Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions"

Shikanai-Yasuda, Maria Aparecida; Mediano, Mauro Felippe Felix; Novaes, Christina Terra Gallafrio; Sousa, Andréa Silvestre de; Sartori, Ana Marli Christovam; Santana, Rodrigo Carvalho; Correia, Dalmo; Castro, Cleudson Nery de; Severo, Marilia Maria dos Santos; Hasslocher-Moreno, Alejandro Marcel; Fernandez, Marisa Liliana; Salvador, Fernando; Pinazo, Maria Jesús; Bolella, Valdes Roberto; Furtado, Pedro Carvalho; Corti, Marcelo; Pinto, Ana Yecê Neves; Fica, Alberto; Molina, Israel; Gascon, Joaquim; Viñas, Pedro Albajar; Cortez-Escalante, Juan; Ramos Jr, Alberto Novaes; Almeida, Eros Antonio de

Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions"

Detalhes bibliográficos
Autor(a) principal:	Shikanai-Yasuda, Maria Aparecida
Data de Publicação:	2021
Outros Autores:	Mediano, Mauro Felippe Felix, Novaes, Christina Terra Gallafrio, Sousa, Andréa Silvestre de, Sartori, Ana Marli Christovam, Santana, Rodrigo Carvalho, Correia, Dalmo, Castro, Cleudson Nery de, Severo, Marilia Maria dos Santos, Hasslocher-Moreno, Alejandro Marcel, Fernandez, Marisa Liliana, Salvador, Fernando, Pinazo, Maria Jesús, Bolella, Valdes Roberto, Furtado, Pedro Carvalho, Corti, Marcelo, Pinto, Ana Yecê Neves, Fica, Alberto, Molina, Israel, Gascon, Joaquim, Viñas, Pedro Albajar, Cortez-Escalante, Juan, Ramos Jr, Alberto Novaes, Almeida, Eros Antonio de
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/50275
Resumo:	University of São Paulo. Faculdade de Medicina. Departament of Infectious and Parasitic. São Paulo, SP, Brazil / University of São Paulo. Faculdade de Medicina. Hospital das Clínicas. Laboratory of Immunology. São Paulo, SP, Brazil / WHO Technical Group IVb on prevention, control and management of non congenital infections of the Global Network for Chagas Disease Elimination. Geneva, Switzerland.

Metadados do item

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network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Shikanai-Yasuda, Maria AparecidaMediano, Mauro Felippe FelixNovaes, Christina Terra GallafrioSousa, Andréa Silvestre deSartori, Ana Marli ChristovamSantana, Rodrigo CarvalhoCorreia, DalmoCastro, Cleudson Nery deSevero, Marilia Maria dos SantosHasslocher-Moreno, Alejandro MarcelFernandez, Marisa LilianaSalvador, FernandoPinazo, Maria JesúsBolella, Valdes RobertoFurtado, Pedro CarvalhoCorti, MarceloPinto, Ana Yecê NevesFica, AlbertoMolina, IsraelGascon, JoaquimViñas, Pedro AlbajarCortez-Escalante, JuanRamos Jr, Alberto NovaesAlmeida, Eros Antonio de2021-12-09T22:38:42Z2021-12-09T22:38:42Z2021SHIKANAI-YASUDA, Maria Aparecida et al. Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions". PLoS neglected tropical diseases, v. 15, n. 9, p. 1-18, 20211935-2735https://www.arca.fiocruz.br/handle/icict/5027510.1371/journal.pntd.0009809engPublic Library of ScienceClinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions"info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of São Paulo. Faculdade de Medicina. Departament of Infectious and Parasitic. São Paulo, SP, Brazil / University of São Paulo. Faculdade de Medicina. Hospital das Clínicas. Laboratory of Immunology. São Paulo, SP, Brazil / WHO Technical Group IVb on prevention, control and management of non congenital infections of the Global Network for Chagas Disease Elimination. Geneva, Switzerland.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.University of São Paulo. Faculdade de Medicina. Hospital das Clínicas. Division of Infectious Diseases. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.University of São Paulo. Faculdade de Medicina. Hospital das Clínicas. Division of Infectious Diseases. São Paulo, SP, Brazil.Ribeirão Preto Medical School University of São Paulo. Department of Internal Medicine. Division of Infectious Diseases. Ribeirão Preto, SP, Brazil.Federal University of Triângulo Mineiro. Department of Internal Medicine. Discipline of Infectious and Parasitic Diseases. Uberaba, MG, Brazil.University of Brasilia. School of Medicine. Centre for Tropical Medicine. Brasília, DF, Brazil.Federal University of Health Sciences of Porto Alegre. Porto Alegre, RS, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Hospital de Infecciosas. Buenos Aires, Argentina / Health Ministry. National Institute of Parasitology. Departament of Clinics, Pathology and Treatment. Buenos Aires, Argentina.Universitat Autònoma de Barcelona. Vall d'Hebron University Hospital. Department of Infectious Diseases. Barcelona, Spain.ISGlobal. Universitat de Barcelona. Hospital Clínic. Barcelona, Spain.Ribeirão Preto Medical School University of São Paulo. Department of Internal Medicine. Division of Infectious Diseases. Ribeirão Preto, SP, Brazil.Federal University of Triângulo Mineiro. Department of Internal Medicine. Discipline of Infectious and Parasitic Diseases. Uberaba, MG, Brazil.Hospital de Infecciosas. Buenos Aires, Argentina / Universidad Buenos Aires. Facultad de Medicina. Asignatura Enfermedades Infecciosas. Departamento de Medicina. Buenos Aires, Argentina.Health Ministry. Health Surveillance Secretary. Evandro Chagas Institute. Belém, PA, Brazil.Universidad Austral de Chile. Facultad de Medicina. Valdivia, Chile.Universitat Autònoma de Barcelona. Vall d'Hebron University Hospital. Department of Infectious Diseases. Barcelona, Spain.ISGlobal. Universitat de Barcelona. Hospital Clínic. Barcelona, Spain.World Health Organization. WHO Technical Group IVb on prevention, control and management of non congenital infections of the Global Network for Chagas Disease Elimination. Geneva, Switzerland / World Health Organization. Department of Control of Neglected Tropical Diseases. Geneva, Switzerland.World Health Organization. Pan American Health Organization. Brasília, DF, Brazil.Federal University of Ceará. School of Medicine. Department of Community Health. Fortaleza, CE, Brazil.State University of Campinas. Faculty of Medical Sciences. Department of Internal Medicine. Campinas, SP, Brazil.Objective: Chagas disease (CD) globalization facilitated the co-infection with Human Immunodeficiency Virus (HIV) in endemic and non-endemic areas. Considering the underestimation of Trypanosoma cruzi (T. cruzi)-HIV co-infection and the risk of life-threatening Chagas Disease Reactivation (CDR), this study aimed to analyze the major co-infection clinical characteristics and its mortality rates. Methods: This is a cross-sectional retrospective multicenter study of patients with CD confirmed by two serological or one parasitological tests, and HIV infection confirmed by immunoblot. CDR was diagnosed by direct microscopy with detection of trypomastigote forms in the blood or other biological fluids and/or amastigote forms in inflammatory lesions. Results: Out of 241 patients with co-infection, 86.7% were from Brazil, 47.5% had <200 CD4+ T cells/μL and median viral load was 17,000 copies/μL. Sixty CDR cases were observed. Death was more frequent in patients with reactivation and was mainly caused by CDR. Other causes of death unrelated to CDR were the manifestation of opportunistic infections in those with Acquired Immunodeficiency Syndrome. The time between the co-infection diagnosis to death was shorter in patients with CDR. Lower CD4+ cells count at co-infection diagnosis was independently associated with reactivation. Similarly, lower CD4+ cells numbers at co-infection diagnosis and male sex were associated with higher lethality in CDR. Additionally, CD4+ cells were lower in meningoencephalitis than in myocarditis and milder forms. Conclusion: This study showed major features on T. cruzi-HIV co-infection and highlighted the prognostic role of CD4+ cells for reactivation and mortality. Since lethality was high in meningoencephalitis and all untreated patients died shortly after the diagnosis, early diagnosis, immediate antiparasitic treatment, patient follow-up and epidemiological surveillance are essentials in T. cruzi/HIV co-infection and CDR managements.Co-infectionsHIV diagnosis and managementTrypanosoma cruziMeningoencephalitisAntiparasitic therapyParasitic diseasesHIV infectionsChagas diseaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/50275/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALClinical_Mauro_Mediano_etal_INI_2021.pdfClinical_Mauro_Mediano_etal_INI_2021.pdfapplication/pdf728525https://www.arca.fiocruz.br/bitstream/icict/50275/2/Clinical_Mauro_Mediano_etal_INI_2021.pdf26d5740a49480148f673616b91c71dd6MD52icict/502752021-12-09 19:38:42.993oai:www.arca.fiocruz.br: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ório 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dc.title.pt_BR.fl_str_mv	Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions"
title	Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions"
spellingShingle	Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions" Shikanai-Yasuda, Maria Aparecida Co-infections HIV diagnosis and management Trypanosoma cruzi Meningoencephalitis Antiparasitic therapy Parasitic diseases HIV infections Chagas disease
title_short	Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions"
title_full	Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions"
title_fullStr	Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions"
title_full_unstemmed	Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions"
title_sort	Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions"
author	Shikanai-Yasuda, Maria Aparecida
author_facet	Shikanai-Yasuda, Maria Aparecida Mediano, Mauro Felippe Felix Novaes, Christina Terra Gallafrio Sousa, Andréa Silvestre de Sartori, Ana Marli Christovam Santana, Rodrigo Carvalho Correia, Dalmo Castro, Cleudson Nery de Severo, Marilia Maria dos Santos Hasslocher-Moreno, Alejandro Marcel Fernandez, Marisa Liliana Salvador, Fernando Pinazo, Maria Jesús Bolella, Valdes Roberto Furtado, Pedro Carvalho Corti, Marcelo Pinto, Ana Yecê Neves Fica, Alberto Molina, Israel Gascon, Joaquim Viñas, Pedro Albajar Cortez-Escalante, Juan Ramos Jr, Alberto Novaes Almeida, Eros Antonio de
author_role	author
author2	Mediano, Mauro Felippe Felix Novaes, Christina Terra Gallafrio Sousa, Andréa Silvestre de Sartori, Ana Marli Christovam Santana, Rodrigo Carvalho Correia, Dalmo Castro, Cleudson Nery de Severo, Marilia Maria dos Santos Hasslocher-Moreno, Alejandro Marcel Fernandez, Marisa Liliana Salvador, Fernando Pinazo, Maria Jesús Bolella, Valdes Roberto Furtado, Pedro Carvalho Corti, Marcelo Pinto, Ana Yecê Neves Fica, Alberto Molina, Israel Gascon, Joaquim Viñas, Pedro Albajar Cortez-Escalante, Juan Ramos Jr, Alberto Novaes Almeida, Eros Antonio de
author2_role	author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Shikanai-Yasuda, Maria Aparecida Mediano, Mauro Felippe Felix Novaes, Christina Terra Gallafrio Sousa, Andréa Silvestre de Sartori, Ana Marli Christovam Santana, Rodrigo Carvalho Correia, Dalmo Castro, Cleudson Nery de Severo, Marilia Maria dos Santos Hasslocher-Moreno, Alejandro Marcel Fernandez, Marisa Liliana Salvador, Fernando Pinazo, Maria Jesús Bolella, Valdes Roberto Furtado, Pedro Carvalho Corti, Marcelo Pinto, Ana Yecê Neves Fica, Alberto Molina, Israel Gascon, Joaquim Viñas, Pedro Albajar Cortez-Escalante, Juan Ramos Jr, Alberto Novaes Almeida, Eros Antonio de
dc.subject.en.pt_BR.fl_str_mv	Co-infections HIV diagnosis and management Trypanosoma cruzi Meningoencephalitis Antiparasitic therapy Parasitic diseases HIV infections Chagas disease
topic	Co-infections HIV diagnosis and management Trypanosoma cruzi Meningoencephalitis Antiparasitic therapy Parasitic diseases HIV infections Chagas disease
description	University of São Paulo. Faculdade de Medicina. Departament of Infectious and Parasitic. São Paulo, SP, Brazil / University of São Paulo. Faculdade de Medicina. Hospital das Clínicas. Laboratory of Immunology. São Paulo, SP, Brazil / WHO Technical Group IVb on prevention, control and management of non congenital infections of the Global Network for Chagas Disease Elimination. Geneva, Switzerland.
publishDate	2021
dc.date.accessioned.fl_str_mv	2021-12-09T22:38:42Z
dc.date.available.fl_str_mv	2021-12-09T22:38:42Z
dc.date.issued.fl_str_mv	2021
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	SHIKANAI-YASUDA, Maria Aparecida et al. Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions". PLoS neglected tropical diseases, v. 15, n. 9, p. 1-18, 2021
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/50275
dc.identifier.issn.pt_BR.fl_str_mv	1935-2735
dc.identifier.doi.none.fl_str_mv	10.1371/journal.pntd.0009809
identifier_str_mv	SHIKANAI-YASUDA, Maria Aparecida et al. Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions". PLoS neglected tropical diseases, v. 15, n. 9, p. 1-18, 2021 1935-2735 10.1371/journal.pntd.0009809
url	https://www.arca.fiocruz.br/handle/icict/50275
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Public Library of Science
publisher.none.fl_str_mv	Public Library of Science
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/50275/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/50275/2/Clinical_Mauro_Mediano_etal_INI_2021.pdf
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bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions"

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