Circulation of Vaccine-derived Rotavirus G1P[8] in a Vulnerable Child Cohort in Rio de Janeiro

Detalhes bibliográficos
Autor(a) principal: Cunha, Denise Cotrim da
Data de Publicação: 2023
Outros Autores: Fuller, Trevon, Cantelli, Carina Pacheco, Moraes, Marcia Terezinha Baroni de, Leite, José Paulo Gagliardi, Carvalho-Costa, Filipe Anibal, Brasil, Patricia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58787
Resumo: This work was supported by the Carlos Chagas Foundation for the Advancement of Science of the State of Rio de Janeiro (FAPERJ) E-26/200.935/2022, E-26/211.565/2019, E-26/210.146/2020-COVID to PB and the Brazilian National Council for Scientific and Technological Development (CNPq) 311562/2021-3 to P.B.
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spelling Cunha, Denise Cotrim daFuller, TrevonCantelli, Carina PachecoMoraes, Marcia Terezinha Baroni deLeite, José Paulo GagliardiCarvalho-Costa, Filipe AnibalBrasil, Patricia2023-05-28T02:33:11Z2023-05-28T02:33:11Z2023CUNHA, Denise Cotrim da et al. Circulation of Vaccine-derived Rotavirus G1P[8] in a Vulnerable Child Cohort in Rio de Janeiro. The Pediatric Infectious Disease Journal, v. 42, n. 3, p. 247-251, Mar. 2023.0891-3668https://www.arca.fiocruz.br/handle/icict/5878710.1097/INF.00000000000037841532-0987This work was supported by the Carlos Chagas Foundation for the Advancement of Science of the State of Rio de Janeiro (FAPERJ) E-26/200.935/2022, E-26/211.565/2019, E-26/210.146/2020-COVID to PB and the Brazilian National Council for Scientific and Technological Development (CNPq) 311562/2021-3 to P.B.Oswaldo Cruz Foundation. Sergio Arouca National School of Public Health. Rio de Janeiro, RJ, Brazil.University of California. Institute of the Environment and Sustainability. Los Angeles, California, USA / Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Acute Febrile Illnesses Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Comparative and Environmental Virology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Comparative and Environmental Virology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Comparative and Environmental Virology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Epidemiology and Molecular Systematics. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Acute Febrile Illnesses Laboratory. Rio de Janeiro, RJ, Brazil.Background: The expansion of rotavirus (RV) immunization in several countries reduced the burden of acute diarrheal disease (ADD) and diarrhea-associated mortality. Although community transmission of live attenuated monovalent rotavirus vaccine (G1P[8] RV1) virus has been demonstrated in children and household contacts, fecal shedding of these strains in neonates and infants under six weeks of age has never been demonstrated. The objective of the study was to assess ADD and rotavirus vaccine strain shedding before and after immunization through 24 months of age. Methods: This was a prospective cohort study in a low-resource community in which stool samples were collected from neonates from 15 to 45 days of age every 2 weeks, after both doses of G1P[8] RV1, and in subsequent ADD episodes until 2 years of age. RV was detected and genotyped in stool samples by RT-PCR. Results: We enrolled 242 participants who were followed for an average of 23 months. The specific prevalence of G1P[8] RV1 virus was 3.3% in neonates and infants less than six weeks of age, 50% after the first dose, and 25.6% after the second dose. Among the 70 participants with ADD, G1P[8] RV1 virus was identified in only one participant (1.4% prevalence). Conclusions: In vaccinated children, there were no breakthrough infections with G1P[8] RV1 and ADD was rare supporting high vaccine effectiveness. We observed G1P[8] RV1 virus shedding among neonates and infants before the first vaccine dose, providing evidence of transmission of the vaccine strain from immunized children to those who are not yet vaccinated.engWilliams & WilkinsCirculation of Vaccine-derived Rotavirus G1P[8] in a Vulnerable Child Cohort in Rio de Janeiroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleRotavirusCommunity transmissionVaccinationPublic healthCohortChildreninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv Circulation of Vaccine-derived Rotavirus G1P[8] in a Vulnerable Child Cohort in Rio de Janeiro
title Circulation of Vaccine-derived Rotavirus G1P[8] in a Vulnerable Child Cohort in Rio de Janeiro
spellingShingle Circulation of Vaccine-derived Rotavirus G1P[8] in a Vulnerable Child Cohort in Rio de Janeiro
Cunha, Denise Cotrim da
Rotavirus
Community transmission
Vaccination
Public health
Cohort
Children
title_short Circulation of Vaccine-derived Rotavirus G1P[8] in a Vulnerable Child Cohort in Rio de Janeiro
title_full Circulation of Vaccine-derived Rotavirus G1P[8] in a Vulnerable Child Cohort in Rio de Janeiro
title_fullStr Circulation of Vaccine-derived Rotavirus G1P[8] in a Vulnerable Child Cohort in Rio de Janeiro
title_full_unstemmed Circulation of Vaccine-derived Rotavirus G1P[8] in a Vulnerable Child Cohort in Rio de Janeiro
title_sort Circulation of Vaccine-derived Rotavirus G1P[8] in a Vulnerable Child Cohort in Rio de Janeiro
author Cunha, Denise Cotrim da
author_facet Cunha, Denise Cotrim da
Fuller, Trevon
Cantelli, Carina Pacheco
Moraes, Marcia Terezinha Baroni de
Leite, José Paulo Gagliardi
Carvalho-Costa, Filipe Anibal
Brasil, Patricia
author_role author
author2 Fuller, Trevon
Cantelli, Carina Pacheco
Moraes, Marcia Terezinha Baroni de
Leite, José Paulo Gagliardi
Carvalho-Costa, Filipe Anibal
Brasil, Patricia
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cunha, Denise Cotrim da
Fuller, Trevon
Cantelli, Carina Pacheco
Moraes, Marcia Terezinha Baroni de
Leite, José Paulo Gagliardi
Carvalho-Costa, Filipe Anibal
Brasil, Patricia
dc.subject.en.en_US.fl_str_mv Rotavirus
Community transmission
Vaccination
Public health
Cohort
Children
topic Rotavirus
Community transmission
Vaccination
Public health
Cohort
Children
description This work was supported by the Carlos Chagas Foundation for the Advancement of Science of the State of Rio de Janeiro (FAPERJ) E-26/200.935/2022, E-26/211.565/2019, E-26/210.146/2020-COVID to PB and the Brazilian National Council for Scientific and Technological Development (CNPq) 311562/2021-3 to P.B.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-05-28T02:33:11Z
dc.date.available.fl_str_mv 2023-05-28T02:33:11Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CUNHA, Denise Cotrim da et al. Circulation of Vaccine-derived Rotavirus G1P[8] in a Vulnerable Child Cohort in Rio de Janeiro. The Pediatric Infectious Disease Journal, v. 42, n. 3, p. 247-251, Mar. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58787
dc.identifier.issn.en_US.fl_str_mv 0891-3668
dc.identifier.doi.none.fl_str_mv 10.1097/INF.0000000000003784
dc.identifier.eissn.none.fl_str_mv 1532-0987
identifier_str_mv CUNHA, Denise Cotrim da et al. Circulation of Vaccine-derived Rotavirus G1P[8] in a Vulnerable Child Cohort in Rio de Janeiro. The Pediatric Infectious Disease Journal, v. 42, n. 3, p. 247-251, Mar. 2023.
0891-3668
10.1097/INF.0000000000003784
1532-0987
url https://www.arca.fiocruz.br/handle/icict/58787
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Williams & Wilkins
publisher.none.fl_str_mv Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58787/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/58787/2/ve_Denise_Cunha_etal_IOC_INI_ENSP_2023.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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