TGF-β polymorphisms are a risk factor for Chagas disease
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31410 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. |
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Ferreira, Roberto RodriguesMadeira, Fabiana da SilvaAlves, Gabriel FariasChambela, Mayara da CostaCurvo, Eduardo de Oliveira VazMoreira, Aline dos SantosSá, Renata Almeida deMendonça-Lima, LeilaCabello, Pedro HernanBailly, SabineFeige, Jean-JacquesAraujo-Jorge, Tania CremoniniSaraiva, Roberto MagalhãesWaghabi, Mariana Caldas2019-02-05T11:06:07Z2019-02-05T11:06:07Z2018FERREIRA, Roberto Rodrigues et al. TGF-β polymorphisms are a risk factor for Chagas disease. Disease Markers, p. 1-10, 18 Feb. 2018.0278-0240https://www.arca.fiocruz.br/handle/icict/3141010.1155/2018/4579198engHindawiTGF-β polymorphisms are a risk factor for Chagas diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil / Universidade do Grande Rio. Laboratório de Genética. Duque de Caxias, RJ, Brasil.INSERM. Grenoble, France / University Grenoble-Alpes. Grenoble, France / CEA, BIG-Biologie du Cancer et de l’Infection. Grenoble, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Transforming growth factor β1 (TGF-β1) is an important mediator in Chagas disease. Furthermore, patients with higher TGF-β1 serum levels show a worse clinical outcome. Gene polymorphism may account for differences in cytokine production during infectious diseases. We tested whether TGFB1 polymorphisms could be associated with Chagas disease susceptibility and severity in a Brazilian population. We investigated five single-nucleotide polymorphisms (-800 G>A, -509 C>T, +10 T>C, +25 G>C, and +263 C>T). 152 patients with Chagas disease (53 with the indeterminate form and 99 with the cardiac form) and 48 noninfected subjects were included. Genotypes CT and TT at position -509 of the TGFB1 gene were more frequent in Chagas disease patients than in noninfected subjects. Genotypes TC and CC at codon +10 of the TGFB1 gene were also more frequent in Chagas disease patients than in noninfected subjects. We found no significant differences in the distribution of the studied TGFB1 polymorphisms between patients with the indeterminate or cardiac form of Chagas disease. Therefore, -509 C>T and +10 T>C TGFB1 polymorphisms are associated with Chagas disease susceptibility in a Brazilian population.Chagas diseaseTGF-β Polymorphismsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Ferreira_Roberto_etal_INI_2018.pdfve_Ferreira_Roberto_etal_INI_2018.pdfapplication/pdf1155807https://www.arca.fiocruz.br/bitstream/icict/31410/2/ve_Ferreira_Roberto_etal_INI_2018.pdf49a7a4dfd6230f5bf50923c8cd975dddMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31410/3/license.txt5a560609d32a3863062d77ff32785d58MD53TEXTve_Ferreira_Roberto_etal_INI_2018.pdf.txtve_Ferreira_Roberto_etal_INI_2018.pdf.txtExtracted texttext/plain42764https://www.arca.fiocruz.br/bitstream/icict/31410/4/ve_Ferreira_Roberto_etal_INI_2018.pdf.txtf573ae01069f9ace4b4895506a77286eMD54icict/314102019-02-17 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dc.title.pt_BR.fl_str_mv |
TGF-β polymorphisms are a risk factor for Chagas disease |
title |
TGF-β polymorphisms are a risk factor for Chagas disease |
spellingShingle |
TGF-β polymorphisms are a risk factor for Chagas disease Ferreira, Roberto Rodrigues Chagas disease TGF-β Polymorphisms |
title_short |
TGF-β polymorphisms are a risk factor for Chagas disease |
title_full |
TGF-β polymorphisms are a risk factor for Chagas disease |
title_fullStr |
TGF-β polymorphisms are a risk factor for Chagas disease |
title_full_unstemmed |
TGF-β polymorphisms are a risk factor for Chagas disease |
title_sort |
TGF-β polymorphisms are a risk factor for Chagas disease |
author |
Ferreira, Roberto Rodrigues |
author_facet |
Ferreira, Roberto Rodrigues Madeira, Fabiana da Silva Alves, Gabriel Farias Chambela, Mayara da Costa Curvo, Eduardo de Oliveira Vaz Moreira, Aline dos Santos Sá, Renata Almeida de Mendonça-Lima, Leila Cabello, Pedro Hernan Bailly, Sabine Feige, Jean-Jacques Araujo-Jorge, Tania Cremonini Saraiva, Roberto Magalhães Waghabi, Mariana Caldas |
author_role |
author |
author2 |
Madeira, Fabiana da Silva Alves, Gabriel Farias Chambela, Mayara da Costa Curvo, Eduardo de Oliveira Vaz Moreira, Aline dos Santos Sá, Renata Almeida de Mendonça-Lima, Leila Cabello, Pedro Hernan Bailly, Sabine Feige, Jean-Jacques Araujo-Jorge, Tania Cremonini Saraiva, Roberto Magalhães Waghabi, Mariana Caldas |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Ferreira, Roberto Rodrigues Madeira, Fabiana da Silva Alves, Gabriel Farias Chambela, Mayara da Costa Curvo, Eduardo de Oliveira Vaz Moreira, Aline dos Santos Sá, Renata Almeida de Mendonça-Lima, Leila Cabello, Pedro Hernan Bailly, Sabine Feige, Jean-Jacques Araujo-Jorge, Tania Cremonini Saraiva, Roberto Magalhães Waghabi, Mariana Caldas |
dc.subject.en.pt_BR.fl_str_mv |
Chagas disease TGF-β Polymorphisms |
topic |
Chagas disease TGF-β Polymorphisms |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-02-05T11:06:07Z |
dc.date.available.fl_str_mv |
2019-02-05T11:06:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FERREIRA, Roberto Rodrigues et al. TGF-β polymorphisms are a risk factor for Chagas disease. Disease Markers, p. 1-10, 18 Feb. 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/31410 |
dc.identifier.issn.pt_BR.fl_str_mv |
0278-0240 |
dc.identifier.doi.none.fl_str_mv |
10.1155/2018/4579198 |
identifier_str_mv |
FERREIRA, Roberto Rodrigues et al. TGF-β polymorphisms are a risk factor for Chagas disease. Disease Markers, p. 1-10, 18 Feb. 2018. 0278-0240 10.1155/2018/4579198 |
url |
https://www.arca.fiocruz.br/handle/icict/31410 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Hindawi |
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Hindawi |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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