Amblyomma sculptum Salivary PGE2 Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36211 |
Resumo: | Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. São Paulo, SP, Brasil. |
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Esteves, ElianeBizzarro, BrunaCosta, Francisco BorgesRamírez-Hernández, AlejandroPeti, Ana Paula FerrantiCataneo, Allan Henrique DepieriWowk, Pryscilla FaniniTimóteo, Rodolfo PessatoLabruna, Marcelo BahiaSilva Junior, Pedro IsmaelSilva, Célio LopesFaccioli, Lúcia HelenaFogaça, Andréa CristinaSorgi, Carlos ArterioSá-Nunes, Anderson2019-10-04T20:02:50Z2019-10-04T20:02:50Z2019ESTEVES, Eliane et al. Amblyomma sculptum Salivary PGE2 Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo. Frontiers in Immunology, v. 10, n. 118, p. 1-15, 2019.1664-3224https://www.arca.fiocruz.br/handle/icict/3621110.3389/fimmu.2019.001181664-3224engFrontiers MediaCarrapato EstrelaSalivaPGE2ImunomodulaçãoAmblyomma sculptumTicksDinoprostoneDendritic CellsImmunomodulationGarrapatasInmunomodulaciónCarrapatosDinoprostonaCélulas DendríticasRickettsia rickettsiiAmblyomma sculptum Salivary PGE2 Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Ribeirão Preto, SP, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. São Paulo, SP, Brasil.Instituto Buntantan. Laboratório Especial de Toxinologia Aplicada. São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. São Paulo, SP, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Rio de Janeiro, RJ, Brasil.Amblyomma sculptum is an important vector of Rickettsia rickettsii, causative agent of Rocky Mountain spotted fever and the most lethal tick-borne pathogen affecting humans. To feed on the vertebrate host's blood, A. sculptum secretes a salivary mixture, which may interact with skin resident dendritic cells (DCs) and modulate their function. The present work was aimed at depicting the A. sculptum saliva-host DC network and the biochemical nature of the immunomodulatory component(s) involved in this interface. A. sculptum saliva inhibits the production of inflammatory cytokines by murine DCs stimulated with LPS. The fractionation of the low molecular weight salivary content by reversed-phase chromatography revealed active fractions eluting from 49 to 55% of the acetonitrile gradient. Previous studies suggested that this pattern of elution matches with that observed for prostaglandin E2 (PGE2) and the molecular identity of this lipid mediator was unambiguously confirmed by a new high-resolution mass spectrometry methodology. A productive infection of murine DCs by R. rickettsii was demonstrated for the first time leading to proinflammatory cytokine production that was inhibited by both A. sculptum saliva and PGE2, a result also achieved with human DCs. The adoptive transfer of murine DCs incubated with R. rickettsii followed by treatment with A. sculptum saliva or PGE2 did not change the cytokine profile associated to cellular recall responses while IgG2a-specific antibodies were decreased in the serum of these mice. Together, these findings emphasize the role of PGE2 as a universal immunomodulator of tick saliva. In addition, it contributes to new approaches to explore R. rickettsii-DC interactions both in vitro and in vivo.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/36211/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALfimmu-10-0010.pdffimmu-10-0010.pdfapplication/pdf2728904https://www.arca.fiocruz.br/bitstream/icict/36211/2/fimmu-10-0010.pdf9b6bfa3ff965cb333bc997c834cfb154MD52TEXTfimmu-10-0010.pdf.txtfimmu-10-0010.pdf.txtExtracted texttext/plain76537https://www.arca.fiocruz.br/bitstream/icict/36211/3/fimmu-10-0010.pdf.txt4dfd4f26b15a34f32c257791edfaba0dMD53icict/362112019-11-09 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dc.title.pt_BR.fl_str_mv |
Amblyomma sculptum Salivary PGE2 Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo |
title |
Amblyomma sculptum Salivary PGE2 Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo |
spellingShingle |
Amblyomma sculptum Salivary PGE2 Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo Esteves, Eliane Carrapato Estrela Saliva PGE2 Imunomodulação Amblyomma sculptum Ticks Dinoprostone Dendritic Cells Immunomodulation Garrapatas Inmunomodulación Carrapatos Dinoprostona Células Dendríticas Rickettsia rickettsii |
title_short |
Amblyomma sculptum Salivary PGE2 Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo |
title_full |
Amblyomma sculptum Salivary PGE2 Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo |
title_fullStr |
Amblyomma sculptum Salivary PGE2 Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo |
title_full_unstemmed |
Amblyomma sculptum Salivary PGE2 Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo |
title_sort |
Amblyomma sculptum Salivary PGE2 Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo |
author |
Esteves, Eliane |
author_facet |
Esteves, Eliane Bizzarro, Bruna Costa, Francisco Borges Ramírez-Hernández, Alejandro Peti, Ana Paula Ferranti Cataneo, Allan Henrique Depieri Wowk, Pryscilla Fanini Timóteo, Rodolfo Pessato Labruna, Marcelo Bahia Silva Junior, Pedro Ismael Silva, Célio Lopes Faccioli, Lúcia Helena Fogaça, Andréa Cristina Sorgi, Carlos Arterio Sá-Nunes, Anderson |
author_role |
author |
author2 |
Bizzarro, Bruna Costa, Francisco Borges Ramírez-Hernández, Alejandro Peti, Ana Paula Ferranti Cataneo, Allan Henrique Depieri Wowk, Pryscilla Fanini Timóteo, Rodolfo Pessato Labruna, Marcelo Bahia Silva Junior, Pedro Ismael Silva, Célio Lopes Faccioli, Lúcia Helena Fogaça, Andréa Cristina Sorgi, Carlos Arterio Sá-Nunes, Anderson |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Esteves, Eliane Bizzarro, Bruna Costa, Francisco Borges Ramírez-Hernández, Alejandro Peti, Ana Paula Ferranti Cataneo, Allan Henrique Depieri Wowk, Pryscilla Fanini Timóteo, Rodolfo Pessato Labruna, Marcelo Bahia Silva Junior, Pedro Ismael Silva, Célio Lopes Faccioli, Lúcia Helena Fogaça, Andréa Cristina Sorgi, Carlos Arterio Sá-Nunes, Anderson |
dc.subject.other.pt_BR.fl_str_mv |
Carrapato Estrela Saliva PGE2 Imunomodulação |
topic |
Carrapato Estrela Saliva PGE2 Imunomodulação Amblyomma sculptum Ticks Dinoprostone Dendritic Cells Immunomodulation Garrapatas Inmunomodulación Carrapatos Dinoprostona Células Dendríticas Rickettsia rickettsii |
dc.subject.en.pt_BR.fl_str_mv |
Amblyomma sculptum Ticks Dinoprostone Dendritic Cells Immunomodulation |
dc.subject.es.pt_BR.fl_str_mv |
Garrapatas Inmunomodulación |
dc.subject.decs.pt_BR.fl_str_mv |
Carrapatos Dinoprostona Células Dendríticas Rickettsia rickettsii |
description |
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. São Paulo, SP, Brasil. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-10-04T20:02:50Z |
dc.date.available.fl_str_mv |
2019-10-04T20:02:50Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ESTEVES, Eliane et al. Amblyomma sculptum Salivary PGE2 Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo. Frontiers in Immunology, v. 10, n. 118, p. 1-15, 2019. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/36211 |
dc.identifier.issn.pt_BR.fl_str_mv |
1664-3224 |
dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2019.00118 |
dc.identifier.eissn.none.fl_str_mv |
1664-3224 |
identifier_str_mv |
ESTEVES, Eliane et al. Amblyomma sculptum Salivary PGE2 Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo. Frontiers in Immunology, v. 10, n. 118, p. 1-15, 2019. 1664-3224 10.3389/fimmu.2019.00118 |
url |
https://www.arca.fiocruz.br/handle/icict/36211 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Frontiers Media |
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Frontiers Media |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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