Can P-glycoprotein and β-tubulin polymorphisms be used as genetic markers of resistance in Dirofilaria immitis from Rio de Janeiro, Brazil?

Detalhes bibliográficos
Autor(a) principal: Willi, Liliane Maria Valentim
Data de Publicação: 2018
Outros Autores: Labarthe, Norma Vollmer, d'Escoffier, Luiz Ney, Paiva, Jonimar Pereira, Miranda, Marcia Gonçalves Nobre de, Almeida, Flavya Mendes de, Valle, Tânia Zaverucha do
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28478
Resumo: Universidade Federal Fluminense. Faculdade de Veterinária. Programa de Pós‑Graduação em Medicina Veterinária – Clínica e Reprodução Animal. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.
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spelling Willi, Liliane Maria ValentimLabarthe, Norma Vollmerd'Escoffier, Luiz NeyPaiva, Jonimar PereiraMiranda, Marcia Gonçalves Nobre deAlmeida, Flavya Mendes deValle, Tânia Zaverucha do2018-08-30T17:12:22Z2018-08-30T17:12:22Z2018WILLI, Liliane Maria Valentim; et al. Can P-glycoprotein and β-tubulin polymorphisms be used as genetic markers of resistance in Diroflaria immitis from Rio de Janeiro, Brazil?. BMC Resarch Notes, v.11:152, 5p, 2018.1756-0500https://www.arca.fiocruz.br/handle/icict/2847810.1186/s13104-018-3259-zengBioMed CentralMarcador genético de resistênciaDiroflaria immitisLactonas macrocíclicasdirofilariose caninainfecçãoDiroflaria immitisMacrocyclic lactonesGenetic marker of resistanceCan P-glycoprotein and β-tubulin polymorphisms be used as genetic markers of resistance in Dirofilaria immitis from Rio de Janeiro, Brazil?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Faculdade de Veterinária. Programa de Pós‑Graduação em Medicina Veterinária – Clínica e Reprodução Animal. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Veterinária. Programa de Pós‑Graduação em Medicina Veterinária – Clínica e Reprodução Animal. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Departamento de Medicina e Cirurgia Veterinária. Seropédica, RJ, Brasil.Médica Veterinária, Vet Ypiranga. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Veterinária. Programa de Pós‑Graduação em Medicina Veterinária – Clínica e Reprodução Animal. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Veterinária. Programa de Pós‑Graduação em Medicina Veterinária – Clínica e Reprodução Animal. Niterói, RJ, BrasilDirofilaria immitis, the causative agent of , is worldwide the most important filarid to affect domestic dogs. Prevention of this infection is done by macrocyclic lactones, but some reports on the lack of efficacy have been published. Although the actual cause of resistance is unknown, single nucleotide polymorphisms (SNPs) on a P-glycoprotein ABC transporter and β-tubulin genes have been pointed out as candidates for genetic markers of resistance. We conducted a survey to verify the presence of these suggested genetic markers in microfilariae from 30 naturally infected dogs under macrocyclic lactones treatment living in an endemic area in the state of Rio de Janeiro.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28478/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALnorma_LABARTHE_ETAL_ioc_2018.PDFnorma_LABARTHE_ETAL_ioc_2018.PDFapplication/pdf1026902https://www.arca.fiocruz.br/bitstream/icict/28478/2/norma_LABARTHE_ETAL_ioc_2018.PDF557a4e9a1ac3873af86f4f7889b1112dMD52TEXTnorma_LABARTHE_ETAL_ioc_2018.PDF.txtnorma_LABARTHE_ETAL_ioc_2018.PDF.txtExtracted texttext/plain23578https://www.arca.fiocruz.br/bitstream/icict/28478/3/norma_LABARTHE_ETAL_ioc_2018.PDF.txt5745e0b6d2d0c6e5bed2a2ef24d32473MD53icict/284782018-08-31 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dc.title.pt_BR.fl_str_mv Can P-glycoprotein and β-tubulin polymorphisms be used as genetic markers of resistance in Dirofilaria immitis from Rio de Janeiro, Brazil?
title Can P-glycoprotein and β-tubulin polymorphisms be used as genetic markers of resistance in Dirofilaria immitis from Rio de Janeiro, Brazil?
spellingShingle Can P-glycoprotein and β-tubulin polymorphisms be used as genetic markers of resistance in Dirofilaria immitis from Rio de Janeiro, Brazil?
Willi, Liliane Maria Valentim
Marcador genético de resistência
Diroflaria immitis
Lactonas macrocíclicas
dirofilariose canina
infecção
Diroflaria immitis
Macrocyclic lactones
Genetic marker of resistance
title_short Can P-glycoprotein and β-tubulin polymorphisms be used as genetic markers of resistance in Dirofilaria immitis from Rio de Janeiro, Brazil?
title_full Can P-glycoprotein and β-tubulin polymorphisms be used as genetic markers of resistance in Dirofilaria immitis from Rio de Janeiro, Brazil?
title_fullStr Can P-glycoprotein and β-tubulin polymorphisms be used as genetic markers of resistance in Dirofilaria immitis from Rio de Janeiro, Brazil?
title_full_unstemmed Can P-glycoprotein and β-tubulin polymorphisms be used as genetic markers of resistance in Dirofilaria immitis from Rio de Janeiro, Brazil?
title_sort Can P-glycoprotein and β-tubulin polymorphisms be used as genetic markers of resistance in Dirofilaria immitis from Rio de Janeiro, Brazil?
author Willi, Liliane Maria Valentim
author_facet Willi, Liliane Maria Valentim
Labarthe, Norma Vollmer
d'Escoffier, Luiz Ney
Paiva, Jonimar Pereira
Miranda, Marcia Gonçalves Nobre de
Almeida, Flavya Mendes de
Valle, Tânia Zaverucha do
author_role author
author2 Labarthe, Norma Vollmer
d'Escoffier, Luiz Ney
Paiva, Jonimar Pereira
Miranda, Marcia Gonçalves Nobre de
Almeida, Flavya Mendes de
Valle, Tânia Zaverucha do
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Willi, Liliane Maria Valentim
Labarthe, Norma Vollmer
d'Escoffier, Luiz Ney
Paiva, Jonimar Pereira
Miranda, Marcia Gonçalves Nobre de
Almeida, Flavya Mendes de
Valle, Tânia Zaverucha do
dc.subject.other.pt_BR.fl_str_mv Marcador genético de resistência
Diroflaria immitis
Lactonas macrocíclicas
dirofilariose canina
infecção
topic Marcador genético de resistência
Diroflaria immitis
Lactonas macrocíclicas
dirofilariose canina
infecção
Diroflaria immitis
Macrocyclic lactones
Genetic marker of resistance
dc.subject.en.pt_BR.fl_str_mv Diroflaria immitis
Macrocyclic lactones
Genetic marker of resistance
description Universidade Federal Fluminense. Faculdade de Veterinária. Programa de Pós‑Graduação em Medicina Veterinária – Clínica e Reprodução Animal. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-08-30T17:12:22Z
dc.date.available.fl_str_mv 2018-08-30T17:12:22Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv WILLI, Liliane Maria Valentim; et al. Can P-glycoprotein and β-tubulin polymorphisms be used as genetic markers of resistance in Diroflaria immitis from Rio de Janeiro, Brazil?. BMC Resarch Notes, v.11:152, 5p, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28478
dc.identifier.issn.pt_BR.fl_str_mv 1756-0500
dc.identifier.eissn.none.fl_str_mv 10.1186/s13104-018-3259-z
identifier_str_mv WILLI, Liliane Maria Valentim; et al. Can P-glycoprotein and β-tubulin polymorphisms be used as genetic markers of resistance in Diroflaria immitis from Rio de Janeiro, Brazil?. BMC Resarch Notes, v.11:152, 5p, 2018.
1756-0500
10.1186/s13104-018-3259-z
url https://www.arca.fiocruz.br/handle/icict/28478
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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