Polymorphisms in TLR4 and TNFA and Risk of Mycobacterium tuberculosis Infection and Development of Active Disease in Contacts of Tuberculosis Cases in Brazil: A Prospective Cohort Study

Detalhes bibliográficos
Autor(a) principal: Cubillos-Angulo, Juan Manuel
Data de Publicação: 2018
Outros Autores: Arriaga Gutiérrez, María Belen, Silva, Elisangela Costa da, Müller, Beatriz de Lima Alessio, Ramalho, Daniela Maria de Paula, Fukutani, Kiyoshi Ferreira, Miranda, Pryscila Fernandes Campino, Moreira, Adriana S. R., Ruffino Netto, Antonio, Silva, Jose Roberto Lapa e, Sterling, Timothy R., Kritski, Afrânio Lineu, Oliveira, Martha Maria de, Andrade, Bruno de Bezerril
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30717
Resumo: This work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / Instituto Nacional de Ciência e Tecnologia (INCT, grant number: 573548/2008-0) and Fundação de Amparo à Pesquisa do Rio de Janeiro (FAPERJ, grant number: E-26/110.974/2011). AK is the recipient of a career award from CNPq (produtividade em pesquisa) and FAPERJ (Cientistas do Nosso Estado). The work from BBA and KFF was supported by intramural research program from FIOCRUZ and from the National Institutes of Health (U01AI115940). JMC-A was supported by the Organization of American States - Partnerships Program for Education and Training (OAS-PAEC). MBA receives a fellowship from the Fundação de Amparo à Pesquisa da Bahia (FAPESB).
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spelling Cubillos-Angulo, Juan ManuelArriaga Gutiérrez, María BelenSilva, Elisangela Costa daMüller, Beatriz de Lima AlessioRamalho, Daniela Maria de PaulaFukutani, Kiyoshi FerreiraMiranda, Pryscila Fernandes CampinoMoreira, Adriana S. R.Ruffino Netto, AntonioSilva, Jose Roberto Lapa eSterling, Timothy R.Kritski, Afrânio LineuOliveira, Martha Maria deAndrade, Bruno de Bezerril2018-12-20T13:12:03Z2018-12-20T13:12:03Z2018CUBILLOS-ANGULO, J. M. et al. Polymorphisms in TLR4 and TNFA and risk of mycobacterium tuberculosis infection and development of active disease in contacts of tuberculosis cases in Brazil: A prospective cohort study. Clinical Infectious Disease, p. 1-35, Nov. 2018.https://www.arca.fiocruz.br/handle/icict/3071710.1093/cid/ciy1001This work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / Instituto Nacional de Ciência e Tecnologia (INCT, grant number: 573548/2008-0) and Fundação de Amparo à Pesquisa do Rio de Janeiro (FAPERJ, grant number: E-26/110.974/2011). AK is the recipient of a career award from CNPq (produtividade em pesquisa) and FAPERJ (Cientistas do Nosso Estado). The work from BBA and KFF was supported by intramural research program from FIOCRUZ and from the National Institutes of Health (U01AI115940). JMC-A was supported by the Organization of American States - Partnerships Program for Education and Training (OAS-PAEC). MBA receives a fellowship from the Fundação de Amparo à Pesquisa da Bahia (FAPESB).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil / State University of North Fluminense Darcy Ribeiro. Recognize the Biology Laboratory. Center of Bioscience and Biotechnology. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Osvaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, BrazilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil.Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, Tennessee, USA.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, Tennessee, USA / University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Wellcome Centre for Infectious Disease Research in Africa. Cape Town, South Africa / Universidade Salvador. Laureate University. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Background: The role of genetic polymorphisms in latent tuberculosis (TB) infection and progression to active TB is not fully understood. Methods: We tested the single nucleotide polymorphisms (SNPs) rs5743708 (TLR2), rs4986791 (TLR4), rs361525 (TNFA), rs2430561 (IFNG) rs1143627 (IL1B) as risk factors for tuberculin skin test (TST) conversion or development of active TB in contacts of active TB cases. Contacts of microbiologically confirmed pulmonary TB cases were initially screened for longitudinal evaluation up to 24 months, with clinical examination and serial TST, between 1998 and 2004 at a referral center in Brazil. Data and biospecimens were collected from 526 individuals who were contacts of 177 active TB index cases. TST conversion was defined as ≥5 f TST result (0 mm) at baseline or month 4 visit. Independent associations were tested using logistic regression models.engOxfor University PressPolymorphisms in TLR4 and TNFA and Risk of Mycobacterium tuberculosis Infection and Development of Active Disease in Contacts of Tuberculosis Cases in Brazil: A Prospective Cohort Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSingle nucleotide polymorphismTuberculin skin testMycobacterium tuberculosisTumor necrosis factorToll-like receptorNãoNão Publicadoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30717/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCubillos Angulo. J. Polymorphisms in TLR4 and TNFA...2018.pdfCubillos Angulo. J. 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dc.title.pt_BR.fl_str_mv Polymorphisms in TLR4 and TNFA and Risk of Mycobacterium tuberculosis Infection and Development of Active Disease in Contacts of Tuberculosis Cases in Brazil: A Prospective Cohort Study
title Polymorphisms in TLR4 and TNFA and Risk of Mycobacterium tuberculosis Infection and Development of Active Disease in Contacts of Tuberculosis Cases in Brazil: A Prospective Cohort Study
spellingShingle Polymorphisms in TLR4 and TNFA and Risk of Mycobacterium tuberculosis Infection and Development of Active Disease in Contacts of Tuberculosis Cases in Brazil: A Prospective Cohort Study
Cubillos-Angulo, Juan Manuel
Single nucleotide polymorphism
Tuberculin skin test
Mycobacterium tuberculosis
Tumor necrosis factor
Toll-like receptor
title_short Polymorphisms in TLR4 and TNFA and Risk of Mycobacterium tuberculosis Infection and Development of Active Disease in Contacts of Tuberculosis Cases in Brazil: A Prospective Cohort Study
title_full Polymorphisms in TLR4 and TNFA and Risk of Mycobacterium tuberculosis Infection and Development of Active Disease in Contacts of Tuberculosis Cases in Brazil: A Prospective Cohort Study
title_fullStr Polymorphisms in TLR4 and TNFA and Risk of Mycobacterium tuberculosis Infection and Development of Active Disease in Contacts of Tuberculosis Cases in Brazil: A Prospective Cohort Study
title_full_unstemmed Polymorphisms in TLR4 and TNFA and Risk of Mycobacterium tuberculosis Infection and Development of Active Disease in Contacts of Tuberculosis Cases in Brazil: A Prospective Cohort Study
title_sort Polymorphisms in TLR4 and TNFA and Risk of Mycobacterium tuberculosis Infection and Development of Active Disease in Contacts of Tuberculosis Cases in Brazil: A Prospective Cohort Study
author Cubillos-Angulo, Juan Manuel
author_facet Cubillos-Angulo, Juan Manuel
Arriaga Gutiérrez, María Belen
Silva, Elisangela Costa da
Müller, Beatriz de Lima Alessio
Ramalho, Daniela Maria de Paula
Fukutani, Kiyoshi Ferreira
Miranda, Pryscila Fernandes Campino
Moreira, Adriana S. R.
Ruffino Netto, Antonio
Silva, Jose Roberto Lapa e
Sterling, Timothy R.
Kritski, Afrânio Lineu
Oliveira, Martha Maria de
Andrade, Bruno de Bezerril
author_role author
author2 Arriaga Gutiérrez, María Belen
Silva, Elisangela Costa da
Müller, Beatriz de Lima Alessio
Ramalho, Daniela Maria de Paula
Fukutani, Kiyoshi Ferreira
Miranda, Pryscila Fernandes Campino
Moreira, Adriana S. R.
Ruffino Netto, Antonio
Silva, Jose Roberto Lapa e
Sterling, Timothy R.
Kritski, Afrânio Lineu
Oliveira, Martha Maria de
Andrade, Bruno de Bezerril
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cubillos-Angulo, Juan Manuel
Arriaga Gutiérrez, María Belen
Silva, Elisangela Costa da
Müller, Beatriz de Lima Alessio
Ramalho, Daniela Maria de Paula
Fukutani, Kiyoshi Ferreira
Miranda, Pryscila Fernandes Campino
Moreira, Adriana S. R.
Ruffino Netto, Antonio
Silva, Jose Roberto Lapa e
Sterling, Timothy R.
Kritski, Afrânio Lineu
Oliveira, Martha Maria de
Andrade, Bruno de Bezerril
dc.subject.en.pt_BR.fl_str_mv Single nucleotide polymorphism
Tuberculin skin test
Mycobacterium tuberculosis
Tumor necrosis factor
Toll-like receptor
topic Single nucleotide polymorphism
Tuberculin skin test
Mycobacterium tuberculosis
Tumor necrosis factor
Toll-like receptor
description This work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / Instituto Nacional de Ciência e Tecnologia (INCT, grant number: 573548/2008-0) and Fundação de Amparo à Pesquisa do Rio de Janeiro (FAPERJ, grant number: E-26/110.974/2011). AK is the recipient of a career award from CNPq (produtividade em pesquisa) and FAPERJ (Cientistas do Nosso Estado). The work from BBA and KFF was supported by intramural research program from FIOCRUZ and from the National Institutes of Health (U01AI115940). JMC-A was supported by the Organization of American States - Partnerships Program for Education and Training (OAS-PAEC). MBA receives a fellowship from the Fundação de Amparo à Pesquisa da Bahia (FAPESB).
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-12-20T13:12:03Z
dc.date.available.fl_str_mv 2018-12-20T13:12:03Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CUBILLOS-ANGULO, J. M. et al. Polymorphisms in TLR4 and TNFA and risk of mycobacterium tuberculosis infection and development of active disease in contacts of tuberculosis cases in Brazil: A prospective cohort study. Clinical Infectious Disease, p. 1-35, Nov. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30717
10.1093/cid/ciy1001
identifier_str_mv CUBILLOS-ANGULO, J. M. et al. Polymorphisms in TLR4 and TNFA and risk of mycobacterium tuberculosis infection and development of active disease in contacts of tuberculosis cases in Brazil: A prospective cohort study. Clinical Infectious Disease, p. 1-35, Nov. 2018.
10.1093/cid/ciy1001
url https://www.arca.fiocruz.br/handle/icict/30717
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxfor University Press
publisher.none.fl_str_mv Oxfor University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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