annexin A1 in Leishmania-infected skin and its correlation with histopathological features
spellingShingle Expression of annexin A1 in Leishmania-infected skin and its correlation with histopathological features
Silva, Helen Aguiar Lemes da
Cutaneous leishmaniasis
Annexin A1
Lymphocytes
Macrophages
Leishmaniose Cutânea
Linfócitos
Macrófagos
Anexina A1
title_short Expression of annexin A1 in Leishmania-infected skin and its correlation with histopathological features
title_full Expression of annexin A1 in Leishmania-infected skin and its correlation with histopathological features
title_fullStr Expression of annexin A1 in Leishmania-infected skin and its correlation with histopathological features
title_full_unstemmed Expression of annexin A1 in Leishmania-infected skin and its correlation with histopathological features
title_sort Expression of annexin A1 in Leishmania-infected skin and its correlation with histopathological features
author Silva, Helen Aguiar Lemes da
author_facet Silva, Helen Aguiar Lemes da
Lima, Gabriel Silva de
Boité, Mariana Côrtes
Porrozzi, Renato
Hueb, Marcia
Damazo, Amilcar Sabino
author_role author
author2 Lima, Gabriel Silva de
Boité, Mariana Côrtes
Porrozzi, Renato
Hueb, Marcia
Damazo, Amilcar Sabino
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Helen Aguiar Lemes da
Lima, Gabriel Silva de
Boité, Mariana Côrtes
Porrozzi, Renato
Hueb, Marcia
Damazo, Amilcar Sabino
dc.subject.en.pt_BR.fl_str_mv Cutaneous leishmaniasis
Annexin A1
Lymphocytes
Macrophages
topic Cutaneous leishmaniasis
Annexin A1
Lymphocytes
Macrophages
Leishmaniose Cutânea
Linfócitos
Macrófagos
Anexina A1
dc.subject.decs.pt_BR.fl_str_mv Leishmaniose Cutânea
Linfócitos
Macrófagos
Anexina A1
description Universidade Federal de Mato Grosso. Laboratório de Histologia. Pós-Graduação em Ciências da Saúde. Cuiabá, MT, Brasil.
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-11-11T15:03:46Z
dc.date.available.fl_str_mv 2015-11-11T15:03:46Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Helen Aguiar Lemes da; et al. Expression of annexin A1 in Leishmania-infected skin and its correlation with histopathological features. Rev. Soc. Bras. Med. Trop., v.48, n.5, p. 560-567, Sept./Oct. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12191
dc.identifier.issn.none.fl_str_mv 0037-8682
dc.identifier.doi.none.fl_str_mv 10.1590/0037-8682-0183-2015
dc.identifier.eissn.none.fl_str_mv 1678-9849
identifier_str_mv SILVA, Helen Aguiar Lemes da; et al. Expression of annexin A1 in Leishmania-infected skin and its correlation with histopathological features. Rev. Soc. Bras. Med. Trop., v.48, n.5, p. 560-567, Sept./Oct. 2015.
0037-8682
10.1590/0037-8682-0183-2015
1678-9849
url https://www.arca.fiocruz.br/handle/icict/12191
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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