Origin and Population Dynamics of a Novel HIV-1 Subtype G Clade Circulating in Cape Verde and Portugal

Detalhes bibliográficos
Autor(a) principal: Araujo, Isabel Inês M. de Pina
Data de Publicação: 2015
Outros Autores: Delatorre, Edson, Guimarães, Monick L., Morgado, Mariza G., Bello, Gonzalo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12362
Resumo: Universidade de Cabo Verde. Departamento de Ciência e Tecnologia. Praia, Santiago, Cabo Verde.
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spelling Araujo, Isabel Inês M. de PinaDelatorre, EdsonGuimarães, Monick L.Morgado, Mariza G.Bello, Gonzalo2015-12-08T15:10:30Z2015-12-08T15:10:30Z2015ARAUJO, Isabel Inês M. de; et al. Origin and Population Dynamics of a Novel HIV-1 Subtype G Clade Circulating in Cape Verde and Portugal. Plos One, v.10, n.5, e0127384, 16p, May 2015.1932-6203https://www.arca.fiocruz.br/handle/icict/1236210.1371/journal.pone.0127384engPlos OneCabo VerdePortugalHIV - 1Dinâmica PopulacionalHIV-1 Subtype GCape VerdePortugalPopulation DynamicsOrigin and Population Dynamics of a Novel HIV-1 Subtype G Clade Circulating in Cape Verde and Portugalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de Cabo Verde. Departamento de Ciência e Tecnologia. Praia, Santiago, Cabo Verde.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.The human immunodeficiency virus type 1 (HIV-1) subtype G is the most prevalent and second most prevalent HIV-1 clade in Cape Verde and Portugal, respectively; but there is no information about the origin and spatiotemporal dispersal pattern of this HIV-1 clade circulating in those countries. To this end, we used Maximum Likelihood and Bayesian coalescent-based methods to analyze a collection of 578 HIV-1 subtype G pol sequences sampled throughout Portugal, Cape Verde and 11 other countries from West and Central Africa over a period of 22 years (1992 to 2013). Our analyses indicate that most subtype G sequences from Cape Verde (80%) and Portugal (95%) branched together in a distinct monophyletic cluster (here called GCV-PT). The GCV-PT clade probably emerged after a single migration of the virus out of Central Africa into Cape Verde between the late 1970s and the middle 1980s, followed by a rapid dissemination to Portugal a couple of years later. Reconstruction of the demographic history of the GCV-PT clade circulating in Cape Verde and Portugal indicates that this viral clade displayed an initial phase of exponential growth during the 1980s and 1990s, followed by a decline in growth rate since the early 2000s. Our data also indicate that during the exponential growth phase the GCV-PT clade recombined with a preexisting subtype B viral strain circulating in Portugal, originating the CRF14_BG clade that was later disseminated to Spain and Cape Verde. Historical and recent human population movements between Angola, Cape Verde and Portugal probably played a key role in the origin and dispersal of the GCV-PT and CRF14_BG clades.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12362/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmariza_morgado_etal_IOC-2015.pdfmariza_morgado_etal_IOC-2015.pdfapplication/pdf4774012https://www.arca.fiocruz.br/bitstream/icict/12362/2/mariza_morgado_etal_IOC-2015.pdf8673546adecb24ea43f485da49e14111MD52TEXTmariza_morgado_etal_IOC-2015.pdf.txtmariza_morgado_etal_IOC-2015.pdf.txtExtracted texttext/plain48443https://www.arca.fiocruz.br/bitstream/icict/12362/3/mariza_morgado_etal_IOC-2015.pdf.txt15acf0635cca1812b96d2a0294512fc1MD53icict/123622023-09-05 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dc.title.pt_BR.fl_str_mv Origin and Population Dynamics of a Novel HIV-1 Subtype G Clade Circulating in Cape Verde and Portugal
title Origin and Population Dynamics of a Novel HIV-1 Subtype G Clade Circulating in Cape Verde and Portugal
spellingShingle Origin and Population Dynamics of a Novel HIV-1 Subtype G Clade Circulating in Cape Verde and Portugal
Araujo, Isabel Inês M. de Pina
Cabo Verde
Portugal
HIV - 1
Dinâmica Populacional
HIV-1 Subtype G
Cape Verde
Portugal
Population Dynamics
title_short Origin and Population Dynamics of a Novel HIV-1 Subtype G Clade Circulating in Cape Verde and Portugal
title_full Origin and Population Dynamics of a Novel HIV-1 Subtype G Clade Circulating in Cape Verde and Portugal
title_fullStr Origin and Population Dynamics of a Novel HIV-1 Subtype G Clade Circulating in Cape Verde and Portugal
title_full_unstemmed Origin and Population Dynamics of a Novel HIV-1 Subtype G Clade Circulating in Cape Verde and Portugal
title_sort Origin and Population Dynamics of a Novel HIV-1 Subtype G Clade Circulating in Cape Verde and Portugal
author Araujo, Isabel Inês M. de Pina
author_facet Araujo, Isabel Inês M. de Pina
Delatorre, Edson
Guimarães, Monick L.
Morgado, Mariza G.
Bello, Gonzalo
author_role author
author2 Delatorre, Edson
Guimarães, Monick L.
Morgado, Mariza G.
Bello, Gonzalo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Araujo, Isabel Inês M. de Pina
Delatorre, Edson
Guimarães, Monick L.
Morgado, Mariza G.
Bello, Gonzalo
dc.subject.other.pt_BR.fl_str_mv Cabo Verde
Portugal
HIV - 1
Dinâmica Populacional
topic Cabo Verde
Portugal
HIV - 1
Dinâmica Populacional
HIV-1 Subtype G
Cape Verde
Portugal
Population Dynamics
dc.subject.en.pt_BR.fl_str_mv HIV-1 Subtype G
Cape Verde
Portugal
Population Dynamics
description Universidade de Cabo Verde. Departamento de Ciência e Tecnologia. Praia, Santiago, Cabo Verde.
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-12-08T15:10:30Z
dc.date.available.fl_str_mv 2015-12-08T15:10:30Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARAUJO, Isabel Inês M. de; et al. Origin and Population Dynamics of a Novel HIV-1 Subtype G Clade Circulating in Cape Verde and Portugal. Plos One, v.10, n.5, e0127384, 16p, May 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12362
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0127384
identifier_str_mv ARAUJO, Isabel Inês M. de; et al. Origin and Population Dynamics of a Novel HIV-1 Subtype G Clade Circulating in Cape Verde and Portugal. Plos One, v.10, n.5, e0127384, 16p, May 2015.
1932-6203
10.1371/journal.pone.0127384
url https://www.arca.fiocruz.br/handle/icict/12362
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Plos One
publisher.none.fl_str_mv Plos One
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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