Preparation of pellets containing a standardized Artemisia annua L. extract by extrusionspheronization

Detalhes bibliográficos
Autor(a) principal: Silva, Elviscley de Oliveira
Data de Publicação: 2021
Outros Autores: Marreto, Ricardo Neves, Conceição, Edemilson Cardoso da, Bara, Maria Teresa Freitas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48191
Resumo: Universidade Federal de Goiás. Faculdade de Farmácia. Goiânia, GO, Brasil.
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spelling Silva, Elviscley de OliveiraMarreto, Ricardo NevesConceição, Edemilson Cardoso daBara, Maria Teresa Freitas2021-07-12T20:22:03Z2021-07-12T20:22:03Z2021SILVA, Elviscley de Oliveira et al. Preparation of pellets containing a standardized Artemisia annua L. extract by extrusionspheronization. Revista Fitos, v. 15, n. 1, p. 84-92, Mar. 2021.1808-9569https://www.arca.fiocruz.br/handle/icict/4819110.32712/2446-4775.2021.10632446-4775engFundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e SaúdePreparation of pellets containing a standardized Artemisia annua L. extract by extrusionspheronizationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Goiás. Faculdade de Farmácia. Goiânia, GO, Brasil.Universidade Federal de Goiás. Faculdade de Farmácia. Goiânia, GO, Brasil.Universidade Federal de Goiás. Faculdade de Farmácia. Goiânia, GO, Brasil.Universidade Federal de Goiás. Faculdade de Farmácia. Goiânia, GO, Brasil.Artemisinin, the major substance with antimalarial activity of Artemisia annua L., is a poorly water-soluble drug. The development of pellets containing a standardized hydroethanolic extract of A. annua may overcome these drawbacks while offer an intermediate product with good technological properties for subsequent tablet manufacture. This work aimed to obtain and characterize A. annua pellets using the extrusion-spheronization technique. The extract was prepared by percolation and artemisinin content was determined using a validated HPLC method. The standardized extract was then used as a liquid binder in the preparation of pellets with different liquid: solid ratio. The formulation PF5 containing microcrystalline cellulose: A. annua extract (40:58) resulted in pellets with 1.49 ± 0.02 % (w/w) artemisinin, average size of approximately 500 µm and sphericity of 0.82 ± 0.08. These pellets were encapsulated in hard gelatin capsules and the percentage released was higher than 80% in 10 min using 0.1N HCl and phosphate buffer media. These data allow to suggest that the pelletizing strategy used made it possible to achieve the desired artemisinin dissolution and generates perspectives for the potential further use of the A. annua pellets as a solid dosage form for malaria treatment.Herbal medicinalArtemisininMultiparticulate solid dosage formPhytopharmaceutical technologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/48191/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALe_d_o_et_all.pdfapplication/pdf313799https://www.arca.fiocruz.br/bitstream/icict/48191/2/e_d_o_et_all.pdf92624a62d17bbb45943518e1b6c17095MD52TEXTe_d_o_et_all.pdf.txte_d_o_et_all.pdf.txtExtracted texttext/plain29729https://www.arca.fiocruz.br/bitstream/icict/48191/3/e_d_o_et_all.pdf.txt7150a9ad465d94f010127e98e712aa15MD53icict/481912022-12-08 13:36:11.146oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-12-08T16:36:11Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Preparation of pellets containing a standardized Artemisia annua L. extract by extrusionspheronization
title Preparation of pellets containing a standardized Artemisia annua L. extract by extrusionspheronization
spellingShingle Preparation of pellets containing a standardized Artemisia annua L. extract by extrusionspheronization
Silva, Elviscley de Oliveira
Herbal medicinal
Artemisinin
Multiparticulate solid dosage form
Phytopharmaceutical technology
title_short Preparation of pellets containing a standardized Artemisia annua L. extract by extrusionspheronization
title_full Preparation of pellets containing a standardized Artemisia annua L. extract by extrusionspheronization
title_fullStr Preparation of pellets containing a standardized Artemisia annua L. extract by extrusionspheronization
title_full_unstemmed Preparation of pellets containing a standardized Artemisia annua L. extract by extrusionspheronization
title_sort Preparation of pellets containing a standardized Artemisia annua L. extract by extrusionspheronization
author Silva, Elviscley de Oliveira
author_facet Silva, Elviscley de Oliveira
Marreto, Ricardo Neves
Conceição, Edemilson Cardoso da
Bara, Maria Teresa Freitas
author_role author
author2 Marreto, Ricardo Neves
Conceição, Edemilson Cardoso da
Bara, Maria Teresa Freitas
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva, Elviscley de Oliveira
Marreto, Ricardo Neves
Conceição, Edemilson Cardoso da
Bara, Maria Teresa Freitas
dc.subject.en.en_US.fl_str_mv Herbal medicinal
Artemisinin
Multiparticulate solid dosage form
Phytopharmaceutical technology
topic Herbal medicinal
Artemisinin
Multiparticulate solid dosage form
Phytopharmaceutical technology
description Universidade Federal de Goiás. Faculdade de Farmácia. Goiânia, GO, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-07-12T20:22:03Z
dc.date.available.fl_str_mv 2021-07-12T20:22:03Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Elviscley de Oliveira et al. Preparation of pellets containing a standardized Artemisia annua L. extract by extrusionspheronization. Revista Fitos, v. 15, n. 1, p. 84-92, Mar. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48191
dc.identifier.issn.none.fl_str_mv 1808-9569
dc.identifier.doi.none.fl_str_mv 10.32712/2446-4775.2021.1063
dc.identifier.eissn.none.fl_str_mv 2446-4775
identifier_str_mv SILVA, Elviscley de Oliveira et al. Preparation of pellets containing a standardized Artemisia annua L. extract by extrusionspheronization. Revista Fitos, v. 15, n. 1, p. 84-92, Mar. 2021.
1808-9569
10.32712/2446-4775.2021.1063
2446-4775
url https://www.arca.fiocruz.br/handle/icict/48191
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e Saúde
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e Saúde
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/48191/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/48191/2/e_d_o_et_all.pdf
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