Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men

Bibliographic Details
Main Author: Gazzinelli, Ricardo Tostes
Publication Date: 2014
Other Authors: Mendonca Neto, Rondon, Lilue, Jingtao, Howard, Jonathan, Sher, Alan
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/11397
Summary: Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, Brazil/University of Massachusetts Medical School. Division of Infectious Diseases and Immunology. Worcester, MA, USA
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spelling Gazzinelli, Ricardo TostesMendonca Neto, RondonLilue, JingtaoHoward, JonathanSher, Alan2015-07-21T17:59:20Z2015-07-21T17:59:20Z2014GAZZINELLI, Ricardo Tostes et al. Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men. Cell Host Microbe, vol. 15, n. 2, p. 132-8. 20141931-3128https://www.arca.fiocruz.br/handle/icict/1139710.1016/j.chom.2014.01.004engCell PressInnate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Meninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, Brazil/University of Massachusetts Medical School. Division of Infectious Diseases and Immunology. Worcester, MA, USAUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, BrazilUniversity of Cologne. Institute for Genetics. Cologne, GermanyUniversity of Cologne. Institute for Genetics. Cologne, Germany/Instituto Gulbenkian de Ciencia. Oeiras, PortugalNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USARecent studies have revealed remarkable species specificity of the Toll-like receptors (TLRs) TLR11 and TLR12 and the immunity-related GTPase (IRG) proteins that are essential elements for detection and immune control of Toxoplasma gondii in mice, but not in humans. The biological and evolutionary implications of these findings for the T. gondii host-pathogen relationship and for human disease are discussed.Toxoplasma gondiiinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11397/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALInnate Resistance against Toxoplasma gondii- An Evolutionary Tale of Mice, Cats, and Men.pdfInnate Resistance against Toxoplasma gondii- An Evolutionary Tale of Mice, Cats, and Men.pdfapplication/pdf1199408https://www.arca.fiocruz.br/bitstream/icict/11397/2/Innate%20Resistance%20against%20Toxoplasma%20gondii-%20An%20Evolutionary%20Tale%20of%20Mice%2c%20Cats%2c%20and%20Men.pdf4d1bed7034f47c642f7fd88134b3c9f6MD52TEXTInnate Resistance against Toxoplasma gondii- An Evolutionary Tale of Mice, Cats, and Men.pdf.txtInnate Resistance against Toxoplasma gondii- An Evolutionary Tale of Mice, Cats, and Men.pdf.txtExtracted texttext/plain36782https://www.arca.fiocruz.br/bitstream/icict/11397/3/Innate%20Resistance%20against%20Toxoplasma%20gondii-%20An%20Evolutionary%20Tale%20of%20Mice%2c%20Cats%2c%20and%20Men.pdf.txt5e588223641356a672761b00bc760e6bMD53icict/113972019-06-19 10:06:36.135oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:06:36Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men
title Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men
spellingShingle Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men
Gazzinelli, Ricardo Tostes
Toxoplasma gondii
title_short Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men
title_full Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men
title_fullStr Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men
title_full_unstemmed Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men
title_sort Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men
author Gazzinelli, Ricardo Tostes
author_facet Gazzinelli, Ricardo Tostes
Mendonca Neto, Rondon
Lilue, Jingtao
Howard, Jonathan
Sher, Alan
author_role author
author2 Mendonca Neto, Rondon
Lilue, Jingtao
Howard, Jonathan
Sher, Alan
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Gazzinelli, Ricardo Tostes
Mendonca Neto, Rondon
Lilue, Jingtao
Howard, Jonathan
Sher, Alan
dc.subject.en.pt_BR.fl_str_mv Toxoplasma gondii
topic Toxoplasma gondii
description Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, Brazil/University of Massachusetts Medical School. Division of Infectious Diseases and Immunology. Worcester, MA, USA
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-07-21T17:59:20Z
dc.date.available.fl_str_mv 2015-07-21T17:59:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GAZZINELLI, Ricardo Tostes et al. Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men. Cell Host Microbe, vol. 15, n. 2, p. 132-8. 2014
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11397
dc.identifier.issn.none.fl_str_mv 1931-3128
dc.identifier.doi.none.fl_str_mv 10.1016/j.chom.2014.01.004
identifier_str_mv GAZZINELLI, Ricardo Tostes et al. Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men. Cell Host Microbe, vol. 15, n. 2, p. 132-8. 2014
1931-3128
10.1016/j.chom.2014.01.004
url https://www.arca.fiocruz.br/handle/icict/11397
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/11397/1/license.txt
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