A novel integrated molecular and serological analysis method to predict new cases of leprosy amongst household contacts

Detalhes bibliográficos
Autor(a) principal: Gama, Rafael Silva
Data de Publicação: 2019
Outros Autores: Souza, Márcio Luís Moreira de, Sarno, Euzenir Nunes, Moraes, Milton Ozório de, Gonçalves, Aline, Stefani, Mariane M. A., Garcia, Raúl Marcel González, Fraga, Lucia Alves de Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34037
Resumo: Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas e DIP. Genética e Biotecnologia. Juiz de Fora, MG, Brasil / Universidade do Vale do Rio Doce. Núcleo de Pesquisa em Imunologia. Governador Valadares, MG, Brasil.
id CRUZ_adbe56ee0062f4ae212d5e7e00ef0a3c
oai_identifier_str oai:www.arca.fiocruz.br:icict/34037
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Gama, Rafael SilvaSouza, Márcio Luís Moreira deSarno, Euzenir NunesMoraes, Milton Ozório deGonçalves, AlineStefani, Mariane M. A.Garcia, Raúl Marcel GonzálezFraga, Lucia Alves de Oliveira2019-07-12T17:57:14Z2019-07-12T17:57:14Z2019GAMA, Rafael Silva et al. A novel integrated molecular and serological analysis method to predict new cases of leprosy amongst household contacts. PLoS Neglected Tropical Diseases, v. 13, n. 6, p. 1-22, June 2019.1935-2727https://www.arca.fiocruz.br/handle/icict/3403710.1371/journal.pntd.00074001935-2735engPublic Library of ScienceHanseníaseNovo métodoAnálise molecular e sorológicaContatos domiciliaresMolecular and serological analysisLeprosyHousehold contactsNew methodMolecular and serological analysisA novel integrated molecular and serological analysis method to predict new cases of leprosy amongst household contactsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Juiz de Fora. Instituto de Ciências Biológicas e DIP. Genética e Biotecnologia. Juiz de Fora, MG, Brasil / Universidade do Vale do Rio Doce. Núcleo de Pesquisa em Imunologia. Governador Valadares, MG, Brasil.Universidade Federal de Juiz de Fora. Campus GV. Departamento Básico de Saúde. Programa Multicêntrico de Bioquímica e Biologia Molecular. Governador Valadares, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Sáude Pública. Goiânia, GO, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Sáude Pública. Goiânia, GO, Brasil.Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas e DIP/Genética e Biotecnologia. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Campus GV. Departamento Básico de Saúde. Programa Multicêntrico de Bioquímica e Biologia Molecular. Governador Valadares, MG, Brasil.Early detection of Mycobacterium leprae is a key strategy for disrupting the transmission chain of leprosy and preventing the potential onset of physical disabilities. Clinical diagnosis is essential, but some of the presented symptoms may go unnoticed, even by specialists. In areas of greater endemicity, serological and molecular tests have been performed and analyzed separately for the follow-up of household contacts, who are at high risk of developing the disease. The accuracy of these tests is still debated, and it is necessary to make them more reliable, especially for the identification of cases of leprosy between contacts. We proposed an integrated analysis of molecular and serological methods using artificial intelligence by the random forest (RF) algorithm to better diagnose and predict new cases of leprosy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/34037/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMiltonOzorio_Euzenirsarno_etal_IOC_2019.pdfMiltonOzorio_Euzenirsarno_etal_IOC_2019.pdfapplication/pdf1021001https://www.arca.fiocruz.br/bitstream/icict/34037/2/MiltonOzorio_Euzenirsarno_etal_IOC_2019.pdff132135e088269e3a833460dfd22c96eMD52TEXTMiltonOzorio_Euzenirsarno_etal_IOC_2019.pdf.txtMiltonOzorio_Euzenirsarno_etal_IOC_2019.pdf.txtExtracted texttext/plain62585https://www.arca.fiocruz.br/bitstream/icict/34037/3/MiltonOzorio_Euzenirsarno_etal_IOC_2019.pdf.txtdbd54ef2f3fc0d7f2994cd730a2d1e90MD53icict/340372019-07-15 14:49:05.987oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-07-15T17:49:05Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv A novel integrated molecular and serological analysis method to predict new cases of leprosy amongst household contacts
title A novel integrated molecular and serological analysis method to predict new cases of leprosy amongst household contacts
spellingShingle A novel integrated molecular and serological analysis method to predict new cases of leprosy amongst household contacts
Gama, Rafael Silva
Hanseníase
Novo método
Análise molecular e sorológica
Contatos domiciliares
Molecular and serological analysis
Leprosy
Household contacts
New method
Molecular and serological analysis
title_short A novel integrated molecular and serological analysis method to predict new cases of leprosy amongst household contacts
title_full A novel integrated molecular and serological analysis method to predict new cases of leprosy amongst household contacts
title_fullStr A novel integrated molecular and serological analysis method to predict new cases of leprosy amongst household contacts
title_full_unstemmed A novel integrated molecular and serological analysis method to predict new cases of leprosy amongst household contacts
title_sort A novel integrated molecular and serological analysis method to predict new cases of leprosy amongst household contacts
author Gama, Rafael Silva
author_facet Gama, Rafael Silva
Souza, Márcio Luís Moreira de
Sarno, Euzenir Nunes
Moraes, Milton Ozório de
Gonçalves, Aline
Stefani, Mariane M. A.
Garcia, Raúl Marcel González
Fraga, Lucia Alves de Oliveira
author_role author
author2 Souza, Márcio Luís Moreira de
Sarno, Euzenir Nunes
Moraes, Milton Ozório de
Gonçalves, Aline
Stefani, Mariane M. A.
Garcia, Raúl Marcel González
Fraga, Lucia Alves de Oliveira
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gama, Rafael Silva
Souza, Márcio Luís Moreira de
Sarno, Euzenir Nunes
Moraes, Milton Ozório de
Gonçalves, Aline
Stefani, Mariane M. A.
Garcia, Raúl Marcel González
Fraga, Lucia Alves de Oliveira
dc.subject.other.pt_BR.fl_str_mv Hanseníase
Novo método
Análise molecular e sorológica
Contatos domiciliares
topic Hanseníase
Novo método
Análise molecular e sorológica
Contatos domiciliares
Molecular and serological analysis
Leprosy
Household contacts
New method
Molecular and serological analysis
dc.subject.en.pt_BR.fl_str_mv Molecular and serological analysis
Leprosy
Household contacts
New method
Molecular and serological analysis
description Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas e DIP. Genética e Biotecnologia. Juiz de Fora, MG, Brasil / Universidade do Vale do Rio Doce. Núcleo de Pesquisa em Imunologia. Governador Valadares, MG, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-07-12T17:57:14Z
dc.date.available.fl_str_mv 2019-07-12T17:57:14Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GAMA, Rafael Silva et al. A novel integrated molecular and serological analysis method to predict new cases of leprosy amongst household contacts. PLoS Neglected Tropical Diseases, v. 13, n. 6, p. 1-22, June 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34037
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0007400
dc.identifier.eissn.none.fl_str_mv 1935-2735
identifier_str_mv GAMA, Rafael Silva et al. A novel integrated molecular and serological analysis method to predict new cases of leprosy amongst household contacts. PLoS Neglected Tropical Diseases, v. 13, n. 6, p. 1-22, June 2019.
1935-2727
10.1371/journal.pntd.0007400
1935-2735
url https://www.arca.fiocruz.br/handle/icict/34037
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/34037/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/34037/2/MiltonOzorio_Euzenirsarno_etal_IOC_2019.pdf
https://www.arca.fiocruz.br/bitstream/icict/34037/3/MiltonOzorio_Euzenirsarno_etal_IOC_2019.pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
f132135e088269e3a833460dfd22c96e
dbd54ef2f3fc0d7f2994cd730a2d1e90
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813008926395858944

Registros relacionados