TGF-β polymorphisms are a risk factor for Chagas disease

Detalhes bibliográficos
Autor(a) principal: Ferreira, Roberto Rodrigues
Data de Publicação: 2018
Outros Autores: Madeira, Fabiana da Silva, Alves, Gabriel Farias, Chambela, Mayara da Costa, Curvo, Eduardo de Oliveira Vaz, Moreira, Aline dos Santos, Sá, Renata Almeida de, Mendonça-Lima, Leila, Cabello, Pedro Hernan, Bailly, Sabine, Feige, Jean-Jacques, Araujo-Jorge, Tania Cremonini, Saraiva, Roberto Magalhães, Waghabi, Mariana Caldas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31410
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.
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spelling Ferreira, Roberto RodriguesMadeira, Fabiana da SilvaAlves, Gabriel FariasChambela, Mayara da CostaCurvo, Eduardo de Oliveira VazMoreira, Aline dos SantosSá, Renata Almeida deMendonça-Lima, LeilaCabello, Pedro HernanBailly, SabineFeige, Jean-JacquesAraujo-Jorge, Tania CremoniniSaraiva, Roberto MagalhãesWaghabi, Mariana Caldas2019-02-05T11:06:07Z2019-02-05T11:06:07Z2018FERREIRA, Roberto Rodrigues et al. TGF-β polymorphisms are a risk factor for Chagas disease. Disease Markers, p. 1-10, 18 Feb. 2018.0278-0240https://www.arca.fiocruz.br/handle/icict/3141010.1155/2018/4579198engHindawiTGF-β polymorphisms are a risk factor for Chagas diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil / Universidade do Grande Rio. Laboratório de Genética. Duque de Caxias, RJ, Brasil.INSERM. Grenoble, France / University Grenoble-Alpes. Grenoble, France / CEA, BIG-Biologie du Cancer et de l’Infection. Grenoble, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Transforming growth factor β1 (TGF-β1) is an important mediator in Chagas disease. Furthermore, patients with higher TGF-β1 serum levels show a worse clinical outcome. Gene polymorphism may account for differences in cytokine production during infectious diseases. We tested whether TGFB1 polymorphisms could be associated with Chagas disease susceptibility and severity in a Brazilian population. We investigated five single-nucleotide polymorphisms (-800 G>A, -509 C>T, +10 T>C, +25 G>C, and +263 C>T). 152 patients with Chagas disease (53 with the indeterminate form and 99 with the cardiac form) and 48 noninfected subjects were included. Genotypes CT and TT at position -509 of the TGFB1 gene were more frequent in Chagas disease patients than in noninfected subjects. Genotypes TC and CC at codon +10 of the TGFB1 gene were also more frequent in Chagas disease patients than in noninfected subjects. We found no significant differences in the distribution of the studied TGFB1 polymorphisms between patients with the indeterminate or cardiac form of Chagas disease. Therefore, -509 C>T and +10 T>C TGFB1 polymorphisms are associated with Chagas disease susceptibility in a Brazilian population.Chagas diseaseTGF-β Polymorphismsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Ferreira_Roberto_etal_INI_2018.pdfve_Ferreira_Roberto_etal_INI_2018.pdfapplication/pdf1155807https://www.arca.fiocruz.br/bitstream/icict/31410/2/ve_Ferreira_Roberto_etal_INI_2018.pdf49a7a4dfd6230f5bf50923c8cd975dddMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31410/3/license.txt5a560609d32a3863062d77ff32785d58MD53TEXTve_Ferreira_Roberto_etal_INI_2018.pdf.txtve_Ferreira_Roberto_etal_INI_2018.pdf.txtExtracted texttext/plain42764https://www.arca.fiocruz.br/bitstream/icict/31410/4/ve_Ferreira_Roberto_etal_INI_2018.pdf.txtf573ae01069f9ace4b4895506a77286eMD54icict/314102019-02-17 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dc.title.pt_BR.fl_str_mv TGF-β polymorphisms are a risk factor for Chagas disease
title TGF-β polymorphisms are a risk factor for Chagas disease
spellingShingle TGF-β polymorphisms are a risk factor for Chagas disease
Ferreira, Roberto Rodrigues
Chagas disease
TGF-β Polymorphisms
title_short TGF-β polymorphisms are a risk factor for Chagas disease
title_full TGF-β polymorphisms are a risk factor for Chagas disease
title_fullStr TGF-β polymorphisms are a risk factor for Chagas disease
title_full_unstemmed TGF-β polymorphisms are a risk factor for Chagas disease
title_sort TGF-β polymorphisms are a risk factor for Chagas disease
author Ferreira, Roberto Rodrigues
author_facet Ferreira, Roberto Rodrigues
Madeira, Fabiana da Silva
Alves, Gabriel Farias
Chambela, Mayara da Costa
Curvo, Eduardo de Oliveira Vaz
Moreira, Aline dos Santos
Sá, Renata Almeida de
Mendonça-Lima, Leila
Cabello, Pedro Hernan
Bailly, Sabine
Feige, Jean-Jacques
Araujo-Jorge, Tania Cremonini
Saraiva, Roberto Magalhães
Waghabi, Mariana Caldas
author_role author
author2 Madeira, Fabiana da Silva
Alves, Gabriel Farias
Chambela, Mayara da Costa
Curvo, Eduardo de Oliveira Vaz
Moreira, Aline dos Santos
Sá, Renata Almeida de
Mendonça-Lima, Leila
Cabello, Pedro Hernan
Bailly, Sabine
Feige, Jean-Jacques
Araujo-Jorge, Tania Cremonini
Saraiva, Roberto Magalhães
Waghabi, Mariana Caldas
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Roberto Rodrigues
Madeira, Fabiana da Silva
Alves, Gabriel Farias
Chambela, Mayara da Costa
Curvo, Eduardo de Oliveira Vaz
Moreira, Aline dos Santos
Sá, Renata Almeida de
Mendonça-Lima, Leila
Cabello, Pedro Hernan
Bailly, Sabine
Feige, Jean-Jacques
Araujo-Jorge, Tania Cremonini
Saraiva, Roberto Magalhães
Waghabi, Mariana Caldas
dc.subject.en.pt_BR.fl_str_mv Chagas disease
TGF-β Polymorphisms
topic Chagas disease
TGF-β Polymorphisms
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-02-05T11:06:07Z
dc.date.available.fl_str_mv 2019-02-05T11:06:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv FERREIRA, Roberto Rodrigues et al. TGF-β polymorphisms are a risk factor for Chagas disease. Disease Markers, p. 1-10, 18 Feb. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31410
dc.identifier.issn.pt_BR.fl_str_mv 0278-0240
dc.identifier.doi.none.fl_str_mv 10.1155/2018/4579198
identifier_str_mv FERREIRA, Roberto Rodrigues et al. TGF-β polymorphisms are a risk factor for Chagas disease. Disease Markers, p. 1-10, 18 Feb. 2018.
0278-0240
10.1155/2018/4579198
url https://www.arca.fiocruz.br/handle/icict/31410
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
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instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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